Herbal dietary supplement alters metabolism of chemotherapy drug
...nal Cancer Institute . St. John's wort ( Hypericum perforatum L.) is widely used to treat mild to moderate forms of depression. Past studies have suggested that the compound increases levels of CYP3A4, an enzyme involved in drug metabolism. The enzyme inactivates the colorectal cancer chemotherapy drug irinote...... or picked from the wild commercially produced H. perforatum can fetch as much as $2,000 to $3,000 an acre. In the marketplace, however, not all St. John's wort products are the same. Previous studies have shown that the amount of hypericin in the plant - although usually labeled can vary from plant to pl......clinical pharmacology of St. John's Wort(Hypericum perforatum L.) Mol Psychiatry 1999;4:333-338. Researchers from the Swinburne University of Technology, Hawthorn, Australia,contributed to the study....