Aspirin's target, the COX-2 enzyme, linked to cancer of the uterus
...ty and a member of the UIC Cancer Center, cultured malignant epithelial cells from the lining of the uterus alo... of tissue. In the interaction between normal and malignant cells, the malignant tissue induced the normal tissue to increase production of the enzyme cyclooxyd...Brain tumor therapy needs longer treatment time
...ndency to spread aggressively, forming clusters of malignant cells far from the main tumor. While the main tumor mass can be surgically removed, the small clusters of invading cancer cells eventually will grow and form new tumors. In order for treatment to be successful, not only the main tumor mass must be er...FINAL ALERT: RPB Science Writers Seminar in Eye Research to be held in Washington, DC Sept. 22-25
... tailored to target and induce death-by-suicide in malignant cells only. RETHINKING AMD. "Informed speculation," researchers call it. But now there's a growing body of tantalizing evidence to suggest that age-related macular degeneration, the leading cause of blindness in aging Americans, may be at root ...Making cancer cells susceptible to therapeutic attack
...sicians may one day be able to alter the resistant malignant tissue itself, making it vulnerable to therapy. "E...s factor attaches to receptors on the surface of a malignant cell, preparing the way for a full-scale attack, the cancer cell typically blocks the assault. But w...Other highlights in the September 18 issue of JNCI
...cts of CD40 ligation on the survival of normal and malignant human urothelial cells that express CD40. They fou...y be a useful therapeutic approach for eliminating malignant urothelial cells. They add that the loss of CD40 expression by urothelial cells may be important in ...New data may alter frequency and surgical procedure
...t surgery -- if a breast abnormality is benign or malignant and, if they have early breast cancer, whether or ...s that have shown that MRS can identify benign and malignant tumors and the presence or absence of lymph node involvement with a high degree of accuracy. Clinic......sms of how inactivation of the BRCA1 gene leads to malignant cell growth is not fully understood. Paul Harkin and Richard Kennedy from Queens University, Belfast, UK, and colleagues examine the mechanisms that underlie inactivation of BRCA1 and assess how they affect the management of patients, in terms of bo...Exposure to atomic bomb radiation associated with nervous system tumors
...rds, and death certificates to identify benign and malignant tumors of the primary nervous system and pituitary gland that were diagnosed between 1958 and 1995 in 80,160 Japanese atomic bomb survivors. Study pathologists reviewed the records to confirm the diagnoses. The authors found that radiation exposure...Researchers track elusive brain tumor cells in mice with neural stem cells modified to deliver IL-12
...ly been extremely poor for patients diagnosed with malignant gliomas. These tumors have very poorly defined mar...r recurrence and improve survival in patients with malignant gliomas. "The current focus of experimental neural stem cell therapeutics is primarily based around ...UCSD cancer researchers develop new anti-leukemia strategy
...and orchestrate the immune response to infected or malignant cells.) The details of this approach, generally known as adoptive immunotherapy or cellular therapy, are reported in the October issue of the journal Biology of Blood and Marrow Transplantation. "For reasons that are not yet entirely clear, leukemia ...Periodontal examinations could save lives
...roke or heart attack by examining and diagnosing a malignant lesion on his gums. Unforeseen complications after the removal of a cancerous tumor lead to the subsequent diagnosis of protein S deficiency, a disorder whereby the body's natural- occurring anticoagulants are not able to prevent blood clotting. "Id...Scripps Research Institute group designs DNA vaccine that inhibits growth of cancerous tumors
...etastasizeand migrate through the bloodstream--the malignant carcinoma that claims so many lives every year. In recent years, some novel approaches to treating cancer have generated interest in scientific circles and society at large. One of these approaches to is to try to block the process of angiogenesis, t...Herpes simplex virus-2 may increase risk of cervical cancer
... inflammation contribute to the development of the malignant phenotype and may suggest novel approaches to the prevention of cervical neoplasia," they say....UIC research suggests new way to stop growth of cancer cells
...amaged or inappropriately activated genes in human malignant tumors. Miele's research builds on that discovery. His findings show that when damaged or excessively activated in human cells, Ras, through gamma secretase, activates a protein known as Notch-1, which in turn triggers a chain of events that allow c...Human cytomegalovirus may be involved in colorectal cancer
...t cellular processes with the potential to promote malignant growth, particularly affecting colorectal cancer-cell development. Charles S Cobbs from the Birmingham VA Medical Center and University of Alabama, Birmingham, USA, and colleagues assessed whether gene products of human CMV could be detected in color...Smart virus eliminates brain cancer in animal experiments
...a-24-RGD, is thought to be the first treatment for malignant glioma, the deadliest form of brain cancer. It is ...nd protein product that malfunctions in nearly all malignant gliomas as well as in many other solid tumors the retinoblastoma (Rb) protein. Found in all cells o...Other highlights of the May 21 JNCI
...may play a role in susceptibility to melanoma, the malignant form of skin cancer. Elena V. Sviderskaya, Ph.D., and Dorothy C. Bennett, Ph.D., of the St. George's Hospital Medical School in London, United Kingdom, and their colleagues examined melanocytes (pigment producing cells) taken from two patients with m...MIT, hospital begin cancer trials
...f a cancer treatment that could selectively target malignant tissue while reducing the likelihood of injury to ... the world. All three cancers are characterized by malignant cells that have proven difficult to eradicate with conventional forms of radiation. "For these cance...UCSD researchers determine mechanism for degradation of G proteins
... known to cause pathological conditions, including malignant transformation. "As usual with scientific projects like this one, you have to go much more into the details of the mechanism," Farquhar said. "We have a number of experiments now underway to firm up the precise mechanism." "Discovery is finding som...Cedars-Sinai researchers detail events that enable brain tumors to weaken immune system
... describe a complex cell-level process that allows malignant brain tumors to protect themselves by damaging the...ulation of "types" of T cells found in aggressive, malignant tumors was out of balance compared to the response seen in benign tumors. Benign tumors had a high p...