Researchers report early success using saliva to detect oral cancer
...hatever we found in saliva, we looked to see if it matched our data in blood." As presented in their current Clinical Cancer Research paper, the scientists extracted the mRNA from the saliva of the cancer patients and soon discovered 1,679 genes were expressed at significantly different levels in the cancer ...Four teams awarded inaugural translational cancer research grants
... recipient grants of $300,000 over three years are matched by the institutions from all available sources, creating a total project commitment of $600,000 for each award. A project team must have a minimum of two scientists from the same facility and the team must possess basic and clinical research experti...Drinking and spousal abuse by male US Army soldiers
...e compared with that of 21,786 "controls" who were matched on gender, rank, marital status and had also completed an HRA. "We chose to focus on Army soldiers primarily because we have extensive data available to study them both before and after the abuse event," said Bell. "We were able to examine the stabi...U of MN researchers set new standard of care for adult cord blood transplant patients
...estroyed, and then transplanted with two partially matched umbilical cords. The matching criteria is less stringent in cord blood than bone marrow. All of the patients engrafted successfully with cord blood cells with a low incidence of serious transplant complications and very promising survival compared ...Novel drugs help solve Gleevec resistance
..."Also exciting is the fact that clinical responses matched very well to preclinical testing in animal models. A specific mutation that was resistant to BMS-354825 in the test tube and the animal model was associated with resistance in patients, whereas the other mutations did not induce resistance in the tes...Imaging tool may help physicians diagnose bipolar disorder
...s or drugs and 21 individuals without the disorder matched to each bipolar patient by age, sex and right- or left-handedness. Study participants ranged from age 18 to 54 and included 26 women and 16 men. Using MR spectroscopy, a special form of MR imaging that allows researchers to analyze the chemical...Leukemia patients survive with stem cell transplant
...year require a bone marrow transplant, but have no matched relative or can't find a match in the national bon...33 percent) for those bone marrow transplants with matched unrelated donors. Survival rates were the same (22 percent) for cord blood and one antigen-mismatche...Chronic back pain shrinks 'thinking parts' of the brain, study finds
...articipants with chronic back pain with those from matched normal subjects. All participants with chronic back pain had unrelenting pain for more than a year, primarily localized to the lumbosacral region, including buttocks and thighs, with or without pain radiating to the leg. The participants were div...Cocaine addicts show reduced brain structure that underlies judgment
...ers scanned the brains of 27 cocaine addicts and a matched group of nonaddicts. The scans were done using magnetic resonance imaging, a widely used technique in which harmless magnetic fields and radio signals are used to create three-dimensional images of the brain. The researchers used data from the brain ...Imaging study finds a structural difference in the brains of cocaine addicts
...ilar images gathered from 27 healthy controls, who matched the addicts in a number of variables. The amygdalas of cocaine addicts were found to have significantly less volume than those of the healthy controls, reductions that consistently applied to specific areas. Several characteristics of the changes ob...Developmental issues among triplet infants
...singletons (138 infants) from birth to 1 year. We matched groups for medical (e.g., gestational age, birthweight, medical risk) and environmental conditions (parent age and education, support system). We observed infants and their parents at birth (or before discharge from the hospital if the child was bor...News tips for Tuesday, November 9, 2004
...flights in a group wearing "flight socks" and in a matched group of stocking-less controls. Below-knee DVTs were found in 1.1 percent of the stocking-wearers, while in the non-stocking group 4.6 percent had a DVT and 3.4 percent had a superficial blood clot. Researchers said the difference in the mostly as...Coronary stents do not improve long-term survival
...reatment at Duke. The researchers identified 1,288 matched pairs of patients who underwent either balloon angioplasty alone or stenting -- yet all had a similar likelihood of receiving a stent based on their clinical and demographic characteristics. The patients, 63 percent of whom were male and who had an a...Twenty-Year prospective study of pregnant women with inflammatory bowel disease finds healthy babies
...h.D. Dr. Habal and his colleague Dr. Samir Grover matched 138 women with IBD who gave birth with 83 non-pregnant females with IBD and 100 healthy pregnant females. They measured pregnancy outcomes for the mothers including relapse of IBD symptoms, and fetal outcomes, which included mean birth weight and co...Blood transplants may be more harmful than bone marrow transplants in pediatric leukemia patients
...arrow for transplantation in these patients when a matched sibling donor is available," said Mary Eapen, MBBS, MS, Assistant Professor at the Medical College of Wisconsin and lead author of the study. "The higher rates of mortality observed after PBSC transplantation compared to bone marrow transplantation s...Obese patients have higher health care costs than nonobese patients
...care costs in 539 obese and 1,225 nonobese people, matched by age (within five years), sex, and primary outpatient medical office. Age and sex distribution were similar in both groups. The average age of the obese group was 48.2 years, and the average age of the nonobese group was 49.1 years. The average BMI......with type 2 diabetes and end-stage kidney disease, matched with 310 unrelated Caucasian subjects who do not have diabetes. The results were confirmed in a second completely independent group of 275 Caucasians with diabetes who are participating in the Diabetes Heart Study and a 200-person control group. The...New protein associated with aggressiveness in breast and ovarian cancer
...arker of tumor behavior, they say. The researchers matched tumor samples to outcomes in about 100 patients diagnosed with either breast or ovarian cancer and found that a low level of Rab25 protein on a patient's cancer sample was associated with a better clinical outcome in both cancer types. For example, p...Infection, not lack of oxygen, plays larger role in premature infant brain injury
...rth. Using control cases without brain injury and matched by length of pregnancy, the researchers studied several factors believed to play a role in causing brain injury, including multiple births, lack of oxygen, and the presence of infections. Overall, the researchers confirmed previous research that show......red strokes. For their analysis, researchers matched each of the 179 women to two other stroke-free women who had been diagnosed with breast cancer at the same age and during the same year. Researchers found that use of tamoxifen was not associated with risk of stroke, either overall or when grou...