Novel drug-antidote strategy provides greater control of drug action
..., the aptamer drug-antidote pair was successful in mouse models. The drug effectively prevented arterial thrombosis in murine thrombosis models, and the additional safety of the drug conferred by the antidote was demonstrated in murine surgical challenge models. Mice were treated with high doses of the ant...U. Va. researchers unravel a central mystery of how hearing happens
... functional development of inner ear hair cells in mouse embryos. This breakthrough helped them identify that the TRPA1 gene was turned on during the same 18-hour period, sending the U.Va. scientists down the path to discovery. "Now that we've identified TRPA1 as the hair cell transduction channel,"...New way of controlling cholesterol may help treat Alzheimer's
...es earlier than males do. Biochemical analysis of mouse brain tissue showed that the inhibitor probably prevents amyloid-beta production, rather than reducing its deposition. To evaluate the effect of ACAT inhibitor treatment on the mice's cognitive abilities, the researchers had groups of treated ...Long-sought key to hearing may be found in protein discovery
... systematically evaluated all of the several dozen mouse TRP channels with RNA probes to locate the ones expressed by hair cells of the mouse cochlea. TRPA1 looked most promising. Using antibodies to TRPA1, the team found that the channels we...Lithium may protect neurons from radiation therapy
... other areas of the brain. However, treatment of a mouse hippocampus cell with lithium for a week prior to 3 Gy of radiation resulted in a 60 percent increase in cell survival; a week's treatment with lithium prior to a radiation dose of 6 Gy resulted in a 70 percent increase in cell survival. The research...News tips from the Journal of Neuroscience
...et al. create a tetracycline-regulated conditional mouse model of SCA1. They found that when the gene was disabled early in the course of the disease, the pathology was remarkably reversed. Even performance on the complex accelerating rotarod motor task was restored. This is good news for these mice and ma...A glass of red wine a day may keep prostate cancer away
...ey also plan to test the effects of resveratrol on mouse models of prostate cancer to see if giving mice this chemical compound will reduce the onset of prostate cancer and/or decrease the aggressiveness of the disease. The first author of the study, W. Marieke Schoonen, M.S., formerly a graduate student...Other highlights in the September 15 JNCI
...cine in St. Louis, and colleagues demonstrate in a mouse model of human breast cancer that a mammaglobin-A cDNA vaccine reverses tumor growth in mammaglobin-A expressing breast tumors. They conclude that mammaglobin-A immunotherapy shows potential as a treatment for breast cancer. Contact: Gila Z. Reckess,...Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
... pharmaceutical chemist is looking to step up from mouse studies to Phase I clinical trials. One in seven women will develop breast cancer, according to the American Cancer Societys 2004 report of cancer statistics. Closely tied to deciding the best approach for the tumors removal a lumpectomy is now the ...Highlights of Washington University Alzheimer's Research at National Conference
...vels may help predict onset of the disease. In a mouse model of Alzheimer's disease, a drug that is designed to clear deposits of Abeta42 out of the brain was found to help reverse damage to brain cells. Preliminary evidence suggests people with Alzheimer's disease may be less likely to develop cancer ...Mouse shows how Rituximab removes human B cells
...(and normal) B cells is unknown. Research in a new mouse model reported in The Journal of Experimental Medi...eated mice with a panel of antibodies specific for mouse CD20 (Rituximab is an antibody that binds to human but not mouse B cells). The antibodies that were ...National study shows 82 percent of U.S. homes have mouse allergens
...Health (NIH), have found that detectable levels of mouse allergen exist in the majority of U.S. homes. NIEH...tics. 82 percent of U.S. homes were found to have mouse allergens. The findings by Cohn et al. appear in the June 2004 issue of the Journal of Allergy and C...Cells from fat tissue turned into functional nerve cells
...s, the researchers transformed cells isolated from mouse fat, also known as adipose tissue, into two important nerve cell types: neurons and glial cells. Neurons carry electrical signals from cell to cell, while glial cells surround neurons like a sheath. "We have demonstrated that within fat tissue there ...New technology shows axons are extremely sensitive to directional cues
...cience . Similar to connecting your PC, monitor, mouse and printer correctly to make all computer parts work, the developing brain needs a series of critical wiring connections to be made for it to function properly. But, unlike computers that come with a user and troubleshooting manual, nerve fibers cal...Alzheimer's pathology reduced, longevity improved in mouse model, Gladstone study shows
...euroscience (May 12, 2004). Using well-established mouse models of Alzheimer's disease, the investigators examined how changing levels of the enzyme Fyn affects key aspects of the disease, including accumulation of large clumps of amyloid proteins in the brain (so-called plaques) and changes in the complex...Cutting-edge science offers improved care for liver diseases
...e effects and efficacy of transplants, because the mouse model does not reject engraftment (growth and development within the liver). In each model, the UCB cells were evaluated for engraftment and production of albumin (ALB, a protein indicating proper liver function) from three to 55 weeks after transpl...Researchers identify cancer-causing gene involved in aggressive leukemia, lymphoma
...ood cells, the Hopkins researchers found that each mouse quickly developed cases of leukemia and lymphoma s...cerous transformations. "We believe the transgenic mouse used in this study will also provide a valuable tool for determining how overexpression of the HMG-I...Mechanism found that may protect kidneys in early stages of diabetes
...ntrol of blood pressure, in the kidneys of a young mouse model of obesity and diabetes. The mouse, called d...ty and an increase in ACE2 expression in the young mouse model, is similar to a pattern seen after administering a kidney-protecting drug and ACE inhibitor c...Disruption of a gene may prevent type 1 diabetes, UVa researchers find
...ented the development of spontaneous diabetes in a mouse model, revealing an important role for the Stat-4 gene in the pathogenesis of type 1, also known as autoimmune diabetes. Type 1 diabetes occurs when the body's immune system goes haywire and attacks the insulin-making beta cells of the pancreas. Peop...Scientists uncover how brain retrieves and stores older memories
...used a series of strategies with mice, including a mouse model with an altered form of a gene called CaMkinase II, which eliminates the ability to recall old memories, to identify the role of the anterior cingulate cortex. "Most people define memory as their collective lifetime experiences. These memories ...