UCSF finding could lead to a new class of painkillers
... drugs. Finally, the researchers showed that PKC modulates the pain response induced by the chemical known as nerve growth factor. When the factor was injected into normal rats exposed to stimulation, the animals experienced heightened pain. But when the factor was injected in animals in which PKC was inhibi...Sniffing Out The Promise Of Anti-Angiogenesis Therapy
... cells." Itinhibits blood vessel formation and/or modulates the immune system. KS is treatable (though not curable) with conventional chemotherapy, but, notesGill, "chemotherapy comes along with so much toxicity that people will only stayon it for a period of time before they literally get sick of it." IM862,......ood thing about IVgammaglobulin therapy is that it modulates the immune system, it doesn'tsuppress it, and it doesn't predispose the patient to infectious complications.We think that it is able to "turn off" deleterious immune responses withoutdamaging the immune system. In fact, we believe it strengthens the ......rmine the physiologicalmechanism by which orphanin modulates the circadian cycle. "Understanding thatthe system exists is the first step," said Grandy. "From that point we canbetter understand how it works. The ultimate hope is that these discoveries leadto better treatments for sleep disorders." The O...UCSF Study In Rats Suggests Synthetic Drug Mimicking Marijuana Might Be Used To Treat Pain
...own as therostral ventromedial medulla (RVM) which modulates pain by either increasing ordecreasing the amount of pain signals that pass through the spinal cord. Theytested the effects of the synthetic cannabinoid, WIN555, 212-2, on this regionby measuring the time it took for rats to move their tails away fr...