Tag: "methotrexate" at medical news
Clinical trial of Etanercept for Wegener's disease shows no benefit
...lucocorticoids (prednisone), cyclophosphamide, and methotrexate
leads to mounting morbidity from treatments. At the same time, each disease flare has the potential to cause irreversible damage. Wegener's granulomatosis frequently leads to kidney failure, hearing loss, damage to the respiratory tract, peripheral...
The sustained benefits of very early treatment of rheumatoid arthritis with anti-TNF-alpha therapy
...findings, patients taking infliximab combined with methotrexate
showed a significant reduction in levels of synovi...ared with 2 out of 10 patients in the placebo plus methotrexate
group. One year after withdrawing from anti-TNF-alpha therapy, the patients in ...
Combination drug therapy could substantially improve symptoms of rheumatoid arthritis
...ects around 1% of people worldwide. Etanercept and methotrexate
are known to be effective in the treatment of rheu...ercept (25 mg subcutaneously twice a week) or oral methotrexate
(up to 20 mg every week), or combination of both treatments. Clinical response was assessed by crite...
Newer rheumatoid arthritis drugs: Harmful on the liver?
...d included leflunomide, the newer biologic DMARDs, methotrexate
and other traditional DMARDs. Their study shows that the risk of serious hepatic events was significantly increased only with biological modifier DMARDs, not with leflunomide or other DMARDs. "Evaluative studies such as these are extremely important ...
Standard treatment for rare form of deafness no more effective than placebo
...n patients who regain some hearing after steriods, methotrexate
has been prescribed over the long term with the go...ing. "The question we wanted to answer was whether methotrexate
can effectively be substituted for long-term steroid use, which isn't feasible because of potential ...
British scientists receive Lasker Prize for discovering new treatment for rheumatoid arthritis
...ome, especially if immunosuppressive drugs such as methotrexate
are used in conjunction with it. For this work, Feldmann and Maini have also been honoured by the award of the Crafoord Prize of the Royal Swedish Academy of Science in 2000. Sir Ravinder comments: "The discovery that inhibiting just one molecule cou...
Newly approved psoriasis drug invented and tested at Univ. of Michigan
...is suspects. Cyclosporine can be toxic to kidneys, methotrexate
can harm the liver, and UV therapy can increase the risk of skin cancer....
Annals of Internal Medicine, tip sheet, November 5, 2002
...se pain, and functioned better than those who took methotrexate
and a placebo or dummy pill (Article, p. 726). Abo...s were more common with combined therapy than with methotrexate
alone. The authors caution that patients should receive careful monitoring for drug-related liver da...
Survival benefit for rheumatoid arthritis patients treated with methotrexate
The anticancer drug methotrexate
could have a substantial survival benefit among pa...ovascular disease, infection, and cancer. Low-dose methotrexate
is the main choice of antirheumatic therapy for rheumatoid arthritis, although its effect on mortali...
Study shows infliximab can maintain long-term remissions in Crohns disease
...mab was approved for marketing in combination with methotrexate
for the treatment of rheumatoid arthritis in patients who have had an inadequate response to methotrexate
alone. In December, 2000, the FDA expanded the indication to include inhibiting the progression of ...
Behavioral program boosts antibody that fights breast cancer
...f somechemotherapy drugs -- methotrexate
and 5-FU -- than did otherpatients. Although women in both groups were initially prescribed similar doses of chemotherapy drugs, Andersen said women who didn't receive the interven...
ENBREL application for early, active rheumatoid arthritis filed with the U.S. Food and Drug Administration
... placebo twice aweek by subcutaneous injection and methotrexate
or placebo once a week in pillform to ensure appropriate blinding of the trial. The two primary endpoints studied were the ability of ENBREL to: 1) Slow the progression of RA as measured by digitized x-rays to monitor changesin joints. 2) Reduce s...
Positive Results Of Pivotal Phase III Trial With ENBREL In Patients With Early, Active Rheumatoid Arthritis
...either 25 mg or 10 mg of ENBREL, or up to 20 mg of methotrexate
for 12months. Patients received both ENBREL or placebo twice a week by subcutaneousinjection and methotrexate
or placebo once a week in pill form to ensureappropriate blinding of the trial. The most c...
Changing Drug Delivery For Rheumatoid Arthritis Patients Increases Effectiveness, Lowers Costs
... months and then switched andstarted receiving the methotrexate
for at least three months by injection. Partially because of side effects, such as nausea, 31 percent chose toswitch the way they receive their medication. After the change from an oral doseto an injection, only 4 percent still complained of ...