HIV's deep pocket may reveal vulnerability
...41 flipsoutwards and upwards to bury itself in the membrane of the cell to be infected,"Harrison said. "Then g...e and bringing the host cell membraneand the viral membrane together." The resulting juxtaposition of the twomembranes leads to their fusion and opens the host ...UCSF professor receives Pharmaceutical Scientist of the Year Award
...omini is internationally recognized for studies of membrane transporters, proteins which allow drugs and other substances to be absorbed and eliminated by the body. Her research group at UCSF has clarified the active processes by which the body transports drugs and important natural compounds. The group was t...Why prostate cancer homes to bone
...extract areseparated from one another by a special membrane consisting of a filtercontaining pores that are ba...ugh. As an additional impediment, the side of the membrane facingthe cancer cells was coated with Matrigel--a material made from the "matrix"molecules that for...New anti-angiogenic proteins discovered
...s, the cornea pocket model and the chorioallontoic membrane model. The ability of METH-1 and METH-2 to inhibit new blood vessel formation in thecornea pocket model was compared to that of both endostatin and thrombospondin,two other human proteins. The study showed that METH-1 was most potent ininhibiting b...Jefferson scientist begins clinical trial to study promising Parkinson's disease drug
...a naturally occurring substance in the nervecell's membrane that plays an important role in cell growth, development, andrepair - to standard Parkinson's disease treatments, which improve symptoms butdo not alter the disease process. "We hope that we will be able to do something no one else has doneb...Self-assembly of new microstructured material defies textbook physics
...elson, PhD, a professor of physics at Penn. The membrane portion of the material is essentially a thin, pos...es assembles. In manycases, the positively charged membrane attracted only a few dozen negativelycharged spheres, then repelled all others. "At this point there......tremities) Auditory and ocular injuries -Tympanic membrane ruptured (typical) -Deafness/Tinnitus/Vertigo -Transient blindness/Photophobia-Conjunctivitis - Corneal damage -Retinal abnormalities (macular hole) - optic neuritis -Cataract "Lightning injuries are varied and take many different forms. The most dan...Sniffing Out The Promise Of Anti-Angiogenesis Therapy
...administrationpossible. "It can get over the nasal membrane intact," says Gill, so that morethan 70 percent of...nd hiscolleagues found that when chicken allantoic membrane was exposed to IM862 (thevessel-rich embryonic membrane is a standard tool for testing anti-angiogen...Neurobiologists Show How The Brain Processes Signals From Pheromones
...embrane receptors, meaningthat they cross the cell membrane seven times. These receptors receiveinformation from the environment outside the cell and transmit it inside thecell for processing. Now that Mombaerts has shown that the wiring diagrams of the two olfactorysystems are different, the question is why?...UF Researcher Explores Complex Relationship Between Smoking And Fertility
... Inendometriosis, tissue that resembles the mucous membrane that lines theuterus grows in the wrong place, such as in the fallopian tubes, sometimescausing abnormal bleeding and scarring, and interfering with fertility. Shiverick found that a toxin in cigarette smoke, benzo(a)pyrene,actuallyinhibited...AAPS Sponsors Second Frontier Symposium
...y, genetics/genomics, and pharmaceuticalaspects of membrane transporters, and determine the role of transporters in drugdiscovery, development and therapy. For more information on this event, including a Preliminary Program, Call forPapers and registration fees, contact the AAPS office at 703-548-3000 or visi...Researchers Splice Severed Spinal Cords
... repairing a garden hose -- the rubber is the cell membrane andthe water inside is the salty material, called cytoplasm, found inside allcells. "If we cut the hose and just hold the two ends tightly together, they'renot going to reconnect or function as a hose. But if we add this specialmolecule, PEG, the 'ru...Neurotransmission Machinery Visualized For The First Time
...neuron's extensions (axons), where theydock at the membrane and await an electrochemical signal to merge. At t... electrical and chemical forces that could promote membrane fusion.In addition, highly flexible helical structures in the complex, prone totwisting and bending,...Magnetic Hearing Aid Could Open New "Window" For Hearing Impaired
...t attached to the inner ear's round window, a thin membrane atone end of the cochlea. About as large as a pencil point, the tiny magnet would send vibrations throughthe cochlea, the fluid-filled organ shaped like a snail shell, and stimulate itsthousands of hair cells used in normal hearing. The new device i...Earliest Warning Sign Indicates Need To Test For Condition Associated With Fetal Deaths
... is associated with premature rupture of the fetal membrane and premature delivery. Both are independent risk factors for fetal death. Gugino and colleagues reviewed the records of 804 perinatal deaths that occurred in Children's Hospital of Buffalo, a regional perinatal center, between 1988 and 1996. C...Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis
... proteins that are highly concentrated within the membrane segment underlying the presynaptic nerve terminal, the postsynaptic membrane proper. By culturing embryonic spinal cord neurons and pharmacological approaches Joach...Fertilization Protein Structure To AID in Leukemia Treatment
...and this effect can be transmitted across the cell membrane by the attached tail," explains Kamal Shukla, program director in NSF's division of molecular and cellular biosciences, which funded Stout's research. The Scripps researchers hope that drugs targeted toward the cavity in CD38 could be used to...