Entrepreneurism Center at UC San Diego funds commercialization of lung, shock, other devices
...: determining the functional variants in each gene locus that is linked to the disease and the effect of functional variants on the regulation and gene products of the gene; and understanding how these intermediate phenotypes affect disease outcomes. Using this information, researchers can identify subtype...Other highlights in the December 1 JNCI
...ial malignant melanoma, but it is not known if the locus is involved in DNA repair. In a new study, Thomas ...he authors conclude that mutation of the INK4a/ARF locus may predispose people to melanoma because of a reduced ability to repair sun-induced DNA damage in a...Researchers shed light on cancer susceptibility using 'supermice'
...alled "tumor suppressors". Of these, the Ink4a/ARF locus has been of considerable interest since this locus is inactivated in a majority of human cancers. This locus encodes two different proteins that act to...News tips from the Journal of Neuroscience
...hmidt Norepinephrine (NE)-releasing neurons in the locus ceruleus provide arousal-associated modulation of sensory inputs throughout the brain. Cardin and Schmidt take advantage of the feed-forward organization between forebrain nuclei in the zebra finch auditory system to examine such state-dependent neur...Jefferson and Michigan scientists identify gene defect behind muscle-wasting disease
...o correspond to mouse chromosome 6, where the mnd2 locus is found he suspected that a mutation in the Omi/HtrA2 gene could be behind the mnd2 disease. According to Dr. Alnemri, who is professor of microbiology and immunology at Jefferson Medical College and a member of Jefferson's Kimmel Cancer Center, Om...Alcohol may compound its damaging effects through frontocerebellar circuitry
...eking them, that is, connecting one cortical brain locus with one behavior, was too simplified and too restricted to the cerebral cortex and excluded brain stem structures such as the pons and cerebellum." Researchers know that two areas of neuropsychological functioning commonly compromised by chronic alc...Parkinsons symptoms indicated for first time on pet scans of brains of living patients
...two small areas found deep in the brain called the locus coeruleus and raphe, areas that control attention and wakefulness. His analysis found positive evidence of degeneration of nerve cells in these areas. "We were able to see changes in these areas for the very first time," Dr. Moore said. "Before now, ...University of Pittsburgh researchers link gene to depressive disorders in women
... "We have narrowed our search for a susceptibility locus for clinical depression to a small region of chromosome 2 that constitutes only 0.01% of the human genome," said lead author George S. Zubenko, M.D., Ph.D., professor of psychiatry at the University of Pittsburgh School of Medicine and adjunct profes...Location of gene for ear wax could increase understanding of apocrine-gland development
...omments: "The region to which we mapped the earwax locus is included in the region associated with paroxysm... close to each other. Identification of the earwax locus could contribute to further anthropogenetic studies and to physiological and pathological understand...Alcohol researchers find genetic locus of human brain wave
...Begleiter are the first to find a specific genetic locus associated with fundamental human brain oscillations. Their work contributes to understanding of brain neuroelectric activity and expedites our search for alcoholism risk and protective genes," said NIAAA Acting Director Raynard S. Kington, M.D., Ph....Female-specific genetic factors that contribute to emotional behaviors
...e but not male rats. Furtherinvestigation of this locus may give clues as to the biological andgender-related mechanisms involved in the development of emotional disorders. Full reference: A Ramos, M-P Moisan, F Chaouloff, C Mormède, P Mormède.Identification of female-specific QTLs affecting......in and stiffness, particularly duringexercise. One locus (location on a chromosome) responsible for RMD has beenpreviously mapped. Dr. Pulst will identify a new one. Wednesday, April 21, 9:45 a.m. "The SCA2 Gene Product, Ataxin-2, Interacts witha Novel Protein, A2BP, a Member of a RNA Binding Gene Family."...