Tag: "modulates" at medical news

UCSF study offers insight into human circadian rhythms

... of the paper. "As the enzyme produced by the gene modulates many proteins, we may test for its impact on novelty seeking and learning and memory, too." "The discovery of the gene opens the window just a crack, but it could let in a lot of light for probing the neurobiology of the brain," says co-senior author...

Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find

... response. "In the paper, we showed that uric acid modulates peroxynitrite's effects," Dr. Hooper says. "It's incredibly useful in preventing the damage related to peroxynitrite as a toxic molecule. More importantly, it stops the secondary injury cascade by preventing the neutrophils from getting into spinal c...

New math model of heart cell has novel calcium pathway

...ay that influences calcium cycling in the cell and modulates many processes involving calcium, including activities of calcium channels" said Rudy. "Having this pathway modeled is a valuable research tool because there is a strong link between abnormalities of calcium handling and cardiac arrhythmias. In addit...

Brain region identified that controls collecting behavior

...arly there is some higher structure in humans that modulates the collecting drive and that's what we think we have tapped into." The UI team studied 86 people with focal brain lesions - very specific areas of brain damage to see if damage to particular brain regions could account for abnormal collecting behav...

Multi-center study finds therapy boosts kidney transplants in 'highly sensitized' patients

...Los Angeles. "The good thing about IVIG is that it modulates the immune system, it doesn't suppress it. It appears to 'turn off' deleterious immune responses without damaging the immune system, and in fact, it strengthens the immune system because it provides antibodies to infectious agents as well." Although ...

How brain gives special resonance to emotional memories

...rting the notion that the brain's emotional region modulates activity in the memory regions to form an emotional memory," said Dolcos. "This idea was supported by animal research, but the evidence from neurologically intact humans was scarce and indirect. So, our goal was to find the right method that would al...

NIH launches study of hematopoietic stem cell transplantation for severe, treatment-resistant lupus

...that both diseases can benefit from treatment that modulates the immune system." In addition to the clinical study, researchers will look at how B and T cells function in the immune systems of lupus patients. Previous studies have shown that the dysfunctioning T cells, which normally regulate the immune respon...

Increasing the risk of cancer

... A selective COX-2 inhibitor differentially modulates tumor angiogenesis and growth in COX-2 expressing and COX-2 lacking pancreatic cancer in vivo: Abstract No. 4792 A popular drug used to treat arthritis worldwide has been found to promote tumor growth in specific types of...

Optical glucose sensor holds promise for diabetics and intensive care patients

...garam said. In Singaram's sensing system, glucose modulates the fluorescent signal by binding reversibly to a boronic acid component attached to the quencher molecule. Singaram's team designed the fluorescent dye (an anionic pyranine sulfonamide monomer) and the quencher (benzyl viologen with a boronic acid f...

Zengen's new study reviews novel approach to control inflammation using melanocortin receptors

...sn't abolish the inflammatory response but instead modulates it. An advantage of melanocortins in the treatment of inflammation is that their influences are broad and are not restricted to a specific mediator or chemical pathway." Recognition and cloning of five melanocortin receptors has greatly improved u...

Other highlights in the August 6 issue of JNCI

...lymorphism of the beta-3 integrin, Leu33Pro, which modulates the function of the integrin, influences cancer risk among the general population in Denmark. Although only 2.7% of the population was homozygous for the polymorphism, the authors found that the cumulative cancer incidence and the age-adjusted relati...

JCI table of contents, 1 August 2003

...ergy balance. A complex combination of mechanisms modulates our desire to eat and the ability to efficiently u...ve pathway by which the enzyme hepatic lipase (HL) modulates the risk of developing atherosclerosis, the condition where blood vessels narrow and harden due to h...

Chemical turns stem cells into neurons say scientists at Scripps Research Institute

...er of physiological signaling processes whereby it modulates other enzymes by attaching a phosphate group to th... stem cell into a neuron. And the fact that TWS119 modulates the activity of GSK-3beta suggests that TWS119 is likely to provide new insights into the molecular ...

American Thoracic Society Journal news tips for November (second issue)

...egions as the left frontal cortex, in an area that modulates upper airway motor function, and the cerebellum, which is a brain structure that plays a major role in cardiovascular and respiratory control. The researchers said that a portion of the volume changes may have been present before the onset of OSA an...

Blocking enzyme found to ease anxiety without causing sedation

...neurosteroids, and thereby decreases anxiety. "PKC modulates the modulator," Messing said. Because it is an intermediary, it is a promising focus for drugs that could decouple the biochemical pathway that leads to anxiety from the pathway that leads to sedation, he said. The researchers focused on physiologica...

Bleach-producing enzyme found to modulate blood vessel dilation during inflammation

...e of myeloperoxidase. "Identifying a protein that modulates nitric oxide-dependent blood vessel dilation has important implications for the potential treatment of inflammatory vascular diseases," said Eiserich. "Under acute inflammatory conditions, such as intense bacterial infection, this enzyme may provide ...

Outsmarting cancer - new results from novel enzyme inhibitors

... smart drugs. Proteasome is a protein complex that modulates the behaviour of cells during the cell cycle. It regulates the levels of key proteins that control the fine balance between normal cell division and normal programmed cell death. In cancer cells normal programmed cell death goes wrong and the cancer ...

Common pathway found in early stages of addiction to alcohol and many drugs

...e said, would be to find a molecule that blocks or modulates access to the key brain receptors without blocking the receptor's normal function, crucial to learning. The study is published in the March issue of the journal Alcoholism: Clinical & Experimental Research. It was carried out by Camarini and coll...

MCG researchers find clues in process that enables working memory

... "This protein may help us understand how dopamine modulates working memory," Dr. Bergson said. They have found that calcyon directly interacts with dopamine D1 receptors and, in the presence of dopamine, the receptor activates two types of signals, known as second messengers. The researchers' next step is to...

Scientists identify new pathway of antidepressant action

...ne, a steroid made in the brain, which most likely modulates mood and plays a role in heightened anxiety and depression found in severe premenstrual disorders and other conditions," said Synthia Mellon, PhD, senior author on the PNAS study and a professor of reproductive endocrinology at UCSF. "The study poin...

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