Tag: "lamivudine" at medical news
No advantage of combination drug therapy for chronic hepatitis B Infection
...th pegylated interferon -2 and the antiviral agent lamivudine
was more efficacious in treating chronic hepatitis B infection than pegylated interferon -2 therapy alone. Around 300 patients from 42 centres in 15 countries who had chronic hepatitis B were assigned combination therapy or monotherapy for one year....
Nevirapine is better than efavirenz at raising 'good' cholesterol
...combination with other drugs such as stavudine and lamivudine
which costs only US$1 per day."...
FDA approves EPZICOM
...proved in 1997, and TRIZIVIR(R) (abacavir sulfate, lamivudine
and zidovudine) was approved in 2000. The medications contained in EPZICOM have been well studied in BID (twice a day) and QD dosing regimens and in multiple combinations with other classes of antiretroviral drugs. Multiple clinical trials have stu...
Weekly cycles of once-daily anti-HIV drugs could reduce cost of HIV treatment
...e-daily treatment with the drugs didanosine (ddI), lamivudine
(3TC) and efavirenz for 7 days, followed by 7 days off the antiretroviral drugs, repeating the off-on cycle for more than a year. One patient withdrew from the study for personal reasons at week 24; the other seven patients receiving the 7-7 regimen ...
Combination, order of anti-HIV drugs make a difference in first-time recipients
...tion of the drugs zidovudine, better known as AZT, lamivudine
and efavirenz, the drugs retain their effectivenes...r groups began treatment with zidovudine (ZDV) and lamivudine
(3TC), two other nucleoside RT inhibitors, combined, again, with either EFV or NFV. If the initial ...
One combination of AIDS drugs appears better for starting treatment
...ombination of zidovudine (ZDV, also known as AZT), lamivudine
(3TC) and efavirenz (EFV) were successfully treated for a longer period of time. "We've been fortunate to have a variety of choices for antiretroviral therapy," says Gregory Robbins, MD, MPH, of the Massachusetts General Hospital. "But many had pre...
Interim analysis comparing TDF to EFV in combination with 3TC + ABC
..."Abacavir is currently approved for BID dosing and lamivudine
is approved for both QD and BID dosing. GSK is developing a co-formulation of lamivudine
and abacavir for once daily dosing. This co-formulation is in late-stage clinical development. Pro...
Study assessing once daily Abacavir (ABC) in a once daily ART regimen
... Abacavir is currently approved for BID dosing and lamivudine
is approved for both QD and BID dosing. Based on...information, GSK is developing a co-formulation of lamivudine
and abacavir that is intended for once daily dosing. This co-formulation is in late-stage clinical ...
Study evaluates Abacavir, Lamivudine and Efavirenz versus Zidovudine, Lamivudine and Efavirenz
...r is currently approved for twice daily dosing and lamivudine
is approved for both once daily and twice daily do...his study, the three-drug combination of abacavir, lamivudine
and efavirenz provided a potent antiretroviral response over 48 weeks and was shown to be non-inferi...
48-week results for the SOLO trial comparing GW433908/r QD to nelfinavir BID
...mbination therapy that included abacavir (ABC) and lamivudine
(3TC). In the final analysis of this 48-week trial data, 68 percent of HIV+ patients achieved undetectable viral load with 908/r compared to 65 percent of patients taking NFV BID in this open label study. The 908 compound was co-discovered by GlaxoS...
Tipsheet on XIV International AIDS Conference
... is important. A combination of zidovudine (ZDV), lamivudine
(3TC), and efavirenz (EFV) appears to be particularly beneficial compared with other three-drug regimens, including the similar combination of ZDV, 3TC and nelfinavir (NFV). Researchers found no evidence of a difference between three-drug regimens u...
Drug combinations reduce HIV levels in untreated patients
...o medications: abacavir (trade name Ziagen) and lamivudine
(Epivir), both from the "nucleoside reverse transc...gimens. The group of patients using abacavir and lamivudine
in combination with an nNRTI (efavirenz) experienced the greatest decline in viral loads, with 75 pe...
Drug cocktail prevents hepatitis B virus from recurring after liver transplant
...reatment of hepatitis B immune globulin (HBIg) and lamivudine
in combination prevents recurrence of HBV infectio...ivided into four treatment groups: no prophylaxis, lamivudine
monotherapy, HBIg monotherapy, or a lamivudine
and HBIg combination. When comparing the combination ...
Antiretroviral therapy around childbirth reduces risk of mother-to-child HIV-1 transmission
...erapy with the antiretroviral drugs zidovudine and lamivudine
in a predominantly breastfeeding population. Around 1800 pregnant women with HIV-1 from South Africa, Tanzania, and Uganda were randomised into four groups: the first group received drug therapy targeting pre-delivery, labour, and post-delivery stag...
The molecular evolution of viral drug resistance
... because of its thousand-fold greater potency than lamivudine
and its ability to suppress replication of even the most vigorous drug-resistant mutants....
New HIV drug intervention cheap and effective
...tested a combination of AZT and the antiviral drug lamivudine
administered late in pregnancy (PETRA, Arm-A) and at labor (PETRA, Arm-B). The model assumed each treatment program was given to 20,000 hypothetical pregnant women in sub-Saharan Africa. It took into account various factors such as rates of HIV infe...
Newly Updated HIV Treatment Guidelines For Adults And Adolescents Available On The World Wide Web
... family of drugs also includeszidovudine (AZT) and lamivudine
(3TC). Clinical trials of abacavir combined with AZT and 3TC have shown that thiscombination suppresses HIV replication and boosts CD4+ T-cell counts to a degreecomparable to widely used treatment regimens that combine a protease inhibitordrug with...
Study Finds Less Intensive Treatments May Not Maintain HIV Suppression
...avir(IDV) in combination with zidovudine (AZT) and lamivudine
(3TC). After six months, more than 300 individuals whose viral loads had been reducedto 200 or fewer copies of HIV RNA/ml of blood were randomized to receive eitherthe same triple-drug therapy as before, a two-drug combination of AZT and 3TC,or mono...
Study Shows Three-Drug "Cocktail" Needed To Keep AIDS Virus Curbed
...cine,indicates the drugs indinavir, zidovudine and lamivudine
curbed human immunodeficiencyvirus (HIV) better th...indinavir, when combined with zidovudine (ZDV) and lamivudine
(3TC) both cut AIDSvirus levels in patients and boosted levels of CD4 cells, the infection-fighting ...
UNC Researchers Find Drug-Resistant HIV In Semen
...s including ziduvodine (ZDV), didanosine(ddi), and lamivudine
(3TC) . Eron, a UNC infectious disease specialist, points to a case report lastsummer in The New England Journal of Medicine of infection with a strain of HIVthat was resistant to multiple antiviral medications. "Our study shows how thiscan h...