Both inherited traits and tumor mutations affect response to treatment of leukemia
The outcome of chemotherapy treatment for acute lymphoblastic leukemia (ALL) depends not only on the acquired genetic make-up of the leukemic cells, but on genes that children inherit from their parents. This study, from investigators at St. Jude Children's Research Hospital, is published in the online edition ...Methylphenidate improves attention, behavior of children surviving leukemia, brain tumors
...social deficits among survivors of childhood acute lymphoblastic leukemia (ALL) and brain tumors (BTs), the two most common forms of childhood cancer. Previous studies have shown that these children are likely to develop significant cognitive and behavioral problems compared to their healthy peers, according to R...St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
...abdomyosarcoma, Ewing sarcoma, osteosarcoma, acute lymphoblastic leukemia, renal tumors (Wilms and rhabdoid), embryonal brain tumors and glial brain tumors. Each in vivo panel will consist of four-eight xenograft lines. The in vitro panel will represent a similar range of childhood cancers and will include 20-25 c...Improved acute lymphoblastic leukemia treatment offers hope for eliminating irradiation
...proved risk classification for patients with acute lymphoblastic leukemia (ALL), coupled with more intensive intrathecal chemotherapy for high risk patients and the use of a drug called dexamethasone, could one day permit physicians to omit irradiation as a part of routine treatment. These findings emerged from a ...New analysis links breastfeeding to reduced risk of childhood leukemia
...astfeeding was linked to lower risks of both acute lymphoblastic leukemia (ALL), the most common of the childhood cancers, and acute myeloblastic leukemia (AML). "Our paper is the first to systematically review the epidemiologic evidence of the link between maternal breastfeeding and the risk of childhood leukemi...St. Jude helps South American community achieve improved survival rates for leukemia
...vement in outcome among children treated for acute lymphoblastic leukemia (ALL) during the past decade, even though the community is resource-poor and most patient families are impoverished. These findings are published in the May 26 issue of the Journal of the American Medical Association by physicians at St. Jud...Researchers identify leukemia-linked pathway targeted by a new kinase inhibitor
...ronic myelogeneous leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL). In both cancers, enzymes that should regulate the growth and development of white blood cells go awry, resulting in uncontrolled growth of the cells. The Swiss-based pharmaceutical company Novartis developed Gleevec, the first kinas...Molecular analyses of leukemia patients suggest strategies for better treatments
The cure rate for pediatric acute lymphoblastic leukemia (ALL) might continue to rise with improved use of conventional therapies. But even more effective and less toxic therapies based on genetic and pharmacogenetic studies might one day push the success rate close to 100 percent, according to an...Comprehensive gene profiles hold promise for improving outcome of pediatric leukemia
...gerprints of the major subtypes of pediatric acute lymphoblastic leukemia (ALL), the most commonly treated pediatric cancer. The achievement promises to enhance the ability of physicians to more accurately diagnose ALL, improve their ability to accurately monitor a patient's response to therapy, and eventually, de...St. Jude leukemia therapy overcomes differences in treatment outcome between black, white children
...ldren to benefit from improved treatment for acute lymphoblastic leukemia (ALL), if given equal access to the most advanced therapies. This finding--that black and white children had virtually equal rates of survival over 10 years--contrasts with the results of clinical studies from the Pediatric Oncology Group (...More than $34 Million in SPORE Grants
... including acute myelogenous leukemia (AML), acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and myelodysplastic syndrome (MDS).Monies from the five-year, $12.75 million SPORE grant, the first ever SPORE to be funded for leukemia, will examine the genetics, biology, and markers unique to...Gene expression profiling may lead to customized treatments for pediatric leukemia patients
...rs accurately identify subtypes of pediatric acute lymphoblastic leukemia (ALL), according to the October 15, 2003,...kelihood of responding to therapy. Pediatric acute lymphoblastic leukemia has a number of subtypes, each with unique cellular and molecular characteristics. Since t...In childhood leukemia study, aggressive chemotherapy cuts deaths by 37%
...chester. It focused on children with T-cell acute lymphoblastic leukemia, or T-ALL, which accounts for 15 percent of all childhood leukemia cases and is fatal in nearly four in 10 children. While dozens of drugs are routinely used to treat children with the disease, the study sheds new light on the fundamental ...St. Jude identifies ways to improve treatment of childhood leukemia in Honduras
...ts and cure rates for Honduran children with acute lymphoblastic leukemia (ALL). Their findings are published in the August 30 issue of The Lancet. Many children in Honduras receiving the most advanced treatment for ALL, the most common type of childhood cancer, still die because their families must abandon therap...Childhood leukemia survivors not receiving radiation have same life expectancy as general population
...spital indicates that survivors of childhood acute lymphoblastic leukemia (ALL) who have not received radiation treatment as part of their therapy have virtually the same long-term life experiences as the general population. The findings, which appear in the August 14 issue of the New England Journal of Medicine,...Women cured of childhood leukaemia should be advised to have children while they are young
...nmark, has studied 26 long-term survivors of acute lymphoblastic leukaemia (ALL) and found that they tended to have...ncreased long-term survival of children with acute lymphoblastic leukaemia, but the treatment can induce late effects. It is well known that a proportion of the pat...Childhood cancer survivors: Good health for some, long-term complications for others
...western, reveals that survivors of childhood acute lymphoblastic leukemia are significantly more likely to be overweight or obese when compared to siblings. Female survivors treated with cranial radiation before the age of five years were four times more likely to be obese, while male survivors were twice as likel...Genetic test for cell-proliferation enzyme could improve treatment of acute lymphoblastic leukaemia
...ts at an increased risk of poor outcome from acute lymphoblastic leukaemia. The enzyme thymidylate synthase is ass... of thymidylate synthase) and the outcome of acute lymphoblastic leukaemia in 205 children treated with methotrexate. DNA samples from patients were analysed for va...Costly cancer treatment aimed at protecting kids hearts offers no additional benefit
...unproven theory that children suffering from acute lymphoblastic leukemia might suffer less heart damage if treated...cians believed that giving children who have acute lymphoblastic leukemia - the most common type of cancer in young children - a lower peak dose of the widely used c......nce rates of acute myeloid leukemia overall, acute lymphoblastic leukemia overall, and specific acute lymphoblastic leukemia immunophenotypes were remarkably stable in these countries during the past two decades. T...