Patient with drug-resistant form of HIV identified
...n previously described, as has the transmission of multidrug resistant viruses. However, the unique feature of ...s report is the combination of these two features multidrug resistance and rapid clinical course to AIDS. Previous research suggests that the likelihood to pro...Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
...three of the four individuals had HIV viruses with multidrug resistance. The fourth sample was unable to be tested for resistance. Although standard tests that measure antibody response to the HIV virus have become increasingly sensitive, cases of HIV are occasionally missed because individuals can have negat...Simpler 'alphabet' guidelines for treating acute coronary syndrome reduce risk
...e of the complexity of monitoring and implementing multidrug and lifestyle treatments....American Thoracic Society Journal news tips for May 2004 (second issue)
Among a group of 205 patients who had multidrug resistant tuberculosis (TB) for an average of over...ect contrast to those from a 1973 to 1983 study of multidrug resistant TB patients treated at the same institution that showed a 56 percent long-term success rat......the bile transporters, bile salt export pumps, and multidrug resistancerelated protein 2 and repressed key genes involved in bile acid biosynthesis. FXR agonists may provide hepatoprotection in conditions of cholestasis both by increasing the capacity for bile excretion from the hepatoctye and decreasing bile ...Beta-blocker or calcium antagonist-based therapies equally effective in treating hypertension
...rol blood pressure, INVEST was intended to compare multidrug strategies rather than individual agents. The stu...ved in most hypertensive patients with CAD using a multidrug strategy that includes administration of angiotensin-converting enzyme (ACE) inhibitors to patients ...Jefferson scientist sees drug profiles and tailor-made therapies as ways to beat HIV resistance
...tching differentgeographic areas to gauge how much multidrug resistance is developing. Then wehave to find a way to agree on what the degree of clinically relevant resistanceis for each drug. "Clinically relevant drug resistance will differ for each drug, just asit is different for penicillin and vanc......idrug resistance markers such as p-glycoprotein or multidrug resistanceprotein. Among the topoisomerase I inhibitors tested to date, BNP1350 exhibitedmore in vitro potency against a variety of human tumor cell lines," said YoucefM. Rustum, Ph.D., Senior Vice President for Scientific Affairs at Roswell ParkCan...Successful Cancer Therapy May Doom Later Treatments To Failure
... mutants to gain a foothold. "You can't talk about multidrug resistance if you can't get the drugs into the tumor," says Jain. He believes there is another explanation for such disappointing results: chemotherapeutic agents may, by shrinking tumors, be shrinking blood vessel pores -- in effect, closing the doo......o successful cancer treatment is the developmentof multidrug resistance by tumors -- that is, tumors become bet...ed chemicals. The anti-drugpump is a major tool in multidrug resistance. The researchers have found a novel way to suppress production of the pump longenough fo...