Surprise! Cells have second source of phosphate
...Rashna Bhandari, Ph.D., mixed it with a "puree" of mouse brain or kidney, which produced hundreds of radioactive proteins. After numerous experiments to rule out other possibilities, the researchers could finally conclude that IP7 gives away its extra phosphate to proteins. "We think IP7 phosphorylation of...Researchers find circulating tumor cells in long-term cancer survivors
...removed." Based on his previous data gathered from mouse models of cancer dormancy, Dr. Uhr and colleagues used a stringent and sensitive set of tests to identify CTCs in women who had mastectomies and had been clinically cancer-free for at least seven years. The investigators collected blood from 36 stud...Researchers describe how human blood stem cells transform themselves to repair injured animal hearts
... sophisticated way of examining the "humanness" of mouse heart cells, researchers report in the December 21... the heart. Human stem cells primarily "fuse" onto mouse cardiac cells to produce new muscle (myocyte) cells that have both human and mouse DNA. But to form ...UGA researchers receive NIH contract to create a stem cell-based drug assay for SMA
...s in the spinal cord from degenerating. Transgenic mouse models, developed to study SMN function, have been informative, said Stice. However, typical model systems, such as the mouse, possess only one SMN gene and research has found that the initial survival of human SMA patients depends on protein produce...Stanford study finds new method improves chemotherapy survival in mice
...nfusion of a type of bone marrow cell from a donor mouse yielded significantly more neutrophils in the laboratory mice a week after a dose of a typical chemotherapeutic agent. The procedure also increased the animals' ability to fight a deadly fungal infection. The team's findings appear in the Dec. 15 iss...Study suggests Akt3 protein is key to melanoma's resistance to chemotherapy
...velopment. Robertson's team confirmed this using a mouse model, finding that decreasing Akt3 activity using siRNA or reintroducing the missing PTEN protein halted tumor progression. "Identifying Akt3 as a possible target to halt the growth of and kill melanoma cells provides new opportunities to develop t...O Christmas tree: Your bark may fight arthritis
...searchers then tested the various extracts against mouse inflammatory cells (macrophages) for their ability to produce nitric oxide and prostaglandin E 2 (PGE 2 ), chemicals which are known to help trigger inflammation when they are produced in excess amounts, as during disease or injury. The results were...Broad-based vaccination of wild mice could help reduce lyme disease risk in humans
..., such as the white-footed mouse. The white-footed mouse is considered a key animal reservoir for Lyme dise...sease. After immunizing roughly 55 percent of the mouse population over the course of the two studies, researchers saw an overall reduction of 16 percent in...Fred Hutchinson receives $9.7 million to lead early detection consortium
...markers that are associated with several different mouse models of human cancer, including those of the bre... at the University of Washington, focuses on using mouse models of human cancer to understand how environmental exposure to carcinogens interact with genes t...M. D. Anderson researchers discover key protein in psoriasis
...ver the cause of psoriasis and developed the first mouse model that fully mimics the human disorder. What's... block the signals that lead to psoriasis in their mouse model with a topical skin treatment that can prevent new outbreaks as well as treat existing psoriat...Novel antibiotic shows promise in shortening treatment duration of tuberculosis
...er and faster than the current standard of care in mouse models of TB infection. Also, preliminary studies...ericidal, meaning that it kills the TB bacilli. In mouse models, the studies showed that a cocktail regimen containing this compound reduced bacterial load a...Scientists align billion-year-old protein with embryonic heart defects
...opkins University School of Medicine. They studied mouse embryos, using genetic trickery to nullify SRF in heart cells and key blood vessel cells called smooth muscle cells. They compared the mutant mice to those with a normal amount of SRF in the heart and blood vessels. The heart and related vessels did ...Stressed mice quicker to get skin cancer
...sk exposed 40 mice to the scent of fox urine - the mouse equivalent of big-time stress - and large amounts of UV light. The first skin tumor in one of the mice appeared after eight weeks of testing. Mice exposed only to UV light began developing tumors 13 weeks later. By 21 weeks of testing, 14 of the 4...New technique scans electrical 'brainscape'
...animals. "Also, there exist many mouse models of neurological disorders, and we can use this technique to explore how the brain functions in those models. For example, we can understand the global dynamic structure of the brain in Parkinson's disease, Alzheimer's disease or schizophrenia....VGTI researchers help uncover why aging reduces immune system function
...how that increasing TCE cells in a normal, healthy mouse reduces that animal's ability to fight disease. "While this work is still in the early stages, we think it might be of great value," explained Nikolich-Zugich. "If we can find ways to limit the production of TCE in the aging, we might be able to k...Rolipram - a potential new treatment for Alzheimer disease
...y loss. The authors show that brief treatment of a mouse model of AD with a phosphodiesterase 4 inhibitor, rolipram, improves memory in both long-term potential and contextual learning both measurements of brain function. Rolipram's protective effect is due to its ability to modify gene expression, makin...New drug protects against the hardening of arteries
...gonists on the development of atherosclerosis in a mouse model of this disease. They observed profound protective effects of the PPARalpha agonist GW7647, comparable to the PPARgamma agonist rosiglitazone that is currently used to treat type 2 diabetes. GW7647 also reduced weight gain, and insulin and lipo...Molecular tailoring of chemotherapy with novel imaging techniques
...s. The experiments, now in human cell cultures and mouse models, are aimed at better forecasting early resp...ry and colleagues combine imaging techniques and a mouse model for colon cancer. "In this research, we're combining two very powerful emerging technologies,"...Herpes virus offers new hope in curing cancer
...ors. Researchers successfully treated the tumor in mouse models by administering a treatment based on a weakened version of the herpes simplex virus. The study appears in the current online issue of Pediatric Blood and Cancer, the journal of the American Society of Pediatric Hematology/Oncology. Neuroblast......n fat cells and macrophages via cytokines, both in mouse and humans." These studies demonstrate that blood levels of resistin are a marker for inflammatory disease, and suggest a potential causative role for resistin in the insulin resistance that is seen in patients with serious bacterial infections ...