Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...emains elevated because the fat cells neverreceive its "slimming" signal. In studying the leptin loop, ...ocess continues, energy burned by brown fat exerts its metabolic effectson white fat -- in essence "burning" stored white fat. In demonstrating noradrenal...AIDS Treatments Seek To Eradicate Virus, Restore Immunity
...ich interrupt a stepin the virus's life cycle when its genetic material is inserted in a hostcell's gene.... year, kills HIV by crippling an enzyme crucial to its survival,a mechanism different from other anti-viral compounds. The three drugs are expected to re...Study Says Machine Sensors Applicable To Human Ills
... to lead the PredictiveDiagnostics Team because of its success in transferring military technologyto civilian applications. ARL, which was 50 years old last year, has madesignificant contributions to fluid mechanics and acoustics that have beenapplied to naval and commercial vehicle propulsion systems, d...New Colorectal Cancer Treatment Available
...amptosar, was cleared on June 14 by the FDA, under its accelerated approval regulations, for use as a sec...re, research, and education in cancer. Throughout its long, distinguished history, the Center has played a leadership role in defining the standard of car...Discovery Hints At Multitude Of New Targets For Drugs
... causethe same receptor to trigger only certain of its normal effects in the body,but not others. The finding, if confirmed, could point the way to a new wave of drugs withfewer side effects for contraception, hormone replacement therapy, breastand prostate cancer, inflammation, osteoporosis and...What Makes Tics Tick? Clues Found In Tourette Twins' Caudates
...ndrome, which affects about 100,000 Americans with its full-blown form and up to 0.5% of the population w...perienced over the course of Tourette Syndrome and its overlap with obsessive compulsive disorder. "While we know that genetics plays an important role in ...Scientists Produce New Anti-Malarial Compound
...cal attracts a hydrogen atom, plucking itaway from its bond with a carbon atom and producing an electron-...nce to chloroquine more thanthree decades ago, and its resistance is spreading progressivelythroughout the world. The disease is spread by a genus of mosqu...A Surgical Semiconductor Laser With More Precision And Power
...lose the ability to focus a semiconductor laser on its target," Marciantesays. "Rather than a single strong beam, you get three to five weaker beams, greatly diminishing the laser's power andperformance." To compensate for this breakdown of semiconductor laser beams -- known as "filamentation" -- Ag...Stents Work Well, But Are Costly: Will Hospitals Continue To Use Them?
...ve been cleared by balloon angioplasty. Because of its effectiveness,stenting has quickly become a popula... $13,000 dependingon the kind of hospital) through its payment system to perform either anangioplasty or an angioplasty that delivers a stent. And managed ...Postmature Infants Not As Easily Calmed As Other Newborns
...ideal to support thefetus, it begins living off of its own body fat. Therefore, the babies are often born with an old-wizenedappearance, compared to normal infants, and the skin is loose,dry and sometimes cracked and bleeding, due to dehydration.Psychologists are uncovering evidence that the extended ges...Johns Hopkins To Announce AIDS Capitated Care Program
...ation, the program will use Hopkins specialistsand its network of sub-specialists to provide all health care to subscribers. The program is a prototype for HIV care that could be adopted nationallyin the next few years, according to John G. Bartlett, director of the divisionof infectious diseases. Hop...ACTG 315 Preliminary Results: Drug Cocktail Restores Partial Immune Function
...toire of T-cells according to a variable region on its receptor,V, which can exist in 24 different varieties in humans. Patientswith dramatic but restricted patterns of V expansion experiencemore rapid progression of HIV disease than other patients. InACTG 315, V repertoires were highly perturbed at ba...Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
..."We hypothesized that a binding site might arrange its atoms suchthat it's especially hydrophobic, much m...ing site.That means it really, really wants to get its water out." Under their hypothesis, "water leaving would make a much largercontribution to lig...Laser Offers Hope For Heart Patients With No Alternatives
...e company recently was granted expedited review of its premarketapproval application for the Heart Laser by the U.S. Food and Drug Administration(FDA). To date, more than 350 patients have undergone the procedure inthe United States. The procedure, known as transmyocardial revascularization (TM...UNC-CH Study Shows State Protects HMO Clients Poorly
...participation mechanisms.” The state earned its top marks for both its oversight of HMO premium rates and its financial solvency requirements, she said. It received “...Substance from Grapefruit Juice May Make Medications Safer
...stance in grapefruit juice that is responsible for its effects on drug metabolism. Isolating this substance could enable manufacturers to produce safer and more effective medications. One of the most interesting findings from the University of Michigan study is that, after taking grapefruit juice, CYP3......data classifier for processingnew mammograms." In its mammogram analysis, the software did not miss anymicrocalcifications in any of the digitized mammograms that wereproperly calibrated. "In all of the data that's similar to our database data, thisapproach achieved nearly 100 percent detection with wh...Study Injects New Interest In How Vaccines Work
... antibodies in response to the antigens carried on its surface." The study raises new questions about the mechanism by which aluminum hydroxide works, Hem says. The findings will appear in the September issue of the British scientific journal Vaccine. During the 1930s, researchers discovered that using a...Milk Extract May Heal Wounds And Smooth Wrinkles
...nd-healing in animals. The extract will soon face its next major test to see if it speeds upthe healing ...cessful, he says, it will be the only substance of its kind in the world. "There's nothing on the market which actually stimulates wound repair,"he says. ......rapy in cancer cells that have become resistant to its effects. Thetechnique temporarily inhibits product...P-glycoprotein isinducible, activated by cues from its environment, investigators were interestedin how it would be affected by cancer chemotherapy drugs. ...