Progenitor cells predict heart disease severity
...9, 2003), Duke researchers reported discovering in mouse studies that a major outcome of aging is an unexpected failure of the bone marrow to produce EPCs needed to repair and rejuvenate arteries exposed to a genetically induced risk of high lipid levels. The researchers demonstrated that an age-related lo...Environmental enrichment lessens protein deficits in mouse model of Huntington's
...ion of Huntington's disease, researchers show in a mouse model of the disorder. Levels of brain-derived ne... at first, then accelerating. The amount of time a mouse remained on the rotating rod was a measure of Huntington's disease-associated motor symptoms. In tra...Jefferson Alzheimer's vaccine shows promise in animal model
...ease and Associated Disorders. While a mouse model of Alzheimer's is well established, research...in the late 1990s created a transgenic Alzheimer's mouse with human genes. They vaccinated the mice with beta-amyloid and found a dramatic clearing of the am...Mouse model of neuromuscular disease identifies key player in motor neuron death
Scientists have created a new mouse model for spinal and bulbar muscular atrophy (SBMA), a disease characterized by adult-onset progressive weakness and degeneration of limb muscles, often resulting in the patient being confined to a wheel chair. SBMA causes the death of cells called m...Jefferson scientists unlocking secrets of cholesterol transport in body
...d a similar close association of these proteins in mouse intestinal cells not found in other cells. When the team treated mice that were fed a high fat Western diet with Zetia, the two proteins separated. "This was truly an unexpected result," Dr. Farber says. "How cholesterol levels can influence the ab...A new protective protein against Parkinson's disease
...nt mutation has a protective effect on axons in an mouse model of Parkinson's disease. Parkinson's disease ...ought to assess the effects of the Wlds protein in mouse model of Parkinson's disease. The researchers found that following injection of a dopamine toxin in ...Two proteins may help prevent Alzheimer's brain plaques
...delay or prevent the development of plaques in the mouse model and to explore the potential for drugs or gene therapy to reverse plaque formation in mice....Scientists identify cell defects that limit immune system's impact on late-stage tumors
...s Maxine Dunitz Neurosurgical Institute, where the mouse studies were conducted. "Furthermore, we were able to influence the cells in a way that decreased the number of dysfunctional cells, a finding that we hope may eventually lead to more effective vaccine therapies against established tumors." In a loca...One dose of 'designer' gene therapy may target specific body area
...rable infectivity for vascular ECs, Baker said. In mouse studies, the modified viruses accumulated at lower levels than the wild type in the major organs, predominantly the liver. Secondly, the modified AAV remained in the blood circulation longer than wild-type AAV, presumably because of reduced liver se...Understanding nerve degeneration in spastic paraplegia
...enetics and Medicine in Naples, Italy, developed a mouse model for studying HSP due to mutations in the Spg7 gene, which encodes the enzyme paraplegin. Paraplegin-deficient mice were affected by axonal swelling from failed axon transport, and axon degeneration. Long before this swelling ocurred the authors...Scientists restore crucial myelin in brains of mice
...stimates that about 10 percent of the axons in the mouse brains were remyelinated, compared to a tiny fraction of 1 percent in previous studies. Currently, demyelinating diseases are permanent, and problems worsen as time goes on because there is no way to fix the underlying problem restoring the ...Other highlights in the January 7 issue of JNCI
... growth of neuroblastoma cells in culture and in a mouse model, suggesting that the drug should be tested a... growth of neuroblastoma cells in culture and in a mouse model. They found that neuroblastoma cell lines treated with imatinib displayed concentration-depe...First link found in humans between common gene and artery-clogging disease
... Allayee says. The team's work was driven by a mouse model developed by Margarete Mehrabian, Ph.D., sen...e first to show that eliminating the gene from the mouse genome helps protect against atherosclerosis, even when the rodent ate a fat-heavy diet. Other resea...A pair of discoveries helps unravel complex genetics of inflammatory bowel disease
...ciation between IBD and the MDR1 gene. Like NFKB1, mouse genetic studies similarly suggested that the MDR1 gene was important in colitis, alerting researchers to the potential importance of MDR1 to human IBD. "Taken together, these new discoveries combine with the original NOD2 gene discovery and will hop......e of Physicians and Surgeons in New York studied a mouse model with a heterozygous deletion of beclin 1 and observed an increase in cellular proliferation and the frequency of spontaneous malignancies, and reduced autophagy. The report demonstrates that the autophagy gene beclin 1 has a tumor suppressor fu...Glycerin may help skin disease, study finds
...er-proliferative, thick skin," Dr. Bollag says. A mouse model for dry, flaky, unnaturally thick and slow-h... have that glycerol channel," Dr. Bollag says. The mouse research was published in the Journal of Investigative Dermatology about the same time Drs. Bollag a...Experimental drugs show promise in halting brain tumors
...epresented a "significant effect," given that most mouse tumors grow in a few weeks whereas most patients with glioblastoma live for approximately one year from the time of diagnosis. The drug worked by blocking angiogenesis, the process by which tumor cells grow new blood vessels. Specifically, ZD6474 blo...Jefferson scientists find radiation and blood vessel inhibitor more effective against brain tumors
...growth of a common brain tumor, glioblastoma, in a mouse model. VEGF Trap is a protein engineered to block VEGF activity. The particular type of brain tumor expresses high levels of VEGF and is resistant to treatment with many other antiangiogenic drugs. According to Dr. Dicker, who is also director of the...New evidence links inflammation to venous disease
...the first to evaluate microparticle formation in a mouse model of DVT," Myers says. "We found that when P-selectin binds to its receptor, it seems to release these pro-coagulant microparticles, which accelerate the clot-forming process. Mice with more leukocyte-derived microparticles developed larger blood......ockade of IL-15 biological activity in a xenograft mouse model AUTHOR CONTACT: Janine Schuurman Genmab, Utrecht, The Netherlands. Phone: 31-30-212-3126 Fax: 31-30-212-3111 E-mail: j.schuurman@nl.genmab.com View the PDF of this article at: https://www.the-jci.org/press/18986.pdf ************************...