Researchers uncover gene related to acute leukemia
...e are associated with both acute myeloid and acute lymphocytic leukemias.Whereas previous models held that inv(16) simply kept AML-1 from doing its jobof turning genes on and off, Hiebert and colleagues now demonstrate that inv(16)joins with AML-1 to actively turn genes off, even those that AML-1 usually turnson...Jefferson scientists create first animal model of common type of leukemia
...lecular mechanisms underlying the disease, chronic lymphocytic leukemia (CLL), while at the same time provide a testing ground for potential new drugs. "This is a very important discovery because now we have an animal model to use to develop and test new drugs," says Carlo Croce, M.D., professor and chair of mic...Virus that can infect both mice and humans is driven to extinction with cancer drug
...ation-inducing cancer drugs in cells infected with lymphocytic choriomeningitis virus (LCMV), a virus that can infect both mice and humans. To do this, the investigators infected hamster cells, grown in culture, with the virus and treated them with either 5-fluorouracil (FU) or 5-azacytidine (AZC). The viruses...No significant rise in cancer deaths in 3-Mile Island residents over 20 years, says Pitt
...c tissue (blood-forming organs), excluding chronic lymphocytic leukemia and Hodgkin's disease; and the central nervous system. Thyroid cancer was considered, but only one death was reported during the study period. Researchers used information collected by the Pennsylvania Department of Health in interviews cond...More than $34 Million in SPORE Grants
...L), acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), and myelodysplastic syndrome (MDS).Monies from the five-year, $12.75 million SPORE grant, the first ever SPORE to be funded for leukemia, will examine the genetics, biology, and markers unique to leukemias so new targeted therapies ma...Molecule expressed early in pregnancy may help patients tolerate transplants
... same thing. "We will be giving a double whammy of lymphocytic depletion plus dendritic cell injection," said Dr. Horusko. One of the many difficulties will be finding the optimal mechanism for inducing the desired, localized suppression. "I believe the future will be injection of a few cells to induce a specif...Drug prolongs lives of chronic lymphocytic leukemia patients
...ly prolonged the lives of some people with chronic lymphocytic leukemia (CLL), the most common form of leukemia in adult Americans. The findings come from a comparative analysis of two completed national phase II and phase III clinical trials that will be presented Dec. 8, 8:00 a.m. PT, at the 45th ...Gleevec shows promise in treating another form of leukemia
...treating a different blood cancer, a type of acute lymphocytic leukemia (ALL). Researchers at The University of Texas M. D. Anderson Cancer Center have found that when Gleevec is paired with high-dose chemotherapy, patients with Philadelphia-positive ALL have a more durable response than if they were treated wit...Mayo Clinic researchers discover green tea component helps kill leukemia cells
...lls studied were from patients with B-cell chronic lymphocytic leukemia (CLL) -- most often diagnosed in patients in their mid-to-late 60s. Currently, there is no cure for CLL, though chemotherapy is administered in the most severe cases. The Mayo Clinic study, led by Neil E. Kay, M.D., shows that green tea's EG...$5 million grant awarded to U.VA health system targets leukemia drug development, creates new jobs
...cells. The disease is divided into myelogenous and lymphocytic leukemia, each of which can be acute or chronic. About 33,440 new cases of leukemia will be diagnosed in the U.S. this year, mostly in older adults. However, leukemia makes up about 30 percent of all cancers in children. The relative five-year surviv...Longterm immune memory cells cells do not develop during chronic viral infections
...y researchers used a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) to study the differences in CD8 memory T cell immune response following acute and chronic infections. In mice with the acute infection, the virus was cleared by a CD8 T cell immune response within one week. In mice wit...Obesity linked to another cancer - leukemia in older women
...ia 74 were diagnosed with AML and 88 with chronic lymphocytic leukemia (CLL). "We found that the risk for getting AML was 90 percent higher in overweight women age 55 and older who had a body mass index (BMI*) of 25-29," says Julie Ross, Ph.D., associate professor of pediatrics at the University of Minnesota M...Novel drugs help solve Gleevec resistance
...tant CML patients, but also in patients with acute lymphocytic leukemia (ALL) associated with the "Philadelphia chromosome." The AMN107 Phase I study has accrued 65 patients since opening in May 2004. Even though an optimal dose has yet to be established as no significant toxicities have yet been encountered, mo...New tipifarnib (R115777) data in AML presented at American Society of Hematology Annual Meeting
...otoxicity of tipifarnib in pediatric AML and acute lymphocytic leukemia samples. Abstract 1172 Monday, December 6 Two abstracts on pharmacoeconomic data related to AML in the elderly. Abstracts 3142 and 3154 Publication only Fas antigen (CD 95) in clonogenic AML and in vitro sensitivity to tipifarn...More than half of relapsed CLL patients respond to two biologics with chemotherapy
...sed with the most common kind of leukemia, chronic lymphocytic leukemia (CLL), researchers from The University of Texas M. D. Anderson Cancer Center report at the annual meeting of the American Society of Hematology (ASH). The researchers combined two different monoclonal antibodies, alemtuzumab (Campath-1H) and...