Tag: "ligand" at medical news
Chemists Develop Probe To Detect Changes In Imaging Agents Inside Body
...bine a radioactive tracer such as technetiumwith a ligand
or compound that can target the tissue or organ ofinterest. For example, a common application is a heart imagingagent which can detect blockages in blood flow following a heartattack. This information is important to doctors planning follow-up therap...
Discovery Hints At Multitude Of New Targets For Drugs
...eall the processes that it normally produces. If a ligand
changes it intoa 'round' conformation, some of the processes don't care, and they'll continueto operate. But others will not be triggered by a 'round' receptor, andthey'll shut off." For example, he said, the same estrogen receptorinfluences a variet...
Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites
...the ligand'sstructure they will tell you where the ligand
might bind," Toone added. But scientists' pr...er leaving would make a much largercontribution to ligand
binding than scientists had previously imagined,"he added. To prove their conjecture, Toone an...
Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
...ogen action is not asimple on-off signal. When the ligand
occupies its binding site on the receptor,it triggers a change in the three-dimensional shape of the receptor that createsa docking site for either co-activators or co-repressers -- proteins which whenbound enhance or suppress the activity of the rec...
Ph.D. Degree Research Results In Patent For Low-Cost Pharmaceutical Filters Made From Seafood Waste
...r is the process of using beads in separation."The ligand
is a group of atoms that interacts with the target...cule,resulting in attraction. A positively-charged ligand
will attract anegatively-charged protein, for example, since opposite charges attract. Othertypes of...
Yale researcher finds new clue to what blocks nerve fibers from regrowing following spinal cord injury or disease
...rtance of the discovery is that by having both the ligand
and the receptor molecules in hand, it greatly simplifies the search for inhibitors of that interaction and for therapeutic possibilities." Strittmatter and his collaborators a year ago published a study identifying the Nogo protein as one important ...
Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
...tected in nearby cells. The suspect proteins, Fas ligand
(FasL) and Fas, exist in normal brain and blood ve...mune cells. This suggests the possibility that Fas ligand
contributes to a tumor's ability to evade the immune system. Taken together, the studies indicate th...
Decrypting the role of Cripto in tumor growth
...tion reveals that binding of Cripto to the TGFbeta ligand
Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibody blockade of Cripto function may prove useful in the inhibition of tumorigenesis. Cripto was first discovered 15 years ag...
Research offers insight on treatment for hereditary eye disease
...m at the level of the protein then we can design a ligand
or drug to stabilize the abnormal protein to make sure it is destroyed properly." Hwa and colleagues used two techniques to pinpoint the mutations, which enabled them to decipher which of rhodopsin's 348 amino acids were distorted. The first techn...
A spoon full of sugar helps inflammation go down
...duce a new strategy for the inhibition of selectin ligand
production, which blocks E-selectin ligand
expression and therefore ultimately prevents the development of contact hypersensitivity (CHS) respo...
Gene therapy establishes a TRAIL to arthritis treatment
...ng tumor necrosis factorrelated apoptosis-inducing ligand
(TRAIL) was then introduced into these cells. The design of the adenovirus vector allowed the researchers to "switch on" the expression of TRAIL by these gene-modified dendritic cells at their discretion, by the addition of doxycycline (DOX). A casca...
JCI Table of Contents
...llogeneic MHC class I molecules as well as a Notch ligand
from the Delta-like family may be used to repress ... cells are recruited via L-selectin and L-selectin ligand
upregulation on vasculature rejecting the allograft. The study indicates that a specific collection ...
Obesity reversed in mice by destroying blood vessels that service fat cells
...earchers designed a drug. They created a synthetic ligand
- a sequence of amino acids that would fit neatly ... due to oxygen deficiency," says Pasqualini. "The ligand
- the guidance system - brings the therapeutic drug to the prohibitin receptor, where it locks on, a...
Promise of stem cells amplified
...r tumor necrosis factor-related apoptosis-inducing ligand
(TRAIL). This substance, secreted by the implanted stem cells, is like kryptonite to the hazardous tumor cells. The scientists studied the most lethal type of brain cancer: intracranial glioblastomas. Adult mice with the tumors received transplants ...
USF neuroscientists awarded $1.1 million NIH grant to improve Alzheimer's vaccine
...n and Dr. Morgan plan to administer this anti-CD40 ligand
antibody to mice genetically engineered to develop symptoms similar to Alzheimer's disease. The mice also will be immunized with an investigational anti-Alzheimer's vaccine shown to remove beta amyloid plaques that accumulate in the brain, thereby l...
Marine sponge leads researchers to immune system regulator
...activator -- what immunologist call the endogenous ligand
-- for these cells is crucial to understanding their biology, he added, and might provide a gentler and more enduring way to get them to fight tumors. Bendelac's team developed several approaches to identify the endogenous ligand. One crucial clue ca...
Blocking molecules protects health of implants
...ry cells that attack the implant. The CC chemokine ligand
(CCL)-2, previously known as monocyte chemoattractant protein (MCP)-1, is believed to be responsible for the recruitment of foreign body giant cell precursors to the implant site. This study examined what would happen if the expression or function of...
Johns Hopkins scientists receive presidential medals
...beling of receptors by a process called reversible ligand
binding, which led to his and colleagues' discovery of the opiate receptor, and he extended the technique to identify numerous other neurotransmitter receptors in the brain. In characterizing each new group of receptors, he also clarified the action...