Tag: "line" at medical news

Spreading cancer survives via signals from nearby blood vessels long before new vessels are grown

...they didn't realize is that endothelial cells that line the blood vessels are also releasing signals back to the cancer cells that protect the cancer cells from dying and direct them to grow toward the blood vessel. In fact, the cancer cells respond to the endothelial cells' messages by elongating and str...

Drug company fees for FDA reviews havent accelerated approvals, study finds

...Dec. 17 by the journal Health Affairs. "The bottom line is that the more staff the FDA has reviewing drug applications, the faster the approval process will be," says senior author A. Mark Fendrick, M.D., of the U-M Medical School and School of Public Health. "If you want more rapid assessment of new drug...

Cancers' love-hate relationship with proteins offers new treatment window

...at shock proteins have on telomerase, we created a line of mice, in which the genes for the proteins were knocked out." Cells lacking the proteins were close to becoming cancerous. Ends of chromosomes in the modified cells were more likely to become associated with each other, indicating the chromosom...

Practice-based intervention improves quality of care for young children

...s specialist-staffed child developmental telephone line to address parents' developmental concerns; developmental assessments; written materials emphasizing prevention and health promotion; parent groups offering support and learning opportunities; and linkages to community resources through targeted refe...

New drug may help cancer patients in need of stem cell transplants, Jefferson trial shows

...r. Flomenberg, stem cell transplantation is "front line therapy for multiple myeloma, or cancer of the bone marrow, and for high-risk lymphoma patients." Approximately 25 percent to 35 percent of transplant patients have trouble moving stem cells from their bone marrow into the bloodstream using the stan...

Altered cyclin E protein leads to genetic instability in breast cancer

... initial diagnosis, Keyomarsi says. Using the cell line model system in this study, led by Said Akli, Ph.D., an instructor in Keyomarsi's laboratory, the investigators found that low molecular weight cyclin E has the ability to make an otherwise estrogen-positive tumor unresponsive to anti-estrogen, endoc...

Obesity risks add to complications of gastric bypass

...ding abdominal cavity and five instances of staple line disruption in the stomach, complications specific to Roux-en-Y. They also observed three incidents of pulmonary embolism, two cases of pneumonia, and single cases of severe infection and open abdominal wound disruption -- all complications that are p...

Gastric bypass surgery is riskiest for those who need it most

... of anastomotic leaks and five instances of staple line disruption in the stomach, complications specific to Roux-en-Y. Three incidents of pulmonary embolism, two cases of pneumonia, and single cases of severe infection and open abdominal wound disruption were also reported complications that are more pr...

Gastric bypass surgery riskiest for those who need it most

... of anastomotic leaks and five instances of staple line disruption in the stomach, complications specific to Roux-en-Y. Three incidents of pulmonary embolism, two cases of pneumonia, and single cases of severe infection and open abdominal wound disruption were also reported complications that are more pr...

New drug to treat enlarged prostate developed at UCL

...tile dysfunction (impotence). The future for this line of research is therefore promising since men with an enlarged prostate often suffer from impotence. " Malcolm Grant, UCL Provost, said: "The conversion of scientific results into new medicines is one of the main aims of the Wolfson Institute for Biom...

Understanding how lymph nodes respond to infection may redefine how immune system functions

...t protect it against invading pathogens. The first line of defense is the innate immune system, a quick-acting response triggered immediately when a pathogen enters the body. The innate immune response responds the same regardless of the pathogen and attacks the pathogen for the first several days until t...

Leading the way in novel anti-cancer research

...normal blood vessels. The endothelial cells which line their vessel walls retain the characteristics of immature, newly formed dividing cells and appear to depend heavily on a tubulin cytoskeleton to maintain their shape. Vascular targeting agents are designed to disrupt this cytoskeleton, causing the e...

St. Paul nurse receives Guardian Angel Award named for UT Southwestern vice president

...iza Young quite a bit about joy and sorrow. "This line of work can be emotionally wrenching, but the fulfillment I get from being a part of the journey these babies take is a wonderful privilege and a great source of happiness for me," said Mrs. Young, nurse manager of the neonatal intensive care unit (N...

Poor neighborhood linked to poor heart attack survival

...h percentage of residents living below the poverty line had a death rate after heart attack 30 percent hig...ool of Public Health in Boston, Mass. The poverty line is an income threshold based on family size, age of children and income. In 1999, the poverty thres...

Immune memory from smallpox vaccination lasts more 50 years, according to Emory research

... 60 years. In humoral immunity, the body's first line of defense against infection is antibodies produced by B cells, which are the primary measure of immunity for most vaccines. Memory B cells are responsible for stimulating a rapid antibody response after re-exposure to infection. In cellular immuni...

Panel: Clinical use of embryonic stem cells jeopardized by Bush's policy on federal funding

...e an equal chance of finding a match in an ES cell line bank aimed at providing clinical treatments. African-Americans have a greater variety of HLA profiles, so more cell lines would be needed in the bank to potentially match the same percentage of that population as, say, white Americans. According to t...

Protein identified that may play central role in inflammatory bowel disease

... expressed primarily in the endothelial cells that line the intestines. When TL1A interacts with DR3, found on active lymphocytes, the body can produce T cells as part of the inflammatory response associated with IBD. Anti-TNF drugs, such as Remicade, are being used to treat people with moderate to sever...

Exercise has a more powerful impact on the brain than previously thought

...y to CD 31, a marker of the endothelial cells that line capillaries. This antibody is commonly used by oncologists in studies of cancer. The volume of brain tissue occupied by capillaries in the exercising monkeys was shown to have increased relative to values in 3 unexercised controls. "The greatest incr...

Jefferson Scientists define new cell type that may lead to clues about Kaposi's sarcoma

...complish this, they have grown and characterized a line of mouse skin cells in the laboratory that they be...endrocytes is that we've never had a purified cell line to study until now," Dr. Murphy. "Now we have a cell line that is purified and expresses a blood clo...

Addressing medical students as 'student doctors' may help quell patient fears

... to appear interested, smart, and punctual all in line with their new "student doctor" status, he concludes....

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