Enzyme linked to mania and schizophrenia impairs higher brain functions
Overactivity of protein kinase C (PKC), an enzyme that is implicated in bipolar disorder and schizophrenia, markedly impairs higher brain functions in animals, according to a Yale study published Oct. 29 in Science . The research adds to mounting evidence that excessive activity ...Gene-silencing technique offers new way to fight drug-resistant leukemia
...roach because they are not so dependent on the Lyn kinase as CML cells. The Lyn kinase is therefore a good candidate for a targeted therapy. "We know that patients treated with Gleevec c...Novel drugs help solve Gleevec resistance
...ions, reduces the activity of an abnormal tyrosine kinase enzyme that leads to uncontrolled cell growth. Bot...g gene, BCR-ABL. This oncogene produces a tyrosine kinase that turns on multiple signals that tell the cells to grow and divide in an uncontrolled manner lead...Breast cancer may be 'uniquely sensitive' to inhibitors of PI3K pathway
...about the importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development, says Gordon Mills, M.D., Ph.D., a professor and chair of the Department of Molecular Therapeutics. This pathway, which is linked to critical growth factor receptors and is involved in programmed cell death...Substance in urine predicts development of preeclampsia
... that a substance called soluble fms-like tyrosine kinase 1 (sFlt-1) circulates in large quantities in the bloodstreams of women with preeclampsia and that sFlt-1 injected into the bloodstream of pregnant rats caused a preeclampsia-like illness. Last year, Drs. Levine, Karumanchi and their coworkers report...Researchers identify the link between heart failure and weight loss
... the signaling pathway known as the Akt/mTOR/p70S6 kinase pathway is involved in this ability of IGF-1 to prevent muscle loss. These findings have broad relevance to the events leading to muscle loss in a variety of conditions such as chronic congestive heart failure and chronic renal failure. In addition, ...Special imaging study shows failing hearts are 'energy starved'
...al that fuels heart contractions and that creatine kinase (CK) is the enzyme for one of the sources of ATP, we believe this is the first time someone has actually measured the flux of ATP produced by CK reaction in the beating human heart." Specifically, Bottomley and a team of cardiologists and radiologist...Study finds new designer drug is potent treatment for chronic myelogenous leukemia
...ing the function of Bcr-Abl, the abnormal tyrosine kinase protein in the leukemic cells that causes them to grow too quickly. However, it does not bind very tightly to this protein, takes a long time to induce remissions, and patients can develop a resistant type of Bcr-Abl that no longer binds to Gleevec a...News tips from the Journal of Neuroscience
.... This week, Qiu et al. provide evidence for Janus kinase (JAK)signal transducer and activator of transcription (STAT) signaling downstream of the cytokines. The JAK2STAT3 pathway appears to be growth-promoting after a peripheral nerve injury....Study finds new designer drug is potent treatment for chronic myelogenous leukemia
...tis Pharma AG, AMN107 is a small molecule tyrosine kinase inhibitor. "While Gleevec represents a major treat...ing the function of Bcr-Abl, the abnormal tyrosine kinase protein in the leukemic cells that causes them to grow too quickly. However, it does not bind very t......roved lung cancer drugs. The drugs are so-called kinase inhibitors and inhibit the epidermal growth factor receptor (EGFR) kinase molecule. Both of them, gefitinib (Iressa) and erlotinib (Tarceva), have shown therapeutic benefits ...LRRK2 gene mutation causes Parkinson's disease in several families
...There are already clinical trials of mixed-lineage kinase inhibitors that may be targeted at this form of the disorder. Our objectives are to understand the molecular events that cause Parkinson's disease and to target therapeutics to halt its progression."...