COX-2 product offers good and bad news in 'test tube' strokes
...prostaglandins have a similar protective effect in mouse models of Lou Gehrig's disease, in which excessive glutamate is believed to damage neurons, and will begin work to see if the beneficial side of PGD2 activity can outweigh its toxic activity....Promising treatments for Huntington's disease identified in UCI study
...ly have been shown in other fruit-fly tests and in mouse models to suppress neurodegeneration, but each targets different cellular processes. Included in these combinations are HDAC inhibitors, which also are showing great promise in cancer-treatment clinical trials. When combined, these compounds showed i...New highly active agents against sandfly fever
... antiretroviral activity. Biological trials in the mouse have already confirmed their properties and therapeutic efficacy. Parasitic diseases, especially leishmaniases and trypanosomiases, kill hundreds of thousands of people every year in the world, mainly in the countries of the South. The most severe f...Penn joins major NCI research initiative to advance breast cancer therapies
...was established in 1999 to design and characterize mouse models that more accurately reflect the way that h... 50 institutions in the US and abroad and focus on mouse models for cancers of major organ systems including prostate, breast, lung, ovary, skin, colon, brai...High levels of airborne mouse allergen in inner-city homes could trigger asthma attacks
The amount of mouse allergen found in the air in many inner-city homes...sthma symptoms in animal research lab workers with mouse allergy. "Children living in inner-city homes are continuously exposed to the allergy-causing subst...Newly identified gene cluster on mouse X chromosome provides insights into fertility
...n biology, they already have found two versions of mouse Rhox genes on the human X chromosome - they are bo... genes in male mice. They found that an engineered mouse that lacked a functioning Rhox5 gene exhibited reduced sperm production, as well as sperm motility a...Infectious agent linked to mad cow disease found in organs other than the brain
...ons: liver, pancreas and kidney, in five different mouse models of chronic inflammation. After the mice were infected with prions, the team detected prion accumulation in the inflamed organs. They concluded that the spectrum of organs containing prions might be considerably increased in situations of chron...New way to block pox shows promise in lab study
...ng, made using lab-grown monkey kidney cells and a mouse model of smallpox infection, turns the usual approach to fighting viral infections on its head. By developing drugs targeted to the unchanging chemical pathways used in normal cell processes and co-opted by viruses, the investigators say it might be ...Viral DNA sequence a possible trigger for breast cancer
...sequence of DNA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform bre...protein of MMTV and show that expression of Env in mouse breast cells transforms them. This study puts the spotlight on a potential new mechanism for virus-...Drug treatment promising for halting Huntington's-related nerve death
...other death signals are released. By treating the mouse nerve cells containing the mutant huntingtin protein with these drugs, Dr. Bezprozvanny was able to block the nerve cells from dying. The next step, according to Dr. Bezprozvanny, will be to work with other researchers to test these drugs in whole ...Penn study shows how next-generation diabetic drugs could work more selectively
... lead to these serious side effects. Working with mouse fat cells, Lazar's study suggests that one way to get gene-selective actions would be to target this ability to turn off genes without affecting the ability to turn others on. "Since these are separate processes, one through one type of molecular act...Antibody treatment partially reverses nerve damage in Alzheimer disease
...nerves is reversed, remains, or continues. Using a mouse model of Alzheimer disease in which a subset of neurons and Abeta in the mouse brain express colored fluorescent proteins that can be visualized in the living animal under a micro...JCI table of contents, January 20 2005
...es is reversed, remains, or continues. Using a mouse model of Alzheimer disease in which a subset of neurons and Abeta in the mouse brain express colored fluorescent proteins that can be visualized in the living animal under a micro...Penn researchers add more evidence to demonstrate role of COX inhibitors in heart-disease risk
...ced by COX-1 speeds hardening of the arteries in a mouse model of atherosclerosis, which may have implications for low-dose aspirin therapy in heart patients. Six years ago Garret FitzGerald, MD, Director of the Institute for Translational Medicine and Therapeutics at Penn, raised the possibility that sele...MGH researchers find way of regenerating cells key to hearing
...ssment of which genes are active in the developing mouse ear and when the are expressed. The activity of c...ation, the researchers used a genetically modified mouse strain in which Rb was no longer made in the inner ear. They found that hair cells in the ears of...Gene vaccine protects mice against development of Her2/neu breast cancer
... control mice developed breast cancer but only one mouse in each of the VRP-neu groups did. In short, 86 pe...e mice three times with VRP-neu, and "not a single mouse developed a tumor," says Lachman. Lachman suggests the vaccine might prove helpful in keeping human ...Antibiotics protect nerves in mice by turning on genes
...ls. Because we study ALS, we tested the drugs in a mouse model of that disease, but this is much bigger than ALS. This approach has potential applications in numerous neurologic and psychiatric conditions that arise from abnormal control of glutamate." A large, multi-center clinical trial planned for the s...Residual tumor cells are a barrier to targeted cancer therapeutics
... the group found that after turning off c-MYC in a mouse model, 50 percent of c-MYC-induced mammary cancers... concludes that the type of genetically engineered mouse models used in these MYC studies yield results that are very similar to what is observed in patients...Chemicals found in cherries may help fight diabetes
...anthocyanins extracted from these cherries against mouse pancreatic-beta cells, which normally produce insulin, in the presence of high concentrations of glucose. Insulin is the protein produced by the pancreas that helps regulate blood sugar (glucose) levels. Compared to cells that were not exposed to ant...Early learning leaves lasting changes in brain, Stanford owl study shows
...he sounds an owl hears, such as the squeaking of a mouse or some rustling in the leaves. The owl then uses ...owl first peers through the new specs, a squeaking mouse located off to the side appears to be straight ahead. This confuses the owl and allows its prey to e...