Tag: "metastatic" at medical news

Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo

...approved use of Herceptin in 1998 for treatment of metastatic breast cancer in combination with chemotherapy. The long term outcome of such treatment, however, has not yet been established, according to Buzdar, and several large and lengthy clinical trials are now under way to test for cancer recurrence and sur...

Targeting mutant B-Raf protein reduces melanoma development

...ese discoveries are important for the treatment of metastatic melanoma since therapeutically inhibiting mutant B...tumors and more importantly prevent development of metastatic tumors at secondary sites." The study shows that in existing melanoma tumors, inhibiting V599EB-Raf ...

Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression

...mune cells with the ability to specifically target metastatic prostate cancer in mice without causing the toxic immune suppression that has been associated with earlier forms of cancer gene therapy. Chung Lee, John T. Grayhack, M.D., Professor of Urology at Northwestern University Feinberg School of Medicine, ...

New treatment options for some difficult cancers improve survival and quality of life

... use of IPHC and surgery in the treatment of other metastatic cancers of the abdomen....

Cryoablation is effective in treating cancer patients' pain

...at how well cryoablation can locally control large metastatic tumors unsuccessfully controlled with traditionaltherapies," he said....

US FDA grants full approval to DOXIL(R) following submission of phase III data

...approval, DOXIL was indicated for the treatment of metastatic ovarian cancer in patients with disease that was refractory to both paclitaxel- and platinum-based chemotherapy regimens. This approval was based on tumor response rates from three Phase II studies. According to the terms of the accelerated approva...

Stat5 protein inhibits spread of breast cancer cells

...breast cancer cells that leads to the formation of metastatic cancer, the most advanced and serious form of the disease," said Hallgeir Rui, MD, PhD, associate professor of oncology, Lombardi Comprehensive Cancer Center at Georgetown University and principal investigator of the study. The research, which was fu...

Cancer vaccines: A two-pronged attack?

.... But it seems that, in about 10% of patients with metastatic melanoma, the vaccine might actually be reawakenin...vation of CTLs. "We believe that these CTLs in the metastatic lesions could potentially eliminate the bulk of the tumor," says Dr. Boon. "Now we have to elucidate...

USC/Norris oncologists test new front-line therapy for pancreatic cancer

...s study, researchers will recruit 90 patients with metastatic pancreatic carcinoma. Half of the patients will ta...ancer, and a phase I/II trial for the treatment of metastatic melanoma....

Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy

...portunities to develop therapies for patients with metastatic melanoma," Robertson said. "Ultimately, therapies targeted against Akt3 could be used with traditional chemotherapy to give those with melanoma more effective therapeutic options to fight the disease." This research was supported by the American Canc...

Herpes virus offers new hope in curing cancer

... the herpes simplex virus is effective in treating metastatic disease in adult cancers, so we are hopeful it will be effective in treating children," he said. "It has been difficult so far to obtain enough funding to conduct such studies in children." This study was supported in part by the Cincinnati Children'...

New biopsy technique helps assess breast cancer's spread

...an use ultrasound to stage the axilla and identify metastatic disease, we can save some women the additional surgery," says Alexis Nees, M.D., clinical assistant professor of Radiology at the U-M Medical School. Nees will present the results at the RSNA meeting. The technique uses ultrasound to identify the axi...

Paclitaxel chemotherapy for breast cancer not associated with serious radiation pneumonitis

...el, has led to improved outcomes for patients with metastatic breast cancer and for patients whose disease has spread to the lymph nodes. Radiation therapy is also an important adjuvant treatment to prevent local recurrence of breast cancer, but some of the radiation focused on the breast tissue and chest wall ...

U.Va. Health System adds new cancer treatment center

...o perform Stereotactic Radiotherapy (SRT) to treat metastatic cancer in new ways. He will build on U.Va.'s long tradition of integrating the latest in radiation oncology technology into the treatment of patients with malignant disease....

Early disclosure: Post-operative radiotherapy improves progression-free survival in prostate cancer

... participants had no lymph node involvement and no metastatic disease but all displayed high risk factors for local disease recurrence (e.g. capsule perforation, positive margins or involvement of seminal vesicles). The trial ran from 1992 - 2001 and, following review by an independent data monitoring committee...

M. D. Anderson receives SPORE grant for melanoma research

...n five years. To date, therapies approved to treat metastatic disease have all been biologic, also known as immunotherapies. Still, we are only seeing survival past five years in less than 10 percent of patients. These therapies are offering a hint, but it's not the answer," says Grimm, who has been studying me...

Twice daily imatinib could improve outcome for people with specific form of gastro-intestinal cancer

...nal Trials Group (AGITG) studied 946 patients with metastatic GIST who were randomly allocated either imatinib 4...e sufficient. However, in patients with widespread metastatic disease, the prolonged progression-free survival achieved with 400 mg twice daily might lead one to ...

'Hedgehog' signal distinguishes lethal from localized prostate cancers

...ve discovered a possible way to distinguish lethal metastatic prostate cancers from those restricted to the waln... signaling pathway. In contrast, all 15 samples of metastatic prostate cancers, donated at patients' deaths, had Hedgehog activity, which was 10 to 100 times high...

Cancer burden seen even many years after diagnosis

...e shorter survival times being more likely to have metastatic or, at least, active cancer. "[C]ancer survivors had poorer health outcomes than did similar individuals without cancer, across burden measures. The decrements were consistent in individuals with different tumors and in individuals across multiple pe...

Two landmark studies show Taxotere (R) significantly improves survival in men with prostate cancer

...tment of androgen-independent (hormone-refractory) metastatic prostate cancer have been presented at the plenary...nefit in androgen-independent (hormone-refractory) metastatic prostate cancer patients, giving hope to thousands of men worldwide," said Daniel Petrylak, MD, Asso...

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