Drug's Effect On Chromosomes May Explain Second Cancers
...formationthat unmasks oncogenes or other secondary mutations that cause the cellsto become cancerous,” he said. “This is still theoretical -- a guilt-by-association phenomenon.We need more data on what’s actually happening in cells and on whatthe downstream consequences are of telomere-specific...Cyclosporin Appears Effective In Treating Heart Disease
...isease, including HCM, are associated with genetic mutations that causethickening of the heart muscle wall. This thickening is known as cardiachypertrophy. In a previous study, published in April in the journal Cell, Dr. Molkentin andhis colleagues showed that the enzyme calcineurin can initiate cardiachypert...UCSF AIDS Expert Warns Against Early Treatment For HIV Infection
...Levy include: If virus replication takes place, mutations might develop that could lead to adrug-resistant strain of virus. -- He notes that mutations occurring at a steadyrate during HIV replication are random and would not select for virusesresistan...UNC Researchers Find Drug-Resistant HIV In Semen
...rus in their blood and genital tract thatcontained mutations known to decrease the susceptibility of that particularvirus strain to the available drugs," Eron explains. Moreover, when men with drug-resistant HIV in blood and semen werefollowed over time, "they continued to acquire higher levels of resi...Study Finds Less Intensive Treatments May Not Maintain HIV Suppression
...viral loadrebound. The presence of AZT-resistance mutations in HIV RNA was stronglypredictive of viral load rebound in individuals in the double-therapy group. "Interestingly, the magnitude of the increase in CD4+ T-cell count during thetriple-drug therapy phase of the study also correlated highly with subse......The structure reveals details that clarify how HIV mutations render the retrovirus resistant to antiviral drugs...isible in the newly solved structure clarifies how mutations alter binding to the DNA nucleotide or to the nucleotide analog antiviral drugs such as AZT. Harris...UCSF researchers discover new piece of puzzle in cancer development
...ichhave acquired some, but not all, of the genetic mutations that undermine a cell's regulatory control, did not progress further toward cancer. "The finding represents an important new insight into the complex process bywhich a cell becomes cancerous", said one of the senior authors of the study,Gerald R. Cun...Gene responsible for cerebral venous abnormalities found
... study, 16 had the same geneticmutation. Different mutations in the same gene in other non-Hispanic familieswer...e study as well. Cerebral cavernous mutations are lesions of large, abnormally shapedblood vessels in the brain. People with CCM often suffer fro...Genetic engineering changes the behavioral and hormonal response to stress
... Thestudy emphasizes the importance of single-gene mutations in responses to environmental strssors, which may contribute to the manifestation ofvarious neuropsychiatric disorders. Full reference: J Sallinen, A Haapalinna, E MacDonald, T Viitamaa, J Lhdesmki,E Rybnikova, M Pelto-Huikko, BK Kobilka, M Scheinin....UI findings indicate DNA methylation process may lead to oral cancer
...as of the body. Classical genetics has shown that mutations and deletions of these tumorsuppressor genes contribute to malignancy. However, another mechanism, DNAmethylation, can inactivate tumor gene expression as well, Domann said. Thismethylation phenomenon is the focus of Domann's lab investigations. Meth...Issues surrounding genetic medicine and the Jewish population to be explored at conference
...r, Cedars-SinaiMedical Center. "Some specific gene mutations are more common among people ofJewish ancestry, though no one population-Jewish or otherwise-has more mutationsor genetic diseases. They're just distributed differently among different ethnicgroups." The purpose of the conference is to provide inform...Abstemious mice offer hint at molecular target for treating alcoholism
...SF results may suggest, said the researchers, that mutations in the genefor the PKCe enzyme may influence the susceptibility of certain individuals tobecoming alcoholics. However, it's just as likely, they said, that they havesimply identified a mechanism for disrupting normally occurring molecularactivity at...Researchers uncover gene related to acute leukemia
...ssors, and from there itonly takes one or two more mutations to make a cancerous cell," Hiebert said. Hiebert's colleagues Bart Lutterbach, Ph.D., a Fellow of the Leukemia Society ofAmerica, research assistant Yue Hou, and graduate student Kristie L. Durstparticipated in the studies. The work was supported by......ion of the protein harbors many functional genetic mutations - and corresponding structural defects - responsible for hemophilia A. "A huge percentage of the total function of the factor VIII protein is tied up in this little domain at the end of the protein chain," Stoddard says, referring to the string of so...Scientists identify gene that detects DNA damage
...searchers at the UW Medical School have found that mutations in a gene they've been studying for several years... in cancer. Scientists previously had identified mutations in a single gene, called ATM, as the cause of A-T, but the UW team, led by associate professor of ge...MCG researchers find clues in process that enables working memory
... to working memory. She also is looking to see if mutations in the protein which was identified by researchers in the primate brain may help explain why schizophrenics typically lack normal working memory yet have normal dopamine D1 receptors. "Anything that regulates how the dopamine D1 receptor works coul...Cancer-preventive potential of white tea
...steps leading to cancer. White tea inhibited mutations more efficiently than green tea. This means it may have more potential to prevent cancer than green tea, says Gilberto Santana-Rios, Ph.D., a post-doctoral research associate with the institute, located in Corvallis, Ore. The researchers, now perf...New study finds multiple myeloma linked to radiation exposures of nuclear workers
...uring the child-bearing ages might lead to genetic mutations that could affect children and future generations." UNC-CH researchers identified 98 workers who died of multiple myeloma and 391 age-matched controls from a combined roster of 115,143 people hired before 1979 at the Hanford (Wash.), Los Alamos Nati...Protease inhibitor could help prevent alzheimer's
...cent of the U.S. population have inherited genetic mutations that may lead to the disease, according to the Alzheimer's Disease Education and Referral Center. Among reported cases of Alzheimer's, the remaining 90 percent are "sporadic," meaning they have no familial connection. All Alzheimer's cases, however...25-minute test distinguishes between different types of schizophrenia
...disease allowed researchers to find the APO-E gene mutations and to identify people at risk of developing the illness. Dr Tonmoy Sharma, the principal investigator of the study, hopes that identifying biological characteristics of early onset schizophrenia may do the same thing; ' By finding subtypes of the il...