Dr. Judah Folkman honored with American Heart Association/Novartis award
...ng the first to grow endothelial cells (cells that line the blood vessels) in a dish. Though seemingly insignificant, the discovery was a breakthrough in medicine leading to a better understanding of how endothelial cell growth fosters cancer and heart disease. Being able to study endothelial cells in a...First-line use of voriconazole yields better outcomes for life-threatening fungal infection
...rstand that the type of therapy selected for first line impacts the patient's chance of survival. These studies showed that patients initially treated with voriconazole had better outcomes and incurred fewer antifungal drug costs than patients treated initially with the prior 'gold standard therapy' amph...Alcohol may compound its damaging effects through frontocerebellar circuitry
... once) and balance (the ability to walk a straight line or stand on one foot, especially with eyes closed or in the dark). Executive functions are typically disrupted by lesions of the prefrontal cortex, whereas balance and postural stability are disrupted by lesions of the cerebellum. "The main idea ex...University of Pittsburgh intestine transplant results reported at international meeting
...hreatening complications such as liver failure and line infections. As such, intestinal transplantation is considered a life-saving procedure that can also have a profound effect on quality of life. More than 80 percent of the patients transplanted at the University of Pittsburgh no longer require TPN and...Exercise and breast-cancer prevention: study finds it's never too late to start
...se bursts of activity, McTiernan said. "The bottom line is that duration of activity is more important than intensity. The turtle beats the hare when it comes to preventing breast cancer through exercise." To get the optimum breast-cancer protection, women should aim for at least 30 minutes of moderate-in...UCSD researchers decipher function of blood-brain barrier in bacterial meningitis
The first line of defense used by the human blood-brain barrier i...e brain, and somehow manage to cross the defensive line of the blood-brain barrier. Using an experimental blood-brain barrier established by growing layer...Subversive strep bug strategy revealed
...infectious organisms never make it past this first line of defense. The broad outlines of neutrophil action were known previously, Dr. DeLeo says, but details have been scarce because the cells are difficult to study. For example, scientists believed that the fate of a neutrophil was set during its matura...Study: Stereotypes prevail in media coverage of depression
... in a prescription." Now, Metzl is continuing this line of study in a way that may reveal whether doctors' own notes on patients with depressive illnesses are also increasingly including non-medical terms and descriptions. He is currently concluding an effort to code the notes in medical charts according ...Educational attainment may predict drinking outcomes following alcohol treatment
...the treatment program that they're in. The bottom line is trying to make treatment optimal for people who are trying to help themselves with an alcohol problem."...Recent study suggests that tooth loss/gum disease may be associated with heart disease
...Oral-B Professional Care 7000 cleans below the gum line to help prevent and even reverse gum disease. The Oral-B Professional Care 7000 is now available in drug, mass, department and specialty retailers in North America at suggested retail prices ranging from $69 to $99. More information can be found b......rally the glue that holds you together. The bottom line is that collagen has been used for centuries as something to repair wounds because it is a natural component of the tissue." But collagen treatments alone "don't bind the wound," Miller said. Miller and the other researchers developed a matrix or ...Alcohol consumption increases HIV disease progression of patients receiving antiretroviral therapy
... may raise these same issues. But that's a future line of research." Justice added that "future studies need to determine the degree to which this association is explained by patient behavior, such as nonadherence, and the degree to which it appears to be a direct effect of alcohol on the immune system o...Enzyme found in blood vessels likely target to treat lung injury
...ug Discovery Training Program. Endothelial cells line blood vessels throughout the body and serve as a barrier to keep toxins in the blood from entering tissues and organs. MLCK 210 regulates normal endothelial cell function, but the contribution of MLCK 210 to the mechanisms of lung injury in the livin...Rice uses buckyballs to reinvent 'antibiotic of last resort'
... world's first targeted antibiotic, creating a new line of defense against bioweapons like anthrax. Vancomycin, which entered clinical service 40 years ago, is the antibiotic of last resort, given only when all others fail. Unfortunately, vancomycin-resistant strains of bacteria have appeared in recent ye...Economic evaluation shows add-on therapy with Keppra(r) is a cost-effective alternative
...efractory epilepsy that has not responded to first line anti-epileptic therapy (AED), Keppra is very important in the management of difficult to treat patients. Seizure freedom is the ultimate aim of treatment for refractory epilepsy, but is rarely achieved in add-on trials for treatment of refractory pa...Brookhaven spotlights: News from the March 2003 American Chemical Society Meeting
...the therapy, "is that the endothelial cells, which line the inner walls of blood vessels, survive in the regions between the microbeams, so they can replace the endothelial cells killed by the microbeams. But this repair process somehow fails in the tumor's capillaries because they are very different from...Unproven prostate cancer screening more popular than valuable colon test
...ool. "We anticipated that if medical care was in line with scientific evidence, then the proven test, colorectal cancer screening, would be more common than the unproven prostate cancer screening, but this was not the case." Sirovich speculates that the PSA test is more popular because it is just a si...Dartmouth/VA study questions screening priorities of prostate and colon cancer
...vich. "We anticipated that if medical care was in line with scientific evidence, then the proven test colorectal cancer screening would be more common than the unproven prostate cancer screening. This was not the case. More men had been tested for prostate cancer than for colon cancer in all but four...San Diego chemist wins national award for innovative drug design
...and vancomycin, the antibiotic considered the last line of defense against highly resistant bacterial infections. His latest achievement came with one of his graduate students, Phil Baran, whom the dual award also recognizes. In an international race to synthesize CP molecules, Nicolaou and Baran were the......te a colleague to nominate him for the award. "The line between drug discovery and drug development was traditionally a strict border -- people in development never worked on a drug until after the company collected huge amounts of data and committed to it," said Reider, now with the biotechnology company...