Targon And Duke Cancer Center Sign $3.75 Million Agreement To Produce Advanced Anti-Cancer Drugs
...bundant source of new ideas, but also an effective pathway to clinical application of those ideas. Duke's Com...f the drug has successfully disrupted the intended pathway in the cancer cell, while not interfering with similar pathways in healthy cells. Targon's support ...Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...n organs or bone marrow by disrupting thesignaling pathway that activates T cells. But both drugs can cause k...e that binds to calcineurin, a key molecule in the pathway thattransmits signals from the T cell receptor to the nucleus. The key differencebetween how the pep......inflammatory effectby interfering with a signaling pathway called NFkB, which is also activatedduring inflammatory cytokine production. PPARa inhibits the inflammatoryresponse by inhibiting the NFkB transcription pathway. This anti-inflammatory action of the fibrates has been confirmed in humans. Theresearch...Study Captures Images Of Memories Being Formed Within The Human Brain
...on is the left parahippocampal gyrus, a main input pathway to thehippocampus, a part of the brain that has long been recognized as crucial for storing and retrieving memories. The authors note that, while this areapreviously had been implicated in processing unfamiliar experiences, this studysuggests the par...Magnetic Hearing Aid Could Open New "Window" For Hearing Impaired
... intact and establishinga second independent input pathway to the inner ear opens the possibility forusing the normal acoustic pathway and round window electromagnet simultaneouslyto establish constructive and destructive sound pattern...... a non-classical,estrogen-mediated gene regulation pathway that plays a fundamental role inregulating bone loss in women following menopause. In May of 1998, Signal wasawarded a $750,000 Phase II SBIR grant from the National Institute of Diabetesand Digestive and Kidney Diseases to advance the Company's estr...Antabuse May Inhibit Fatal Reaction To Anesthetic
...rning off this enzyme we can prevent the molecular pathway leading tohalothane toxification, and by extrapolation, possibly prevent halothanehepatitis," he said. Kharasch has identified the role of p450 2E1 in the metabolism ofseveral other volatile anesthetics. The major component in Tylenol, for...Radically New Type Of Surgery Tested On First Patient
... brain surgery because it allows us to use acurved pathway to reach a target. Therefore we can go around sens...theter to a predetermined part of thebrain along a pathway planned by the surgeon. Matthew A. Howard III, M.D., associate professor of neurosurgery at theUniv...Scientists Link Body Weight Regulation And Immune System Control
...arsh, "because it suggests an additional molecular pathway thatcould affect immune function." Although the circulating form of the mahogany protein has not yet been found inmice, the implications are that the system is the same in mice and humans. "Ifthat turns out to be the case, a new window to the intric...Heart Drug Finds New Use In Patients With Wolff-Parkinson-White Syndrome
...rical impulses to travel down the shorteraccessory pathway and cause the heart to beat even faster, rather th...ct and pump blood at a steady pace. The accessory pathway foundin WPW patients allows electrical impulses to return back to atria rapidly andacts as a "short ...New Findings On Dopamine Receptor Biology: Implications For Mental Illness
... hasdemonstrated that D-4 activity uses the folate pathway as a source ofsingle-carbon methyl groups essential to affecting changes in nerve cellmembranes. When this process is defective, it might contribute to schizophreniaor other psychiatric disorders. Researchers from Northeastern University's Department......inhibiting differentparts of the hormone-producing pathway than MPA does. That may mean thatadditive therapy would be effective - several drugs working on differentpathways, each at lower doses than if it were used alone." In addition, Auchus said, now that they have shown that inhibiting this oneenzyme can...Scientists can now see sense of smell
...d non-invasive, we think it offers anextraordinary pathway to studying learning." Such learning experiments could involve imaging changes in animals'response to odorants as they are trained to associate an odorant with a reward,said Katz. Also, he said, by studying genetically altered mice with alter...Pain, itself, elicits pain relief, and does so through 'reward' pathway
...-lasting relief is produced by the brain's"reward" pathway -- the neural circuitry activated by drugs of abus...s to act in particular ways," said Gear.The reward pathway is a neural network in the middle of the brain that promptsgood feelings in response to certain beha...Study reveals how brain controls eating in normal rats
...ral fellow Elias and her colleagues identified the pathway between the two parts of the hypothalamus that app...ked leptin to eating. The new study tells how that pathway may work. Using two genetic markers of leptin action and nerve cell activity, the researchers have...UI researchers discover that aggressive cancer cells may make their own blood vessels
...chers' discoveries call attention to analternative pathway that is responsible for aggressive tumor growth and spread,the findings potentially could change the way cancers are regarded, diagnosedand treated. The UI investigation was conducted by Andrew J. Maniotis, Ph.D., assistantresearch scientist in anato...UI study suggests variable effects of fetal alcohol syndrome on brain
...tent corpus callosum. Thecallosum is a major brain pathway that coordinates input from one side of thebrain to the other to help provide unified sense perception. However, a studyled by a University of Iowa Health Care researcher suggests that moderate(versus severe) alcohol overexposure can cause the corpus...OHSU researchers test medication that targets fever without side effects
...is the first drug that can specifically target the pathway causingfever without a noticeable effect on the body's normal housekeeping functions." A total of 94 patients were involved in the trial. In addition to the testing inPortland, clinical research was conducted in Colorado, Illinois, Kansas, NewJerse......ncisco researchers have identified a new molecular pathway through which chemical signals alert the body to pain, and inhibiting the key protein in this pathway could bring relief in a broad spectrum of pain syndromes, they say. The finding, drawn from a study ......ts this first-ever,bird's-eye-view of the cellular pathway of the chemotherapeutic agent. The compound used was AN-152, a combination of the commonly prescribedchemotherapeutic agent doxorubicin, which is linked to an LH-RH (luteinizinghormone-release hormone) analog that targets only cells with LH-R...