New research shows stomach (gastric) cancer originates from bone marrow derived stem cells
...omach cancer cells. The research was conducted in mouse models. "With this clearer understanding of the connection between bone marrow derived stem cells and stomach cancer, I plan to establish screening models for people at high risk of cancer and work to translate the findings into new treatments tha...Estrogen-associated COX-2 pathways explain protection from heart disease in female mice
...es have shown that estrogen slows heart disease in mouse models, but the mechanism is largely unknown. Now scientists from the University of Pennsylvania School of Medicine show for the first time that in female mice protection from hardening of the arteries purported to come from higher levels of estrogen...American Thoracic Society journal news tips for November 2004 (second issue)
... FOR MURINE TUBERCULOSIS In a study employing a mouse model of tuberculosis (TB), researchers used a combination of rifampin, moxiflocacin, and pyrazinamide to shorten the time to negative cultures in the rodents by 2 months. Their improved results with moxifloxacin at 4 months were in direct contrast ...USF neuroscientists awarded $1.1 million NIH grant to improve Alzheimer's vaccine
...y and effectiveness of an Alzheimer's vaccine in a mouse model. "This approach shifts the focus from treating symptoms of Alzheimer's disease to treatments that slow down the disease or prevent it altogether," said Jun Tan, MD, PhD, director of the Neuroimmunology Laboratory in the USF Department of Psych...Mouse model gives insight to human hair loss
...dy the disease known as alopecia areata (AA). "Our mouse model has proven to be very useful as a preclinica...logy, researchers identified a virtually identical mouse model for human adult onset AA and were able to reproduce the disease for exploring treatments. Dat...Signaling pathway may be key to understanding roots of hypertension
... developed a Gq inhibitor and tested it in various mouse models of hypertension. They looked at two particu...ng hypertension in mice. When they mated the GRK2 mouse with a mouse with a genetic inhibition of Gq, the resulting offspring had lower blood pressure. But ...New insights into muscle adaptation to exercise
... The Duke team performed their experiments using a mouse model of voluntary exercise. This experimental approach is important, they explained, because most skeletal muscle adaptation studies utilize electrical stimulation of the muscle, which is much less physiologic and does not as closely mimic what woul...New compounds effective against Alzheimer's disease onset and progression
...an amyloid beta (Ab)-induced glial activation in a mouse specially designed to develop many of the hallmarks of Alzheimer's disease pathology, including neuroinflammation, neuronal and synaptic degeneration and amyloid disposition, often called plaques. Inhibition of neuroinflammation correlated with a de...Mayo Clinic discovers one mechanism for why men and women differ in immune response
...ys. "We also demonstrated that if you take a male mouse and treat it with chemotherapy you can prompt the mouse to recover its immune system much more quickly simply by removing androgen." When testosterone is re...Longterm immune memory cells cells do not develop during chronic viral infections
...rotective immunity. The Emory researchers used a mouse model of infection with lymphocytic choriomeningitis virus (LCMV) to study the differences in CD8 memory T cell immune response following acute and chronic infections. In mice with the acute infection, the virus was cleared by a CD8 T cell immune re...Scientists pinpoint flaw, offer new promise for stroke treatment
... medicine, an APC expert whose laboratory provided mouse APC for the study, as well as staff member Jose Fe...ubling in human brain cells and nearly doubling in mouse neurons. Then the researchers showed that APC counters the harmful effects of tPA remarkably. In hu...FOSRENOL (R) maintains bone health status of end-stage renal disease patients
...anthanum carbonate also tested negative in an oral mouse micronucleus assay at doses up to 2000 mg/kg (1.7 times the MRHD), and in micronucleus and unscheduled DNA synthesis assays in rats given IV lanthanum chloride at doses up to 0.1 mg/kg, a dose that produced plasma lanthanum concentrations >2000 t...Scientists identify key mechanism in estrogen's role in preventing bone loss
...e-marrow density, the scientists used a transgenic mouse model in which TBFb signaling in T cells is blocked. Although these mice had the same level of bone density as control mice at birth, they gradually lost bone density over time, suggesting that when T cells are insensitive to TGFb signaling, they st...Research on nerve cell circuitry reveals clue about schizophrenia
...ients with schizophrenia. "Through our research on mouse brain nerve cell circuitry, we have shown that thi...ents." Hegde and colleagues studied a part of the mouse brain that has two major types of nerve cells similar to the nerve cells that malfunction in people ...Marijuana-like compounds may aid array of debiliating conditions ranging from Parkinson's to pain
...g life by three years or more." In the study, ALS mouse models were given either the marijuana compound TH...even days and extended survival by six days in the mouse model," says Abood. "This corresponds to three years in human terms." Results also indicate that th...Researchers identify brain protein that halts progression of Alzheimer's
...xhibit symptoms of Alzheimer's disease. "We have a mouse whose brain is bathing in toxic beta-amyloid witho...had increased dramatically. When Stein treated the mouse brain with an antibody that prevented transthyretin from reacting with the beta-amyloid protein, the...New oral vaccine for Alzheimer's disease
...or more than 6 months. Immunohistochemistry of the mouse brain tissue showed that the extra-cellular amyloid deposits were clearly decreased compared to the non-treated mouse. Hideo Hara, M.D, writes "This new oral vaccine does not induce strong T cell immune reactions, and hence it could reduce the side e...New hope for ALS seen with genetic techniques, growth factors
...he University of California at San Diego created a mouse model of ALS with a mutation in the enzyme copper-... VEGF levels could better protect against ALS in a mouse model. The investigators first delivered VEGF to the brains of ALS rats with a surgically implanted...Olfactory bulb stem cells and Lou Gehrig's disease
...Hopkins researchers have found that transplants of mouse stem cells taken from the adult brain's olfactory bulb can delay symptoms and death in a mouse model of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. They are scheduled to present......larger cages with running wheels, tubes, and other mouse toys. The toys were varied from day to day. At 10 weeks of age, the ovaries of the mice were removed to simulate the long-term estrogen losses seen in menopause. At six months of age, the mice were then treated with estrogen or a control substance an...