Some brain cells 'change channels' to fine-tune the message
... they allow in by swapping one kind of channel, or membrane opening, for another. Doing so lets the cells fine..., on the cell and trigger "channels" in the cell's membrane to open. Depending on the receptor and the channel, in will flow sodium, calcium, chloride or other ...GlaxoSmithKline receives unanimous favorable recommendation by FDA Advisory Committee for Boostrix
...and low-grade fever. As the disease progresses, a membrane can form over the airway and result in respiratory obstruction which can lead to death. Other complications may include heart failure and paralysis. Most cases of diphtheria occur among unvaccinated or inadequately vaccinated persons. Tetanus (lo......e include analysis of secretory granules and their membrane components; demonstration of a proton pump in secr...n recent years, there has been intense interest in membrane trafficking in the cell and the process whereby the fusion of secretion granules and cell membranes ...Portable system offers dialysis patients 'liberating' changes
...peritoneal dialysis, where the patient's abdominal membrane filters out waste, a process usually performed at home. The most common form of treatment is hemodialysis, which separates toxins and excess water artificially from the patient's blood. Hemodialysis usually takes place in clinics or hospitals, though...Impact of scientific advances on drug studies and membrane research to be explored
... the future of drug discovery, and research on the membrane proteins and lipids that form the drug-targeted bo...ment, to the molecular biology and genetics of the membrane processes leading to thermosensation and hearing. For a complete list of speakers, topics and the sc...Induction at 32 weeks possible action for expectant moms with premature membrane rupture
...linic study of pregnant women who experience early membrane rupture has found induction of labor at 32 weeks g...in how the babies do?" In cases of prolonged early membrane rupture, obstetricians must do a careful dance to get the unborn baby as close as possible to term, ...New way to block pox shows promise in lab study
...produced by the smallpox virus, attaches to a cell membrane receptor called erb-B1. This interaction primes the cell to become a factory for producing new virus particles. Could smallpox replication be hampered by specifically blocking the SPGF pathway? To find out, Dr. Reinherz and his team added an experim...A site for sore eyes: New target for allergies found under the eyelid
...no and colleagues discovered that within the clear membrane that coats the inner surface of the eyelid and outer surface of the eye, known as the conjunctiva, MIP-1a was essential in the initial stages of development of an allergic response. MIP-1a was also necessary for the second phase of the disease, whi...The sustained benefits of very early treatment of rheumatoid arthritis with anti-TNF-alpha therapy
...lpha therapy on synovitis, the inflammation of the membrane lining the joints, as well as bone erosions, every patient underwent magnetic resonance imaging (MRI) scans of the hand at baseline, at four weeks, and then at eight-week intervals until 54 weeks. The MRI scans were repeated a final time at 104 week...Timing appears essential to combining antiangiogenesis and radiation therapy
...mes abnormally thick in tumors, indicated that the membrane was thinner during the day-2-to-day-5 time period and also showed that this improvement resulted from the increased activity of specific enzymes. One crucial result of these findings is alleviation of the concern that reducing a tumor's blood supply ...Understanding how prostaglandin prevents gut injury during radiation therapy
...ation exposure, bax relocates to the mitochondrial membrane and trigger cell signaling events that lead to cell death. Administration of PGE2 to radiation-exposed mice was found to activate AKT phosphorylation events that block the relocation of bax within the cell, and therefore prevent cell death. The data ...Infection puts extremely low birth weight infants at risk for developmental delays
...id. As expected, meningitis--an infection of the membrane covering the brain and spinal cord--was associated with neurological impairments. For example, in the group that had meningitis with or without sepsis (an infection of the blood) 38 percent had low scores for mental development, compared to 22 perce...New protein associated with aggressiveness in breast and ovarian cancer
...re activated when a receptor on the outside of the membrane is stimulated and the signal is brought into the cell. The "best current evidence" is that Rab25 is involved in deciding whether those internalized cell surface receptors "will either be degraded or will be returned to the cell surface," he says. Bas...U. Va. researchers unravel a central mystery of how hearing happens
...y forming a channel resembling a donut in the cell membrane of inner ear hair cells. "In the absence of sound, the hole is closed, "Holt explained. "But when sound strikes the protein, the hole pops open like a trap door, allowing potassium and calcium ions to flood into the cells. Because these elements car...New way of controlling cholesterol may help treat Alzheimer's
...rols whether cholesterol is stored in the cellular membrane or in intracellular droplets, also appears to regulate the formation of amyloid-beta, the protein fragments that make up amyloid plaques. The current study was designed to test that same approach in living animals. At first, researchers tested w...Physics World Digest August 2004: Eye surgery sharpens up
...ns, who need to alter permanently this transparent membrane to ensure that light is sharply focused on the retina. The information is currently obtained by reflecting a narrow strip of light that is shone into the patient's eye. The new technique, developed by Jos Almeida, Sandra Franco and colleagues at the ...Compound in salsa may fight food poisoning
... believe the compound works by destroying the cell membrane of bacteria, similar to the way soap kills bacteria. As the compound does not appear to interfere with any of the protein-manufacturing machinery of the cell, as occurs with many commercial antibiotics, bacteria are less likely to develop resistance ...$5 million NIH contract to fund development of pediatric heart assist device
...pport is available for children via extracorporeal membrane oxygenation, or ECMO, and the Bio-Pump, but both provide support for only a few days to, at most, a few weeks. Other devices either are not available in the United States, or are adaptations of adult technology, which are not useful for very small ch...HIV: A sugar shield to evade host defences
...ion of binding the viral particle to the host-cell membrane (the CD4 of the immune system), which implies that on the env gene, the virus would manage to reconcile two opposing selection forces, one diversifying, the other conservative. The research team used statistical significance tests to identify this p...Patients with uncontrolled epilepsy have low levels of fatty acids
...group with uncontrolled epilepsy (mean erythrocyte membrane DHA level of 2.74%) when compared to DHA levels in the healthy group (epilepsy (mean erythrocyte membrane DHA level of 3.46%). This implies the brain also has low membrane levels of DHA in neuronal membrane...