2005 Basic Research in Periodontal Disease Award
...or Curtis' research group is focused in two areas: microbial protease function and the mechanism and role of glycosylation of bacterial virulence determinants. Bacterial protease research concentrates on characterization of the structure and genetics of proteolytic enzymes of the periodontal pathogen, Porphyro...Infectious agent linked to mad cow disease found in organs other than the brain
...ssed in animals suffering from inflammation due to microbial infection or autoimmune disease," said Nancy H. Ruddle, the John Rodman Paul Professor and Director of Graduate Studies in the Department of Epidemiology and Public Health at the Yale School of Medicine. Previous research in Adriano Aguzzi's group at...Gene vaccine protects mice against development of Her2/neu breast cancer
...said. "This vaccine, however, like many that treat microbial infections, appears to create a memory in the immune system that produces a lasting protective response." The vaccine used in this study is a "viral-vectored" approach, in which a naturally occurring virus is re-engineered to be propagation defective...Global air pollution map produced by Envisat's SCIAMACHY
...ir also creates nitrogen oxides naturally, as does microbial activity in the soil. Localised in-situ measurements of atmospheric nitrogen dioxide are carried out in many western industrial countries, but ground-based data sources are generally thin on the ground. Space-based sensors are the only way to carry...Large families and animals keep allergies at bay
... authors. These findings support the importance of microbial exposure for preventing atopic dermatitis, but challenge the hypothesis that infectious diseases in infancy protect against its development, they conclude....Poor diet and physical inactivity may soon overtake tobacco as leading cause of death in U.S.
...; 3.5 percent). Other actual causes of death were microbial agents (i.e., influenza and pneumonia, 75,000), toxic agents (exposure to pollutants, asbestos, etc., 55,000), motor vehicle crashes (43,000), incidents involving firearms (29,000), sexual behaviors (20,000), and illicit use of drugs (17,000). "The r...Zengen's new study reviews novel approach to control inflammation using melanocortin receptors
...nlike corticosteroids, melanocortins do not reduce microbial killing activity, but enhance it. We are encouraged by these findings and will continue our research and development efforts in peptide technology." Zengen's researchers also conducted a separate study on melanocortin receptors that was published i...Utah researchers hope hunt for medicinal drugs helps save Papua New Guinea rainforests
...inea. Wyeth Research will contribute with a strong microbial discovery and drug development program. Part of the grant, $100,000, has been used to build a pharmacology laboratory at the University of Papua New Guinea. As compounds are discovered from plants, a cottage industry may be jump-started. Barro...Probiotics beneficial even when inactive, according to UCSD study
...hat are known to respond to a variety of signature microbial molecules. In order to determine which TLR responded to probiotics, the team administered a chemical called chloroquine to mice deficient with several different TLRs. Chloroquine had recently been demonstrated to inhibit TLR9 activation, and it was...Combination drug therapy offers hope for malaria treatment
... as other malarial drugs have been associated with microbial resistance. A meta-analysis by the International Artemisinin Study Group of 16 randomised trials (12 from sub-Saharan Africa, three from Thailand, one from Peru) shows that artesunate was highly effective in treating malaria when added to other an...SARS outbreak in Beijing spread rapidly, was controlled fairly quickly
...s well in responding to a recurrence and to future microbial threats, whether naturally occurring (e.g., the next influenza pandemic) or the result of a terrorist attack," Dr. Hughes concludes....Purefecta (TM) drinking water purifier from Pall and Kinetico removes pathogens...
..."When healthy people drink water contaminated with microbial pathogens, it could cause diarrhea. However, for a...not ensure that drinking water is entirely free of microbial pathogens. Outbreaks of waterborne disease occur primarily due to the use of untreated or inadequate...Novel delivery system devised for toxoplasmosis treatment
...nked to triclosan, could cross multiple animal and microbial membranes to enter the host cell, pass through its internal barriers, enter cysts, which consist of densely packed animal and parasite constituents, enter the parasite, cross into the specialized organelles within, then release the triclosan, which i......ky? Raisins are high in sugar, which inhibits microbial growth associated with spoiled food and food borne illness, explained Daeschel. "The sugar makes the water in food less available to microbes." And raisins are acidic, which also discourages microbes. With a grant from the California Raisin Board,...American Chemical Society plans national meeting in New Orleans March 23-27
...s of pigments in red wine Food safety challenges: microbial and chemical toxins The use of electrical fields to clean up contaminated soils, sediments and groundwater New techniques to strengthen homeland security A look at the Gulf Coast environment New treatments for diabetes, atherosclerosis and obesit...NIAID releases 20th anniversary edition of Jordan Report on vaccine research
...gical advances such as recombinant DNA technology, microbial genome sequencing and the ability to synthesize organic molecules have created opportunities to identify new vaccine candidates, to improve the safety and efficacy of existing vaccines and to design new vaccine strategies. The 300-page Jordan Report ...The Lancet Infectious Diseases (TLID)
...pect to clinical presentation, laboratory results, microbial epidemiology, treatment, and infection control. Moreover, ageing may be the cause of infection but infection can also be the cause of ageing. In a related commentary, Kevin High (Wake Forest University School of Medicine, Winston Salem, NC, USA)looks...Genetic variant reduces immune response, yet protects against atherosclerosis
...n the body's immune response to bacteria and other microbial toxins and to provide some protection against atherosclerosis, or clogging of the arteries. The scientists believe their discovery suggests a possible new approach to anti-atherosclerosis drugs. The genetic variant, or polymorphism, occurs in one of ...Think youre healthy? Open wide and look inside
...s well as a number of systemic diseases, including microbial infections, immune disorders, injuries and some cancers. The case report published in the Journal of Periodontology describes how excessive swollen gums, fatigue and weight loss experienced by a 53 year-old man lead to the diagnosis of acute myelomo......dy where immune cells are activated in response to microbial invaders or other signals. According to Dr. Germain, the new technique will permit investigators to explore questions they previously could not clearly address: for example, how long do T cells remain in contact with their target cells, when do the...