Single protein is key in response to bacterial, viral infections
..."This protein, Trif, stands at a crossroads in the mouse innate immune system and, by inference, we believe...earch, Dr. Beutler and his colleagues identified a mouse whose immune system did not react to a substance called endotoxin, a component of bacterial cell wal...Chemical turns stem cells into neurons say scientists at Scripps Research Institute
...ermit precise control over the fate of pluripotent mouse embryonic stem cells--which, like human embryonic stem cells, have the ability to differentiate into all cell types. The scientists screened some 50,000 small molecules from a combinatorial small molecule library that they synthesized at GNF. Just as...Northwestern on trail of gene mutations that trigger sex reversal
...a broad spectrum of point mutations throughout the mouse genome that are passed on to subsequent generations. The various mutations introduced by ENU mutagenesis are then studied and, once there is evidence of a single gene mutation for a given trait, the researchers can pinpoint the gene using positional ...Satellite images predict hantaviral transmission risk
...ed images. The prevalence of SNV infection in deer mouse populations varied among sites. Researchers found ...al conditions and monitor SNV transmission in deer mouse populations and then compare theses sites with lower-risk locations. This approach will help identif...Sepsis vaccine proves protective in preliminary studies at The Scripps Research Institute
...e that [the vaccine] provides good protection in a mouse model, we really want to go on to a clinical working model," says Paul Wentworth, Jr, Ph.D., who is a corresponding author on the paper. The researchers are also now looking to formulate their synthetic glycoconjugate into a slow-release form that ca...Flaxseed-rich diet blocks prostate cancer growth and development in mice
...nal Urology. "The amount of flaxseed given to each mouse was 5 percent of its total food intake, which woul...l group. The experimental group received a regular mouse diet, but 5 percent of the diet was in the form of flaxseed. Half of the mice in both groups were fe...UIC research suggests new way to stop growth of cancer cells
...d by human cancer cells in mice. The test tube and mouse studies indicate that gamma secretase inhibitors warrant further investigation, he says. "This means there is a new potential target against which cancer drugs can be developed." While Miele cautions that more studies are needed to establish which ty...Cholesterol drug could lead to new therapy for multiple sclerosis
...mined the effects of atorvastatin in two models of mouse EAE that may reflect conditions that occur in mult...e disease. Based on the drug doses studied in the mouse models, Zamvil and his colleagues propose using the highest Food and Drug Administration (FDA)-appro...Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases
...ase was minimal in the DLI study, killing only one mouse out of 56, and did not occur at all in the other study. The procedures achieved complete or near-complete chimerism meaning that all, or nearly all, of the animal's blood cells were derived from the donor stem cells, even though the donor animals we...JCI table of contents, November 4, 2002
...e-jci.org/press/16172.pdf Online First The mouse mahoganoid coat color mutation disrupts a novel C3... Impaired renal Na+ retention in the sgk1-knockout mouse CONTACT: Dietmar Kuhl Free University Berlin Institute of Molecular Neurobiology Department of Biol...Jefferson scientists find evidence of greater sensitivity to addictive drugs in adolescence
...in a certain protein in the part of the adolescent mouse brain called the striatum following chronic exposu...ing some of the specific molecules involved in new mouse models. "At this point, many of the drugs that are being used therapeutically and in the treatment o...Ouch! The receptors mediating acidic pain sensation
...than 6.0. Despite experimental data revealing that mouse neurons lacking ASICs are severely deficient in their responses to acidic stimuli, controversy remains about the function of ASICs in mammals. In a study reported in the October 21 issue of the Journal of Clinical Investigation (JCI) by Shinya Ugawa ...New strategy may protect brain against stroke, Parkinson's and Alzheimer's
...that the drugs appear to prevent nerve damage in a mouse model of Parkinson's disease. In another study, the researchers showed that the compounds protect brain cells against beta amyloid, a toxic protein associated with Alzheimer's disease. They are now planning to test the experimental drugs in animal mo...OHSU takes part in unique Alzheimers treatment trial
...nvolves the use of a drug named LY450139, which in mouse models is shown to inhibit an enzyme implicated in the formation of beta-amyloid deposits in the brain. These deposits, also called plaques, may be responsible for brain cell death and decay, and have been connected to Alzheimer's disease. A total of...Starzl Institute researchers to develop cell-based strategy for tranplant tolerance
...ssue or blood, allowed for prolonged survival in a mouse heart transplant model, even without the use of drugs to control rejection. In contrast, the better-known myeloid dendritic cells accelerated the rejection response. According to the researchers, transplant patients who are off immunosuppression hav...OSU cancer researchers win $9.5 to study immunity
... of the projects is the development of appropriate mouse models that offer researchers insight into how various strategies modulating the immune system may actually work in humans. Dr. Yang Liu, a professor of pathology, who will direct this part of the program, recently found subsets of mice NK cells tha...Researchers discover target for new anxiety-reducing drugs
...ved anti-anxiety medications. Through the use of a mouse model, researchers found that absence of a certain...oject. "To conduct this study, we used a strain of mouse that lacks an enzyme called protein kinase Ce (PKCe)," said Raber. "Earlier work showed that this en...Blocking enzyme found to ease anxiety without causing sedation
.... Experiments using brain membranes and studies of mouse behavior showed that knocking out PKC epsilon increases GABA-A receptor sensitivity to neurosteroids, and thereby decreases anxiety. "PKC modulates the modulator," Messing said. Because it is an intermediary, it is a promising focus for drugs that co...Antioxidant reduces brain damage in stroke model
... damaging free radicals and reduce cell death in a mouse model of stroke. AEOL 10150, developed by Dr. Crapo and his colleagues at Duke, mimics the naturally occurring antioxidant superoxide dismutase, but is effective against a wider range of oxygen radicals and lasts longer in the body. Now licensed by I......ed by McIntosh and his colleagues were cloned from mouse progenitor cells and grown in culture. The advantage of NSCs exists in their ability to easily incorporate themselves into their new environment in ways other types of transplants could not. "If you put these cells into normal newborn mice, they wou...