JCI table of contents, January 20 2005
Molecule predicts colon cancer patient survival ... ......Harvard researchers have examined the factors that help spur the progression of colorectal cancer and identified the integrin [alpha]v[beta]6 as an important risk factor for development of early-stage disease. They further demonstrate that detection of high levels of this molecule is able to predict patient survival for colorectal cancer,...... Current treatment for progressed prostate cancer is withdrawal of the hormone androgen. While initially effective, this treatment is unable to completely and permanently eliminate all prostate cancer cells. It is not uncommon, that after a patient shows an initial response to treatment, there is a relapse as the cancer progresses to an androgen-independent stage. A major goal of researchers...JCI Table of Contents, November 14, 2003
... ...Curing human diseases using gene transfer into human hematopoietic stem cells (HSCs) ...remains a promising avenue for development. In the November 14 issue of the Journal of Clinical Investigation, two independent studies the first by Stanton Gerson and colleagues at Case Western University and the second by Hans-Peter Kiem and colleagues at the Fred Hutchinson Cancer Research Center......... Alzhemier disease (AD) is characterized by the progressive accumulation of amyloid beta protein (Abeta) in areas of the brain serving cognitive functions such as memory and language. In 2001, Todd Golde and colleagues demonstrated that three commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) were capable of selectively lowering the levels of Abeta42 (an isoform of the Abeta prote...Find below three highlighted articles and the full Table of Contents for the...issue....... ... ... ...T cells and antibody-producing B cells carry out immune defense against...specific pathogens such as viruses. Antibodies and T cell receptors are...highly diverse molecules that can recognize millions of different molecules....Upon encounter of a foreign antigen (such as a molecule from the surf...