It's the neighborhood that matters in ALS, according to medical researchers
...Diego (UCSD) School of Medicine, has determined in mouse models of amyotrophic lateral sclerosis (ALS) that...cing motor neurons to die, the researchers studied mouse models of ALS with a mutation in the gene superoxide dismutase (SOD1). The most common inherited fo...Disrupting two cell mechanisms in combination can suppress aggressive breast cancer in mice
...ed that express the HER2/neu activated oncogene, a mouse model of breast cancer that is much more similar t...use we have been able to create more sophisticated mouse models that over express the oncogenes found in 25 to 30 per cent of human breast cancer, these mode...'Good' chemical, neurons in brain elevated among exercise addicts
...ing mouse's inability to learn as well as a normal mouse could be due to less biological reasons, Rhodes po...ot known. Rhodes suggests that when a high-running mouse exercises, stress is placed on its hippocampus and the development of new neurons becomes a protecti...Antigen targeted in therapy for melanoma also prompts immune response in brain tumor cells
... ways to target and boost the immune response." In mouse and human studies of melanoma, tyrosinase-related protein-2 (TRP-2) has proved to be an excellent target for immunotherapies. This study found that the TRP-2 antigen also was expressed at significant levels in glioma cells and that a strong immune re...Researchers now on road to isolating skin stem cells
... major step toward isolating adult stem cells from mouse skin, having developed a test that confirms the presence and number of stem cells in a given amount of tissue. Until now, such a technique has only existed for isolating adult stem cells found in blood. "This assay has opened up a whole new avenue of...Other highlights in the September 17 issue of JNCI
...se oligonucleotides to inhibit hMYCN expression in mouse models of neuroblastoma. Mice treated continuously with antisense oligonucleotides had a lower incidence of neuroblastomas and lower mean tumor mass than mice treated with control oligonucleotides. "Our results raise the possibility that hMYCN antise...UCLA scientists invent search-and-destroy method to flush HIV out of hiding places in body
... they were confronting a foreign particle. "In our mouse model, the two-step approach cleared out nearly 80 percent of the latently infected T-cells," said Zack. "No one has ever been able to achieve this before. We hope that the strategy we've proven effective in the lab will show similar success in peo...BMPs and bone loss: Get it through your noggin
...inhibited osteoblast differentiation. A transgenic mouse that overexpressed noggin in mature osteoblasts displayed dramatic osteoporosis, decreased trabecular and calvarial bone, diminished bone formation rates, and reduced osteoblast differentiation. These studies provide strong evidence that the balance...Sensory cells for hearing and balance are fast-developing, UVA researchers find
...lance takes place over a period of just one day in mouse embryos, according to a study by a research team a...at three essential elements for development in the mouse inner ear appear between day 16 and day 17 of gestation, roughly equivalent to the late second trime...Lotion made from tea could help fight skin cancer
... to develop, they say. In laboratory studies using mouse models of skin cancer in which the mice were exposed to ultraviolet light, the researchers demonstrated that topical exposure to green tea polyphenols decreased levels of the enzyme, which in turn delays or blocks the skin's response to UV light. Sim...Existing anti-inflammatory drug could help children suffering from an inherited bone disease
...but occurs in children with growing bones. In the mouse study, researchers found that a particular Federal Drug Administration-approved drug, Indomethacin, keeps the body from wasting needed amounts of phosphate without causing the potentially life-threatening complications of conventional therapies. Indo...Stanford research shows targeted DNA vaccine may reverse autoimmune disease
...ren, MD, PhD, showed that this strategy works in a mouse model of M.S. called experimental autoimmune encep...rom EAE mice using the array, they found that each mouse had a unique pattern of reactivity. Based on their antibody profiles, mice whose immune systems were...Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
...ts removed the ovaries from mice, then studied the mouse T cells in culture. They confirmed that T cell activation was jump started by the immune regulatory protein interferon gamma (IFN-g), which in turn stimulated a protein called class II transactivator (CIITA). They found that increased expression of...Green teas cancer-fighting allure becomes more potent
...e chemicals shut down the AH receptor in cancerous mouse cells, and early results indicate the same is true in human cells as well. In the laboratory the AH-inhibiting effects of green tea become evident when EGCG and EGC reach levels typical of those found in a cup of green tea. But the scientists say t...JCI table of contents, 1 August 2003
... to decrease Abeta-related lesions in the brain in mouse models of AD. Unfortunately, the first clinical tr...ned the role of P2Y12 in platelet thrombosis. In a mouse model of arterial injury, the appearance of thrombi was delayed in mice lacking P2Y12. When thrombi ...Immune response to Alzheimer diseaserelated protein changes as we age
... to decrease Abeta-related lesions in the brain in mouse models of AD. Unfortunately, the first clinical trials for Abeta vaccination in humans were halted due to side-effects experienced by a small subset of subjects. However, these immunization strategies remain a viable concept in developing treatments ...$13 million grant puts new herpes-based AIDS vaccine on fast track
...virus was injected into mice, healthy cells in the mouse began making those proteins. The immune system, in turn recognizing the proteins as foreign began producing antibodies and killer T-cells to attack and destroy them. Should an HIV infection strike, the researchers hope that those antibodies and k...Emory University researchers find clue to Huntington's disease mechanism
...er growth signals. When the scientists examined a mouse model for Huntington's disease (transgenic mice th...tant proteins. But our research confirms that the mouse model works well for the hypothalamus and that HAP-1 loss of function is involved." In cell cultur...UCI resarchers create first living model to exhibit
... Calif. -- A newly engineered, genetically altered mouse will allow researchers for the first time to study...robiologists Frank LaFerla and Salvatore Oddo, the mouse is expected to provide a better "living laboratory" for understanding how these lesions grow, aiding...UCSF-led team discovers possible cancer 'susceptibility' gene
...t for only 5-10 percent of cancers. Evidence from mouse models and human epidemiologic studies suggests th...selves, these subtle variations are not harmful. A mouse or human that inherits a mildly more active form of a certain regulatory gene such as myc or ras w...