Duke researchers identify the mechanisms by which drug combinations kill fungal infections
...nse that allows the cell to survive assault on the membrane by the azoles. Inhibition of calcineurin cripples this stress response and now allows the azoles to kill rather than simply maim the fungal cells," he said. The researchers at Duke, which also included Maria Elena Cardenas and John McCusker from the ...Study suggests mechanical forces drive early heart development
...t at Washington University , has discovered that a membrane that covers the tube may play a major role in caus...ightly biased to the right normally , and that the membrane pushes it the rest of the way," Taber explained.Taber says engineers are just now looking at growth ...Risk of lung damage from ultrasound greater than once thought
...his type of lung damage.The air-blood barrier the membrane through which oxygen diffuses in the lung is very... damage. One possible explanation is that the lung membrane becomes less pliable with age, and rips more easily when exposed to sound waves, OBrien said. The re......performed in a patient's home, uses the peritoneal membrane as the filter device. To gain access, a catheter ... osmosis, toxins and excess fluids move across the membrane into the solution. After a predetermined dwell period, the solution is drained from the cavity thro...Study shows infliximab can maintain long-term remissions in Crohns disease
...e by binding to and neutralizing TNF-a on the cell membrane and in the blood. In October, 1999, Infliximab was approved for marketing in combination with methotrexate for the treatment of rheumatoid arthritis in patients who have had an inadequate response to methotrexate alone. In December, 2000, the FD...O.R. model could reduce high death rate among kidney dialysis patients by up to 20%
...hrough a dialyzer - a device with a semi-permeable membrane - allowing a significant reduction in the concentration of blood toxins. On average, say the authors, Medicare reimburses centers $126 per dialysis session. Because a dialyzer costs between $30 and $70, a center typically retains a patient's dialyzer...OHSU researchers capture cell transmissions on tape for first time
...e cells as vesicles surfaced, bonded with the cell membrane and were later released....Scientists develop polymers with nitric-oxide releasing particles
...by-pass surgery, kidney dialysis or extracorporeal membrane oxygenation (ECMO). Meyerhoff also hopes to use NO-releasing polymers to coat implantable blood sensors, currently under development at U-M, which could continuously monitor vital electrolytes and blood gases in critically ill patients. "Ten-nano...Self-assembled nano-capsules resemble bacterial cell walls
...ion of nano-scale tubular capsules. "The composite membrane is organized into three layers," Wong said. "A middle lipid layer, similar to the plasma membrane that surrounds most cells, is sandwiched between two layers of actin filaments. The filaments first...Purdue 'stealth compounds' attack cancer cells
...l growth can be readily delivered through the cell membrane only in pieces that then must be assembled by the ...ially designed nucleotides that can cross the cell membrane undetected. The method works by adding another chemical component to the charged phosphate of the nu...Researchers discover alcohol-sensitive membrane channel
... Number 12, pages 1084-1090) identifies a new cell membrane channel whereethanol, the alcohol found in intoxicating beverages, may act. Neurobiologists from the Waggoner Center for Alcohol and Addiction Research and Section onNeurobiology, and the Department of Pharmacology and Toxicology, College of Pharmacy......mission in astatistical analysis include prolonged membrane rupture for more than six hoursand internal fetal ...ode of delivery and breastfeeding. If duration of membrane rupture andinvasive fetal monitoring are confirmed to be associated with perinatal HCVtransmission, ...Duke team seeks novel vaccine strategy for HIV
...ajor limitation of the SIV model is that the outer membrane of SIVis different from that of HIV, so if the goal is creating a vaccine based on asurface protein, the SIV model has limitations. So the researchers developed aSHIV animal model by combining human and monkey AIDS viruses to create a newvirus that ...Abstemious mice offer hint at molecular target for treating alcoholism
...ne neuron, itlatches onto the receptor site in the membrane of a target cell and there, likea latchkey, opens the receptor's channel, allowing chloride ions containingsignals of inhibition to flow through to a receptive neuron. The result is a flood of gratification, relaxation or sedation (depending on the s...A new ion channel involved in cell proliferation: evidence for its oncogenic potential
...e they actas voltage-dependent potassium channels: membrane proteins that regulate thepassage of potassium ions through the plasma membrane upon changes in membranepotential. Therefore, they are essential elements contributing to the electr...Use it or lose it applies to nervous system, scientists find
...ientists have monitored thecomings and goings of a membrane protein in living animals. They found that amuscle...e. "No one had previously monitoredthe turnover of membrane proteins in a single cell in a living animal,"Akaaboune says. "People tried to understand turnover b...... in asingle step, and that's exactly what this new membrane technology may be able todo." If it pans out, the ... percent of all impurities are removed by a single membrane separationstep. "That's a very, very powerful separation," Kuriyel says. "And, those resultswere ach......h as protein damage and disturbances in their cell membrane causedifferent amounts of light to be emitted. In addition to understanding howultrasound-induced bubbles can damage these bacteria, these studies may suggestthe properties of an ultrasound field most effective for acoustically purifyingwater. (3aB...Cedars-Sinai pediatrician to receive award for his contributions to international child health
...e survival rate for infants suffering from hyaline membrane disease,a respiratory distress syndrome, increased from 33 percent to 83 percent in sixyears. Survival rates following cardiac surgery also increased dramatically,even surpassing those of more developed countries, and the death rate frommeconium aspi...New research method reveals high-density information storage in the brain
...ecise the underlying modifications of the neuronal membrane can be andwhere these modifications take place. The Max Planck researchers have discoveredthat these modifications are spatially highly restricted. Thus, information canprobably be stored with very high density on the surface of neurons. During theex...