Targeting cell fusion as possible way to repair organs, deliver cancer vaccines
..., stem cells are used to repair damage in the bone marrow and to different organs such as the liver, brain and heart. Recent research shows that some of the stem cells' repair properties come from their ability to fuse with cells that are naturally resident in the organs they are repairing. "For example, ...Insulin-producing cells found in a variety of tissues in diabetes
...been unexpectedly found in the fat, liver and bone marrow of diabetic mice, said researchers at Baylor College of Medicine (BCM) in a report that appeared today in the Proceedings of the National Academy of Sciences. "In fact, the appearance of insulin-producing cells occurs in both type 1 (juvenile) and ty...Mayo Clinic discovers important clue to new treatments for lymphoma, breast and colon cancers
...s group of cancers because it involves blood, bone marrow and lymph nodes. In general, it is one of the more common cancers and it is increasing in the United States. Each year about 50,000 Americans are diagnosed with some form of lymphoma, and another 30,000 die from the cancer. Background Analogy: Cance...Fat: It isnt always bad for the heart
...e most commonly found for medical purposes in bone marrow and umbilical cord blood. In addition to their stem cell-like properties, stromal cells in fat tissue make significant amounts of growth factors that enhance angiogenesis, the natural growth of blood vessels. Drs. Rehman, March and the IU team ide...Progenitor cells predict heart disease severity
...come of aging is an unexpected failure of the bone marrow to produce EPCs needed to repair and rejuvenate arteries exposed to a genetically induced risk of high lipid levels. The researchers demonstrated that an age-related loss of these particular cells is critical to determining the onset and progression ...Combination of toxin and poison may be novel treatment for leukemia
...tic leukemia (APL), a cancer of the blood and bone marrow characterized by unhealthy myeloid or white blood cells. The method in which arsenic kills cancer cells, however, was not fully understood until Johns Hopkins scientists used molecular studies to track the poison's target to NADPH oxidase, an oxyge...Blood-forming stem cells fail to repair heart muscle in Stanford study
... groups had reported that stem cells found in bone marrow could lodge in the heart and repair muscle damaged... research. "If we are delivering bone marrow to patients with the expectation that it will regenerate the heart, that may not be realistic," Bals...Powerful stem cells harnessed to search for cancer metastasis
...these cells are capable of migrating from the bone marrow or blood circulation selectively into tumors and produce anti-tumor agents only at the sites of these tumors and their metatasis." ...An alternative to bone-marrow donation
...chers have developed a method to reconstitute bone marrow and blood cells from embryonic stem (ES) cells. As...res. Injection of the selected cells into the bone marrow of mice that had been depleted of their own bone-marrow cells resulted in restoration of blood cells...New therapeutic approach for sickle cell disease
...cer drug hydroxyurea, blood transfusions, and bone marrow transplantation. Hydroxyurea is widely used to reactivate the production of gamma globin, which substitutes for the defective component of hemoglobin, called beta globin. Although this approach does not cure the disease, it frequently results in a le...Embryonic stem cells induced to develop into bone marrow and blood cells
...o induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, includi...When 'switched on' muscle stem cells morph to resemble nerve cells
...l stem cells primarily has been studied using bone marrow cells, but mouse experiments that suggested these .... Some investigators suspect that manipulated bone marrow cells are either contaminated with neural stem cells or get fused with neuronal stem cells present ...Successful therapy for head and neck cancer may lead to long-term circulatory problems
...s (nausea, vomiting), days (erythema), weeks (bone marrow supression), months (fibrosis), and years (carcinogenesis). Among survivors of the cancer itself, late effects on "bystander" organs -- such as the thyroid and salivary glands -- have become increasingly prevalent, with secondary malignancies and inf...Newborn testing for immune disorders could save lives
...n, so they cannot reject the transplants. The bone marrow is processed to remove T cells, preventing the don...he oldest is 22 years of age. All 15 recipients of marrow from perfectly matched donors and 89 of the 121 recipients of T cell-depleted marrow from related do...First randomized trial of adult stem cell injections in heart failure patients shows benefit
...sia, those selected to receive stem cells had bone marrow removed from their hipbones. While bypass surgery was taking place, the particular stem cells that influence blood vessel and heart muscle growth (CD34+ and CD45- cells) were isolated from other cells in the bone marrow. After the bypass was complete...Northwestern Memorial tests 'pacemaker' for stomach
...urology and neurosurgery, oncology, organ and bone marrow transplantation, and womens health. Northwestern Memorial was ranked as the nations 5th best hospital by the 2002 Consumer Checkbook survey of the nations physicians and is listed in the majority of specialties in this years US News & World Reports ...Early signs that adult bone-marrow stem cells could regenerate brain tissue
...Dr. Scott comments: "This study suggests that bone marrow could be used as a therapeutic source of readily harvestable cells for the regeneration of nerve cells, with potential application to various neurodegenerative diseases and traumatic central nervous system damage"....SMASH imaging increases effectiveness of MRI for musculoskeletal imaging
..., a technique that allows better detection of bone marrow abnormalities. They found that using SMASH imaging decreased examination time by more than eight minutes on each knee examination. "The benefits of this time savings is that patients tolerate the procedure better--there's no claustrophobia, they can...Preimplant test offers option of having child to serve as stem cell donor to sibling in need
...or stem cell transplantation in siblings with bone marrow failure. The study consisted of HLA matching proce...ng for couples having a child affected with a bone marrow disorder, who may wish to have another child as a potential HLA-matched donor of stem cells for tran...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
..." program in patients. His idea was to modify bone marrow cells, in patients who had either breast or ovaria... the low amount of the vector taken up by the bone marrow cells. Roth, now chairman of the Department of Thoracic and Cardiovascular Surgery, had more success...