Other highlights in the August 6 issue of JNCI
...ma, actinic keratoses, and cutaneous metastases of malignant melanoma. To study the mechanism by which imiquimod induces apoptosis, or cell death, in cancer cells, Michael P. Schn, M.D., and Margarete Schn, Ph.D., of the Rudolf-Virchow-Center for Biomedical Research at Julius-Maximilians-University, Wrzburg, G...New brain cancer treatment extends survival for more patients
...poside, given together for patients with recurrent malignant glioma, the most common brain tumor in adults. Each of the drugs, which have been approved by the Food and Drug Administration, has been used separately with some success. But Korones noticed that laboratory data showed synergies between the two medi...Early detection of lung cancer possible with CAT and PET scans
... of 20 of the indentified cancer cases. Removal of malignant tissue was achieved in 95% of lung cancers. Ugo Pastorino comments: "We have shown that low-dose spiral CT combined with selective use of PET can effectively detect early lung cancer. A more conservative approach to very small CT-detected nodules is ...New model predicts likelihood of prostate cancer prior to biopsy
...dentified independent risk factors associated with malignant biopsies. The data revealed four independent predictors of a positive biopsy: elevated PSA density, abnormal digital rectal exam, abnormal/hypoechoic transrectal ultrasound and age greater than or equal to 75. Patients younger than 75 with normal DRE...... transplantation is commonly used for a variety of malignant disorders such as leukemias and lymphomas. However, it is also used for a number of other diseases such as immune deficiency states and non-malignant blood disorders. Dr. Bishop will discuss current research efforts that focus on increasing the appli...18F-FLT more accurate than 18F-FDG for differentiating unclear lung lesions
...nfirmed that eighteen of the patients involved had malignant tumors, and eight had benign tumors. Using standar...er specifically designed to reveal the presence of malignant tumors, is better at differentiating cancerous growths from other lesions. While the results show pr...Detection of glycoprotein could indentify ovarian and uterine cancers with poor prognosis
...ancer-related deaths for women with gynaecological malignant disease. The prognosis for women with uterine canc...oprotein) known to be involved in the spreading of malignant tumours was associated with the development of aggressive tumours for uterine and ovarian cancer. T...Promise of laparoscopic liver resection for liver cancer explored in unique program
...er masses, while the remaining cases have been for malignant tumors. Whether removing benign or malignant tumors, surgeons at UPMC and elsewhere consider the laparoscopic approach only if the tumors are loc...Study finds even healthcare professionals are sun worshipers
...eir universally high awareness of risk factors for malignant melanoma," she said. "The implication behind preve...archers interested in studying the epidemiology of malignant melanoma the most dangerous form of skin cancer. SAMPLE comprises more than 30 questions related t...US prostate cancer deaths down one third in men aged 5074: Europe following?
...fragments from being stimulated into becoming more malignant and dangerous by the body's own sex hormones. Randomised trials have shown that, following successful surgery, a few years of hormonal treatment substantially reduces the 10-year risk of death from prostate or breast cancer. The most widely used an...Antigen targeted in therapy for melanoma also prompts immune response in brain tumor cells
...e activity also was detected in four patients with malignant brain tumors who were part of a clinical trial at the Maxine Dunitz Neurosurgical Institute. Cytotoxic T lymphocyte activity was significantly increased after three dendritic cell vaccinations, and the patients appeared to have no adverse effects fro...Contrast mammography reveals hard-to-find cancers
...ight new blood vessel development that accompanies malignant growth. Two images are taken at different energy levels and subtracted from one another to disclose the tumor. Similar techniques are being successfully employed in other areas of radiology. "We expect that dual-energy, contrast-enhanced digital su...Benchmark study of brain tumors points to resection over biopsy as one key to survival
...ur-year study of 560 patients newly diagnosed with malignant gliomas support the finding that resection is a st...d the overall clinical management of patients with malignant gliomas and the patients' satisfaction through their course of treatment. The study was led by physi...Cancer risk calculated with Pap test every 3 years; found comparable to male breast cancer
...Pap test is the standard way physicians screen for malignant cells or cell changes that might develop into cervical cancer. Since its widespread adoption in the 1960s, health care providers have performed the Pap test primarily as part of a routine annual pelvic exam. The major goal of screening is to identif......estigators at M. D. Anderson are testing Iressa in malignant brain cancer and are poised to study it in a numbe...different ongoing clinical trials in patients with malignant gliomas who have failed other treatments. Those trials, by the seven centers within the North Americ...In lab studies, blocking expression of gene reduces invasion of deadly brain tumor cells
... gene was significantly upregulated in high-grade, malignant brain tumors called glioblastoma multiforme (GBM). They theorized that this increased activity might be a critical step in the development, progression and spread of these highly aggressive tumors. Now, in laboratory experiments designed to mimic the...Beckman Laser Institute to improve breast cancer detection
...es detecting early disease, distinguishing between malignant and benign lesions, and understanding the impact of therapies." Researchers at the Beckman Laser Institute and elsewhere have already found laser breast imaging to be particularly effective in detecting tumors in the denser breast tissue of pre-menop...Stem cell factor: Secret to liver's fountain of youth
...hich is often employed in the removal of benign or malignant tumors, a large reservoir of stem cell factor (SCF) in the liver drives increased hepatocyte proliferation in order to restore liver mass to normal. Lisa Colletti and colleagues from the University of Michigan report their findings in the November 3 ...Early promise of blood marker to detect mesothelioma
...entify people with mesothelioma-the usually deadly malignant tumor of mesothelial tissue surrounding the lungs, often caused by exposure to asbestos. Bruce Robinson from Sir Charles Gairdner Hospital, Perth, Australia, and colleagues developed a test to assess blood concentrations of proteins expressed by mes...Age-related outcomes, immune response in patients with brain tumors linked to thymic cells
...eat and study cancers, such as a type of incurable malignant brain tumor called glioblastoma multiforme (GBM), ...ls in 44 patients with GBM, the most aggressive of malignant brain tumors called gliomas. Twenty-four of these patients were newly diagnosed, while 18 had recurr...