New study in 'Nature' demonstrates protection against cell death during heart attack
... says Dr. Molkentin. "Although our study was in a mouse model and looked at the heart, studies in cell culture indicate similar benefits when blood flow causes injury to the brain, kidney and liver. The data support clinical trials. Cyclosporin already has been tested in humans and has been well-tolerat...UCSF study offers insight into human circadian rhythms
...udy that has gone from the human to the fly to the mouse in a single study. It demonstrates of the combined... a relative degree. The creation of the transgenic mouse model provides a tool for exploring how the CK1 delta-T44A enzyme causes FASPS. It also offers a mod...Mouse model reveals potential way to reduce cardiac deaths in kidney patients
...oved. For the new study, researchers worked with a mouse model of metabolic syndrome, a condition common among patients with chronic kidney disease that includes symptoms such as obesity, high blood pressure and insulin resistance. The condition, which is rapidly increasing in both adults and children, is ...A marker for new blood vessel formation in tumors
...metastasize. Haubner and colleagues' work, in a mouse with human melanoma and in a small study of patients with tumors including melanoma, suggests that the marker is truly reflecting the in vivo level of the integrin. Hence the marker could be used to identify tumors that express this marker, assess th...Indiana University researchers closer to helping hearing-impaired using stem cells
...s, Dr. Hashino and her colleagues first cultivated mouse marrow stromal cells with chemicals known to encourage stems cells to change into primitive neurons. The bone marrow cells took the shape and other characteristics of neurons. Next, they exposed the cells to two molecules that are secreted from nearb...First mouse model for multiple system atrophy points to new treatment targets for brain diseases
...'s disease and amyotrophic lateral sclerosis (ALS) mouse models. Lee and colleagues report their findings in the March 24, 2005 issue of Neuron. MSA is so named because it affects multiple parts of the nervous system. Initially MSA was given three names, based on the symptoms physicians had observed. Howev...News tips from the Journal of Neuroscience
...DHA has a direct effect on amyloid production in a mouse model of AD. The studies support a role for DHA in reducing amyloid burden even at a relatively late stage in this animal model. Pass the fish oil, please....Targeting mutant B-Raf protein reduces melanoma development
...t, reducing B-Raf activity in existing tumors in a mouse model did not shrink the tumors but did prevent them from getting bigger. These discoveries are important for the treatment of metastatic melanoma since therapeutically inhibiting mutant B-Raf could prevent growth of existing tumors and more importan...Protein that helps skin cancer spread identified by Stanford researchers
...hose cells formed skin cancers that would kill the mouse if left unchecked. But when the group treated the ...e," Khavari said. If they'd found these results in mouse cells, the group would still need to prove that the fragment is relevant for humans. By studying hum...Earlier use of prostate cancer vaccines urged by Hopkins scientists
... multiplied three times as much in prostate cancer mouse models that were given vaccinations immediately after hormone therapy as opposed to those not receiving hormone therapy. "It's not immunological magic," Drake notes. "It makes sense that when hormone therapy gets rid of cancer cells and the protein...St. John's wort amplifies effect of blood thinner Plavix
... that current studies are underway in a transgenic mouse model to determine the pharmacogenetic mechanism of this observed enhanced effect of clopidogrel by St. John's wort. In the meantime, Bates echoes Lau's note of warning to patients. "Too often, people don't realize that the herbal remedies and dieta...UCSD-Utah team develops mouse model to test therapies for macular degeneration
...dicine and the University of Utah have developed a mouse model of Age-Related Macular Degeneration (AMD), t...ease that affects children and young adults. The mouse model*, which was reported in the March 4, 2005 online edition of the Proceedings of the National Ac...Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
.... He was instrumental in the development of a key mouse model of SMA, which is essential to genetic studie...ug development process by providing open access to mouse models of SMA and has been instrumental in working with both Congress and the National Institutes of...Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
...r to symptoms observed in fragile X patients and a mouse fragile X model, FMR1 and dfmr1 must be regulating...ses in human, mice, and flies," states Jongens. A mouse model of Fragile X also shows symptoms similar to those of Fragile X patients. Studies outside of Pe...Schepens scientists regenerate optic nerve for the first time
...ation. The first key involved the development of a mouse model in which the BCL-2 gene is always turned on ...s overexpressing). The second key was the use of a mouse line carrying mutations of "glial specific genes" that lead to the reduced "glial scar" formation. B...Jefferson scientists uncover potential trigger of diabetic kidney disease
...is." Next, the researchers would like to develop a mouse model that overexpresses CD36. "By increasing CD36 levels, we'd like to find out if this does cause the apoptotic pathway with co-existing diabetes," Dr. Sharma says. He notes that there is some evidence showing that CD36 might be involved in vascula...Lack of specific collagen type leads to osteoarthritis
...ied. To examine structures within the cartilage of mouse joints, Leonidas Alexopoulos, Ph.D., developed a n...s extracted key structures within the cartilage of mouse hip joints, which are the size of the ball in a ball-point pen, and analyzed how they responded to t...Female sex hormones play a vital role in defense against sexually transmitted diseases
...d why, and our hope is that by doing these kind of mouse studies, we can understand the mechanisms." In the first study, female mice received either the hormone estradiol or progesterone, a combination of both, or nothing at all prior to exposing them to the herpes virus. Both estradiol and progesterone a...International gathering of experts to share retinoblastoma breakthroughs
... become cancerous. Also, the recent development of mouse models by Dyer's laboratory and several other labo...used cancer. Dyer's laboratory developed the first mouse model in which the mutation occurs only in the retina, which permitted the use of the model for test...Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
...ls in humans similarly to the rise we cause in the mouse should be sufficient to block peroxynitrite," Dr. Hooper says. "Our natural levels of uric acid are not sufficient. Moreover, someone with lower levels who has a spinal cord injury could definitely suffer greater damage."...