Clay reduces permeability of biomedical polymer
... "We decided to look at two methods for decreasing permeability a chemical method and a nanocomposites approach."...t and only achieved a factor of two improvement in permeability over the original polymer," Runt told attendees at the 222nd American Chemical Society annual meetin...Calcium-dependent potassium channels as target to increase drug delivery to brain tumors
...tassium channels of blood vessel cells to increase permeability of the blood-brain tumor barrier (BTB). As a resul...enabled them to increase blood-brain tumor barrier permeability and significantly increase the amount of a tracer going into tumors. Not only was the BTB effectivel...Other highlights in the September 4 issue of JNCI
...ed. The process was associated with an increase in permeability of the inner mitochondrial membrane and a decrease in oxygen consumption. These findings suggest that vanilloids may be useful for preventing or treating skin cancers. Contact: Laura Sussman, M. D. Anderson Cancer Center, 713-745-2457, lsussman@mdan...JCI Table of Contents, November 14, 2003
...tor (tPA): the regulation of vascular tone and the permeability of the blood-brain barrier (BBB). The authors demonstrate that an increase in perivascular tPA, as a consequence of cerebral ischemia, results in an opening of the BBB. Blockade of LRP, with anti-LRP antibodies or by other mechanisms, abolished the v...Microneedles: Report describes progress in new technology for painless drug delivery
...h holes in the outer layer of skin to increase its permeability to small molecules applied with patches. That work has broadened to include both solid and hollow microneedles in a broad range of shapes with feature sizes from one to 1,000 microns. Prausnitz and his research team have fabricated microneedle array...Mayo researchers invent targeted imaging probe to aid early Alzheimer's diagnosis
...lity to bind to amyloid plaques in mice, increased permeability at the blood-brain barrier, and contrast enhancement in MRI scans. Researchers also tested the probe in laboratory specimens of human Alzheimer's brains donated by families for biomedical research. While it behaved slightly differently in human brai...