Regeneration of insulin-producing islets may lead to diabetes cure
...betes Center, notes, "These exciting findings in a mouse model of Type 1 diabetes suggest that patients who are developing this disease could be rescued from further destruction of their insulin-producing cells. In addition, patients with fully established diabetes possibly could have their diabetes rever...Researchers identify enzyme that may turn fleeting experience into lasting memory
...nize their partner's scent. After mating, a female mouse exposed to the scent of a strange male will not co...del, formation of the lasting memory in the female mouse requires that olfactory (smell) information about her partner coincide with sensory information abou...Nicotine metabolite shows promise for improving memory, protecting brain cells
...r. Buccafusco's lab recently received a transgenic mouse model for Alzheimers' that develops Alzheimer-like plaques in the brain within the first year of life. One of his graduate students, Ajay Sood, will use this model for his thesis, studying the neuroprotective potential of cotinine, nicotine and simil...Brain signals from the paralyzed or injured captured by computer
...signals like voice or eye movement to manipulate a mouse or keyboard," said Donoghue. "The advantage of Bra...rain activity into the intended hand movement over mouse or keyboard." The BrainGate BCI consists of a microelectrode array sensor implanted into the motor c...Panel: Clinical use of embryonic stem cells jeopardized by Bush's policy on federal funding
...yonic stem (ES) cell lines were initially grown on mouse cells and therefore might harbor mouse-specific vi...ally, potentially exposing study participants to a mouse virus -- which people's immune systems might be unable to combat -- is not a risk worth taking in th...Jefferson Scientists define new cell type that may lead to clues about Kaposi's sarcoma
...Tohuku University in Sendai, Japan, have created a mouse model that resembles an early form of KS. To accom... this, they have grown and characterized a line of mouse skin cells in the laboratory that they believe are analogous to the cells that go awry early on in h...Gene therapy establishes a TRAIL to arthritis treatment
...imits the incidence and severity of arthritis in a mouse model of collagen-induced arthritis and joint inflammation. The regime represents a therapeutic option for systemic rheumatic diseases. Mountz and colleagues isolated dendritic cells prepared from either peripheral blood or bone marrow, which were th...Radically new anti-rejection drug shown to offer safe control of immune system in Stanford study
...l be limited." Initial results testing the drug in mouse organ transplantation were promising at Pfizer, but organ transplantation in monkeys is much more challenging. Borie led the Stanford transplantation immunology team that tested the drug's effectiveness in cell cultures and in kidney transplants in m...Studies show Tim-3 proteins key to immune responses
...TH1 response against insulin-producing cells. In a mouse model of tissue transplants, they found that mice with no Tim-3 rapidly rejected the transplants, despite receiving treatments that normally ensured transplant survival. Likewise, in their paper, Kuchroo and colleagues demonstrated that Tim-3 deficie...New mouse model of Alzheimer's, other diseases may clarify steps of brain degeneration
BOSTON, MA A new mouse model developed by Harvard Medical School research...heimer's and NiemannPick type C. But the lack of a mouse model prevented researchers from demonstrating in vivo the effects of Cdk5 and p25 in the brain. Tsa...Study finds way to dramatically increase hematopoietic stem cells
...se the production of hematopoietic stem cells in a mouse model. Expanding the population of these cells, which can develop into any kind of blood cell, could greatly increase the number of patients who could receive stem cell transplants for certain cancers. The study, published in the Oct. 23 issue of Na...Evidence that neurons prune only 'twigs' to rewire themselves
...e highly active olfactory processing region of the mouse brain. Such evidence suggest that dendrites in the...these diseases." For example, he said, by crossing mouse strains that show epilepsy with the fluorescently tagged strain, it would be possible to study in de...Brain may 'hard-wire' sexuality before birth
...s produced in different amounts in male and female mouse brains, prior to hormonal influence. Eighteen of the genes were produced at higher levels in the male brains; 36 were produced at higher levels in the female brains. "We didn't expect to find genetic differences between the sexes' brains," Vilain sai...New centers boost muscular dystrophy research
... success with viral vectors in delivering genes to mouse muscle. Investigators will use animal models to study several aspects of gene therapy to guide the development of human trials. This center will also conduct translational studies on several other types of muscular dystrophy to accelerate the develop...MSU site of national breast cancer center
...function of estrogen and progesterone receptors in mouse models. In particular, we will focus on the role of progesterone in breast development and as a risk factor for breast cancer. "I've spent most of my career studying hormonal regulation of breast development. In addition, colleagues from several MSU...UCSF & SF Bay Area receive federal funds to expand breast cancer / environmental research
...field of mammary gland development, she will use a mouse model to study cell responses to a variety of environmental stressors. Kaiser's Kushi will lead an epidemiologic study following a cohort of Bay Area seven- and eight-year-old girls through puberty. The goal of this project is to better understand t...Jefferson and Michigan scientists identify gene defect behind muscle-wasting disease
...f Dr. Meisler's research team, discovered the mnd2 mouse model, an inherited neurological disease, in 1990....chromosome 2p13.1 which happened to correspond to mouse chromosome 6, where the mnd2 locus is found he suspected that a mutation in the Omi/HtrA2 gene coul...Understanding Alzheimer's disease: Animal research points to new direction for therapy
...yzed the accumulation of amyloid beta protein in a mouse model of Alzheimer's disease....'Genetic switch' proves two mechanisms exist by which immune system cells differentiate
..."lucky accident," the team, in trying to produce a mouse with a fluorescent protein under control of the nude gene, came up with something entirely unexpected. The mouse, with the nude gene absent, should have been born completely without hair. Instead, its hair came in and grew normally. At first, the tea...The neighborhood matters: Packard Center scientists show cell environment is important in ALS
... neighborhood may be everything, if a new study in mouse models of the disease holds true for patients. AL...ld type cells mixed in had the effect of extending mouse survival from one to eight months, depending on the number of cells and type of SOD1 mutation. In a ...