Tag: "molecule" at medical news

Fertilization Protein Structure To AID in Leukemia Treatment

...early stages of their development. Because a CD38 molecule has a remarkable similarity to the cyclase protein, Stout and his collaborators think that CD38 molecules also pair up to create an internal cavity. However, unlike cyclase, CD38 has a tail reaching across the cell membrane, providing a means for i...

Duke Study Uses Tiny Temperature Changes To Probe Water-Exclusion At Protein Binding Sites

... reporting that the waythe atoms are arranged in a molecule plays a crucial role in determininghow important water reorganization is to ligand binding. If removing water from the binding site were not important, he reasoned,then the net temperature changes should be the same regardless of whetherthe rea...

Mother's Milk: Nutrition And Nurture For Infants -- And The Best Defense Against Disease

...ach to andthen attack cells in the infant. Another molecule with an antibacterial role islactoferrin, a protein that acts by binding iron in different situations. Insome circumstances, lactoferrin is also able to act as a cytokine. Formula-fed babies are denied many of the immune and other benefits th...

Affordable, Hand-Held Biosensor For Diagnostics

...ons that involve the recognition andbinding of one molecule to another partner molecule. In their tests, for example, the biosensor was able to match tinyconcentrations of specific DNA sequences to its complementary strand, suggestinga potential role for a variety of genetic studies and tests, includi...

Tighter Chemical Binding = Better Meds

...t (203) 432-6278. A color slide of an FKBP protein molecule binding with a drug thatstimulates nerve growth is available from the Yale Office of PublicAffairs upon request. The computer-generated image was produced by X-raycrystallography. Call (203) 432-1326....

BioNumerik Reports Preclinical Antitumor Data On Two Novel Supercomputer Engineered Anticancer Agents At 89th Annual AACR Conference

... rapid discovery and clinical development of small molecule basedpharmaceuticals for cancer. BioNumerik is a leader in a powerful new areacalled "mechanism based drug discovery" which integrates medicine, quantumphysics, synthetic chemistry, pharmaceutical sciences and Cray supercomputing. BioNumerik views i...

New Research In Battling Alzheimer's Impact On Memory

...eterminations, the Canadian group has found a lead molecule thatlooks very promising. It "can mop it all up," says Weaver. He cautions,however, that any human application is at least two years away. Paper MEDI 214 will be presented by Donald F. Weaver from 4:55 to 5:30 p.m.,Thurs., April 2, in the Conventi...

Researchers Identify Candidate Immunosuppressant With Fewer Side Effects

...rchmade a peptide that binds to calcineurin, a key molecule in the pathway thattransmits signals from the T cell receptor to the nucleus. The key differencebetween how the peptide and the drugs cyclosporin A and FK506 work is the regionon calcineurin where each of these agents bind. Cyclosporin A and FK506 bl...

Chemical Society's Highest Award Goes To Ronald Breslow

...and then harvest the corticosteroids. "Our molecule mimics the function, but not the structure, of enzymeproteins," said Breslow. Where proteins are difficult to make and sensitive toheat or other reactions, the chemist's "artificial enzyme" is simple,economical, and durable. The Priestley Med...

Identification Of Brain Areas Could Help Eliminate Side Effects Of Pain Medication

... specifically targeted an area in the brain and a molecule that causes side effects from pain medication. We...de effects of pain medication by building another molecule to tag onto the opioid molecule. This way the opioid could block the pain, and this new molecule co...

Crystal Structure Of gp120 Reveals HIV In Action

...omplements and extends the fuzziersnapshots of the molecule from genetic studies. "We can use mutational analysisto say 'the CD4 binding site must be here.' But with X-ray crystallography, weactually see it," explains Dr. Hendrickson. And what they see in the structureis what the immune system doesn't. "We di...

Study Reveals Possible Clue For Racial Differences In Prevalence Of High Blood Pressure

...ide is reduced," Panza says. Nitric oxide, a small molecule released by a lining of cells on the inner wallsof blood vessels, "signals" the vessels to dilate and increase blood flow toskeletal muscles, such as those in the arms or legs, when they may be needed torespond to a stressful situation. The finding m...

Tiny Pellets Could Deliver Alzheimer's Drugs

...ped one solution by coating the surface of the NGF molecule with a water-soluble polymer called polyethylenegl...needle or catheter. Belcheva has modified the NGF molecule chemically so that it will bind with the polymer. The microspheres have not yet been tested in rat b...

Unsticking The "Glue" In Blood Cells Could Save Lives

... which iscritical to controlling blood loss. But a molecule called glycoprotein IIb IIIa usually allowsplatelets to stick to one another. "So what the drug companies want to do,"Konstantopoulosexplains, "is to block the receptor for IIb IIIa, without affecting Ib. Thatway, you can reduce therisk of clots whil...

Study Shows Potential For Quelling AIDS Nerve Pain

...), found naturally in the body, is a small, potent molecule that helpsmaintain certain nerve cells. It also prods those nerve cells to grow and to communicate with other cells. In the study, presented at this year's International AIDS Conference inGeneva, the patients got injections of either a moder...

University Of Florida Researchers Hope To Ease Asthma Pains And Provide A Sigh Of Relief

...e lungs of asthma sufferers. "When our drug molecule sticks to the receptor, it is likely that thereceptor changes shape," Richards said. "This change in molecular shapetriggers a series of chemical processes in the lung cell that ultimatelylead to the walls of the airways relaxing so that a larger vol...

New Drug Boosts The Power Of Traditional Cancer Therapies, UF Animal Studies Show

...andard treatments. Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum, was identified a decade ago by George R. Pettit and his colleagues at Arizona State University. In collaboration with the National Cancer Institute and the Gray Laboratory in the Un...

Substance Discovered That Induces Hair Follicle Formation In The Mature Skin Cells Of Mice

... in the November 25 issue of Cell, indicate that a molecule called beta-catenin may be the long sought message...nin appears to have another role: it reacts with a molecule called LEF-1, which is expressed only in cells that will eventually become hair follicles. Together...

Signal Pharmaceuticals Announces Positive Results In Preclinical Study Of Novel Drug Leads For Treatment Of Osteoporosis

...lashes. Signal is developing new classes of small molecule drugs that potently andselectively control the mec...companyfocused on identifying new classes of small molecule drugs that regulate genesand the production of disease-causing proteins. The Company applies advanc...

New approach supercharges immunotherapy

...receptor for antigen, known as CD3, a cell-surface molecule thatrecognizes foreign tissue. Nearly ten years ago, however, Chicago researchers Craig Thompson and JeffreyBluestone and others discovered that the immune system often requires twoparallel lines of communication -- through both CD3 and a second rece...

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