Researchers define mechanism that enables stem cells to track migrating brain tumor cells
...nai's Maxine Dunitz Neurosurgical Institute, using mouse and human cells, have defined a subset of neural stem cells that have this tumor-tracking potential. They also have identified a biochemical mechanism that appears to govern the homing behavior. Their results appear in the May/June issue of the journ...OHSU researchers uncover genes involved in early stages of Alzheimer's disease
...l Human Molecular Genetics. "Through studying a mouse model of Alzheimer's, the research team found that...ffect of Alzheimer's disease. By studying 11,283 mouse genes and using a gene chip technology called microarray, OHSU scientists were able to identify a mu...Study: New neurons can get out of spinal cord
... researchers -- have been grown in the presence of mouse cells, which many scientists believe makes them un...is culturing muscle cells with ES cells taken from mouse models of ALS and SMA. He hopes to plot what goes wrong and when at the molecular level. "We should ...Alzheimers disease - recent discoveries pave the way toward new treatments
...ly informative changes in the brains of transgenic mouse models of Alzheimer's disease, and we have begun t...seases such as Alzheimer's. Genetically engineered mouse models are especially useful tools for studying neurodegenerative disease because they allow individ...Nitric oxide links bulk of sporadic and familial Parkinson's disease
...hed to parkin and regulates its activity. But in a mouse model of PD and in patients with PD or a similar condition called diffuse Lewy body disease, NO modification was so high parkin couldn't do its job at all. "We looked at NO modification of parkin step-by-step from the most basic level of biology -- a...Two-way link between heart disease and autoimmunity
...ading cause of death in the developed world. A new mouse model, reported by Kenneth Walsh and colleagues in...disorders, the authors crossed an autoimmune-prone mouse with another that develops atherosclerosis to create a new mouse strain with susceptibility to both ...UCSD researchers determine fibrin depletion decreases multiple sclerosis symptoms
...lerosis (MS) is reduced and lifespan lengthened in mouse models of the disease when a naturally occurring fibrous protein called fibrin is depleted from the body, according to researchers at the University of California, San Diego (UCSD) School of Medicine. The study, reported online the week of April 19...Second NIAID SARS vaccine candidate helps mice fend off SARS
...a Subbarao, M.D., whose lab recently developed the mouse model of SARS infection. In the current study, two groups of eight mice received doses of the MVA/S vaccine, delivered either into nose or as an injection into muscle, four weeks apart. One month after the second immunization, the rodents were expose...Researchers identify leukemia-linked pathway targeted by a new kinase inhibitor
...he team developed the first efficient and accurate mouse models of both forms of BCR-ABL1-induced leukemia....i and his team are currently developing additional mouse models lacking in different combinations of the Src kinases, in an effort to make available a range ...When 'switched on' muscle stem cells morph to resemble nerve cells
...rily has been studied using bone marrow cells, but mouse experiments that suggested these stem cells could convert to nerve cells have been controversial. Some investigators suspect that manipulated bone marrow cells are either contaminated with neural stem cells or get fused with neuronal stem cells pres...Inactivation of Alzheimer's disease genes in mice causes dementia and brain degeneration
...emory loss and gradual death of nerve cells in the mouse brain. The researchers identified the molecular pa...pital and Harvard Medical School, created a unique mouse model that allowed them to examine the consequences of blocking presenilin function in the adult bra...NIAID vaccine protects against SARS virus infection in mice
...ne. The vaccine was tested in a recently-described mouse model of SARS infection with other NIAID investiga... Infectious Diseases, who recently established the mouse model of SARS infection. Testing the vaccine in mice demonstrated its effectiveness and also helpe...Existing therapies applied to new use in broader spectrum of cancer care
...e cancer cells both in culture and in vivo using a mouse model for colon cancer. After confirming the presence of GABA receptors in the colon cancer cell lines, the researchers documented a marked reduction in cellular cAMP concentrations in colon cancer cell lines treated with Nembutal. ...An alternative to bone-marrow donation
...the most effective mix of growth factors to induce mouse ES cell lines to develop into bone-marrow and blood precursor cells in culture. They also devised a method to select the best cells from these cultures. Injection of the selected cells into the bone marrow of mice that had been depleted of their own ...Advances in prevention and treatment research hold promise for 'pipeline'
...erated strong peptide-specific immune responses in mouse models and antibodies capable of generating partial protective response in the cottontail rabbit model. McCormick and her colleagues are now performing research focused on improving these novel vaccines against papillomaviruses through research fun...Nanotech imaging, molecular fingerprints and signatures hold promise for cancer
...performance. The performance of G6 was observed in mouse models for breast cancer. The researchers look...nce of this agent on the clinical machinery in the mouse model, and we expect the drug to perform as well in the human. "If the drug is approved for human u...Mouse model mimics real-world plague infection
... proved 100 percent effective when tested in a new mouse model for plague infection developed by scientists at Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The scientists developed their model to mimic th...Mechanism leading to life-threatening infection identified by UCSD School of Medicine researchers
... the journal Nature, the lab-culture research with mouse cells identifies a protein kinase called PKR that causes the death of macrophages, the large white blood cells that act as the body's first defense against pathogens. Without macrophages to detect, engulf and stop the invading bacteria, the infectio...Mouse antibodies thwart SARS virus
... The embargo for this release has been lifted. The mouse immune system develops antibodies capable of singl...be infected with the SARS virus and if so, how the mouse immune system responded. Initial experiments revealed that while the SARS virus did not make the mic......f large cells on the surface layer of cells in the mouse ovaries that they proved to be germ cells (stem cells that are precursors to oocytes and are not associated with follicles). They also found signs in adult animals of meiosis, the specialized cell division that only occurs in the formation of sex ce...