Tag: "islets" at medical news
Single-donor islet transplantation procedure shows promise for patients with type 1 diabetes
...eased markedly by transplanting a higher number of islets
prepared from 2 to 4 donor pancreases. However, fo...y. We not only achieved insulin independence using islets
from only 1 donor pancreas [as compared with 2 to 4 in another trial], we also achieved superior gly...
World-first living donor islet cell transplant a success
...as. Dr. Shinichi Masumoto then isolated the living islets
in the Kyoto Centre for Cell and Molecular Therapy...'s 27-year-old diabetic daughter. The transplanted islets
began producing insulin within minutes, explains Dr. Shapiro. "The reason I'm so excited about this ...
Immune cells may play important role in progression of type 1 diabetes, Joslin researchers find
...ocess, white blood cells called T-cells invade the islets
of Langerhans of the pancreas, where the beta cells reside (a condition known as "insulitis"). Yet, in both mice and humans, insulitis does not always progress to full-blown type 1 diabetes. For years, scientists have been trying to determine why in...
Gene therapy technique could aid islet transplants for diabetes, says Pittsburgh study
...nsplants is harmful to transplanted rat pancreatic islets
and can actually induce diabetes in rats. "This st...n and prolongs beta cell survival, into pancreatic islets
that had been extracted from rat pancreases. Having conducted similar previous research on genetical...
Laboratory studies show a natural protein analog may fix insulin-making cells isolated from pancreas
... growth of new islet cells and prevents overworked islets
from dying prematurely. The study, reported in the..." said Dr. Perfetti. In the study, two groups of islets
were isolated from the human pancreas and cultured in the laboratory for five days. One group was t...
JCI Table of Contents, November 14, 2003
...oves islet transplantation, as significantly fewer islets
were required to normalize serum glucose levels. The data support a potential pharmacological role for Irs2 or downstream factors in the treatment of beta cell failure and human diabetes. TITLE: Upregulation of insulin receptor substrate-2 in pancrea...
Regeneration of insulin-producing islets may lead to diabetes cure
...e have found that it is possible to rapidly regrow islets
from adult precursor cells, something that many th...c mice or of regeneration of the insulin-secreting islets
from another source," says Faustman. "We've found that islet regeneration was occurring and that ce...
Russell Berrie Foundation gift to Columbia University propels diabetes treatment into new era
...s are an example of such treatment. However, human islets
are a very limited resource. New means of creating insulin-producing cells are needed. Diabetes research in cellular therapy is directed at engineering cells to produce insulin. Success in these efforts could spare patients the need for daily insuli...
Special cell prevents diabetes in mouse model, report University of Pittsburgh researchers
...d destroy the body's insulin- producing cells, the islets
of Langerhans, which are located in the pancreas. Normally T cells are engaged to attack outside foreign invaders, like a transplanted organ, when antigen-presenting cells, such as dendritic cells, identify and present these foreign substances to the...
JDRF launches multimillion-dollar Center for Islet Transplantation at Emory University
...e facing islet transplantation: rejection of donor islets
by the patients immune system. Although islet tran...n current therapies and also testing whether donor islets
transplanted from animals can be protected in a sheath-like membrane from the bodys immune response....
NIAID spearheads collaborative network for clinical research on immune tolerance
...n, an experimental therapy that replacespancreatic islets
destroyed by type 1 diabetes, have been even less successful. Only about 5 percent of people with diabetes who receive transplanted isletsalong with immunosuppressive drugs are able to stay off insulin longer than oneyear. Recent tests of tolerogenic...
Encapsulating Insulin-Producing Cells For Possible Diabetes Therapy
... can design a system in which we cantransplant the islets
from one species into another species by using our...ne system would normally identify suchtransplanted islets
as "foreign," and thus target them for destruction. The microcapsules being developed in Gri...