Brain's nicotine receptors also target for anti-depressants
...mylamine, a noncompetitive antagonist (blocker) in nicotinic acetylcholine receptors (nAChRs). In a separate study using knockout mice that lack these receptors, they found that the function of the nicotine receptor in the brain was an essential component of the therapeutic action of antidepressants. Picciotto...Reduced risk of institutionalisation in patients with dementia
...also has a unique modulating effect on the brain's nicotinic receptors, which is believed to increase their effectiveness.7 Nicotinic receptors are thought to play a key role in attention, memory and learning. ...News tips from the Journal of Neuroscience
... no easy task. This week, Salas et al. report that nicotinic acetycholine receptors containing beta4 subunits a...akes it hard to quit. The authors suggest that the nicotinic receptors associated with negative reinforcement (withdrawal) may be different from those associated...Update on cholesterol guidelines: more-intensive treatment options for higher risk patients
...ses of statins with other drugs (bile acid resins, nicotinic acid, or ezetimibe) or with food products containing plant stanol/sterols. *Lower/Moderate Risk: The update did not revise recommendations for lower risk persons: those with moderate risk (2 or more risk factors plus an under 10 percent risk o...Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
...in, or vitamin B3, a mixture of the NAD precursors nicotinic acid and nicotinamide, which were discovered in 1938, prevents pellagra and can help control cholesterol. A class of anti-cancer drugs including tiazofurin and benzamide riboside is converted to toxic NAD analogs. And, more recently, proteins depende...Study supports new theory for nicotine's protective effect against neurodegenerative disorders
...hat nicotine helps protect the brain by binding to nicotinic acetylcholine receptors that sit on the end of nerve terminals. This action by nicotine, similar to turning up the volume of a radio signal, causes brain cells to increase the release of neurotransmitters depleted in diseases like Alzheimer's and Par...Scientists map maturation of the human brain
... other questions such as whether drugs that act at nicotinic acetycholine receptors could be used as treatments...The findings raise other questions such as whether nicotinic drugs could be used as treatments for ADHD, whether the effects we found are specific to people with...An anti-nicotine drug reduces the rewarding effects of alcohol
...desire to drink more. Mecamylamine is a central nicotinic receptor antagonist that is believed to reduce the... the receptor systems where alcohol may act is the nicotinic acetylcholine (NACh) receptor system, the same system where nicotine acts. By acting at these NACh ...Alcohol and nicotine: A deadly duo
... humans. The two studies collectively suggest that nicotinic mechanisms are involved in alcohol consumption. ...her study looks at the impact a drug used to block nicotinic effects called mecamylamine has on alcohols effects for humans. The results collectively suggest th...Lack of inhibition strengthens nicotine addiction
...hat nicotine produces pleasure by attaching to the nicotinic acetylcholine receptor found on certain nerve cell...rve cells have a slightly different version of the nicotinic acetylcholine receptor. Although they respond to the initial nicotine exposure, these receptors qui...New Alzheimer's treatment Reminyl™(galantamine) completes EU mutual recognition procedure
...3 (galantamine) also appears to act on the brain's nicotinic receptors. The "modulation" of these receptors could lead to release of more acetylcholine. *1,2,3 Two phase III studies published this month in Neurology showed that treatment with Reminyl™ (galantamine) significantly improves cognition, globa...First pivotal studies for new alzheimer's treatment published in Neurology
...hat galantamine also appears to act on the brain's nicotinic receptors. The "modulation" of these receptors could lead to release of more acetylcholine. 1,2,3 The clinical significance of this finding is not yet known, but is being investigated further by Janssen....New evidence suggests reconsidering causes and treatments for schizophrenia
...wo major types, utilizing muscarinic receptors and nicotinic receptors. More than 90 percent of the cholinergic receptors are muscarinic. Investigators reviewed a series of 15 studies they conducted over the previous decade and then performed two clinical trials. Through these, the authors find that the cho......ed because mecamylamine has plugged up some of the nicotinic receptor sites where the brain would naturally be ... Mecamylamine comes along and occupies some of the nicotinic acetylcholine receptor sites and prevents them from activating dopamine," Rose said. "So the net ef...