A marker for new blood vessel formation in tumors
...aubner and colleagues' work, in a mouse with human melanoma and in a small study of patients with tumors including melanoma, suggests that the marker is truly reflecting the in vivo level of the integrin. Hence the marker could be used to identify tumors that express this marker, assess the degree of new vess...Targeting mutant B-Raf protein reduces melanoma development
... mutated gene in melanoma, called v599EB-Raf, aids melanoma tumor development demonstrating its importance as ...ant v599EB-Raf protein could prevent the spread of melanoma and halt tumor growth for those melanomas containing the B-Raf mutation," said Gavin P. Robertson, P...Pathogen-mimicking vaccine as strategy for cancer therapy
...with a synthetic peptide (protein fragment) from a melanoma antigen known as Melan-A/MART-1, induced CD8+ T cells that specifically recognized cells displaying Melan-A/MART-1 on their surface. This T cell response occurred in all eight patients in the trial. Responses were one order of magnitude higher than t...Two studies find evidence that sunlight may have beneficial influence on cancer
... for melanoma. The incidence of and mortality from melanoma have been increasing over the last 50 years in all...rge Caucasian populations. But as the incidence of melanoma increases, so does survival, suggesting the possibility that increasing sun exposure increases melan...Jump-starting T cells in skin cancer
...an be detected in the blood and the tumors of many melanoma patients, and yet these cells are unable to kill the tumor. What causes the impotence of these T cells is a mystery. Equally mysterious is why vaccination against tumor-specific proteins sometimes causes tumor regression without expanding large num...Scientists identify protein critical to melanoma growth
... of Cancer Cell , suggest that drugs that cut off melanoma cells' supply of the protein, called CDK2, might c...s compared to standard chemotherapy. Working with melanoma cells grown in the laboratory, the researchers, led by David E. Fisher, MD, PhD, Director of the Mel...USC researchers highlight disparities in cancer rates among racial and ethnic groups in California
... among non-Latino whites increased so rapidly that melanoma now ranks in the top five cancers for men and women. Increased screening may contribute to the rising trend. Lung cancer death rates increased among women of all races and ethnicities. Thyroid cancer rates increased steadi...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...ein in skin cancer cells could significantly stall melanoma tumor development and increase the sensitivity of ...ctivity can reduce the tumor-creating potential of melanoma cells by making the cancer cells more likely to respond to signals that tell them to die," said Gavi...Add an 'E' to the alphabet for identifying melanoma
... appearance. This is especially true for a type of melanoma called nodular that doesn't fit neatly into the AB...y's Pigmented Lesions Section. Nodular melanoma accounts for 10 to 15 percent of all melanomas. One of four basic types of melanomas, the nodular fo...Other highlights in the December 1 JNCI
...on of the INK4a/ARF locus may predispose people to melanoma because of a reduced ability to repair sun-induced DNA damage in addition to the loss of tumor suppressor function. Contact: Thomas M. Rnger, Boston University School of Medicine, 617-638-5551, truenger@bu.edu Also in the December 1 JNCI: Some ...Learning to cover up reduces risk of skin cancer
...in the United States. The incidence of one type -- melanoma -- is rising, due in part to increased exposure to ultraviolet radiation from the sun. Staying in the shade, keeping out of the midday sun and wearing protective clothing can reduce ultraviolet exposure and reduce risk of skin cancers, according to ...Engineered stem cells can home in on tumors and deliver drug payload in mice
...ron beta, and 37 days in untreated mice. Mice with melanoma that were treated with MSC more than doubled their survival (73.5 days) compared with treated mice (32 days) and untreated mice (30 days). Andreeff says that use of interferon beta therapy in this study is less important than proof that the M...M. D. Anderson receives SPORE grant for melanoma research
... the first such grant ever awarded exclusively for melanoma research. The five-year, $11.5 million Specialize... will give a boost to the institution's integrated melanoma research activities. Jeffrey E. Lee, M.D., professor in the Department of Surgical Oncology and a su...Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors
...ndothelial cells, but not on insidious, aggressive melanoma cells that masquerade as endothelial-like cells by...were unable to prevent vascular networks formed by melanoma cells. Further experiments showed that endothelial cells have more endostatin receptors tha...SSX, a new family of cancer vaccine targets
...ous immunological reaction against cancer cells in melanoma patients, offering a new target for the development of a therapeutic melanoma vaccine. SSX-2 is the prototype of the SSX family, and is part of a larger group of proteins known a...Seal of approval scheme needed for complementary and alternative websites
...porting a six-fold increase in 5-year survival for melanoma compared to rates reported in the medical literature was too methodologically flawed to allow any firm conclusions; A review of all 10 randomised controlled trials for mistletoe an often advocated CAM found no good evidence for an effect on cancer...Jefferson researchers find immune response, dosing keys to vaccine's success against melanoma
...tates. Nearly one-half 44 percent of malignant melanoma patients enrolled in a clinical trial who received...cal and clinical results of a vaccine given to 214 melanoma patients with clinical stage III disease, meaning it had spread to lymph nodes that were large enoug...Skin photographs may help patients detect new or changed moles
...e been identified as the strongest risk factor for melanoma (a type of skin cancer), according to the article....ous. Patients have a better chance of survival if melanoma is detected early, according to the article. SSE is important because detection of changed or new m...Annals of Internal Medicine tip sheet December 16, 2003
... United States. Researchers reviewed 18 studies on melanoma and sunscreen use and found that sunscreen was not linked to melanoma risk (Article, p. 966). Some of the studies did not account for the possibility that people with a h......"Other studies have found online information about melanoma is inaccurate only 14 percent of the time and for sarcoma, only 6 percent of the time." The research points to the difficulty many patients have in finding basic information online about bladder cancer. After weeding through the broken links and site...