Changing chemistry helps explain estrogen threat to the heart
... and Dr. Barman, along with Dr. David J. Fulton, a pharmacologist in the MCG Vascular Biology Center, found that every time they blocked nitric oxide production, estrogen became a vasoconstrictor. "Under normal conditions, such as a pre-menopausal woman, this enzyme, nitric oxide synthase, makes nitric oxide," say...Research with red tide toxin yields potential therapies for cystic fibrosis
...effects," said William Abraham, Ph.D., a pulmonary pharmacologist at Mount Sinai Medical Center and author of the study. "These compounds will serve as experimental models in the development of drug therapies for those who suffer from cystic fibrosis and other lung disorders characterized by excessive mucus secreti...Solvent, common drug plus hormones raise risk of reproductive failures and breast cancers
...trogen, progestin and even testosterone, said Duke pharmacologist Donald McDonnell, Ph.D. Such compounds are known as "endocrine disrupters" because they alter the normal course and behavior of hormones in the body. McDonnell is principal investigator of a study describing these results, to be published in the ...Nicotine metabolite shows promise for improving memory, protecting brain cells
...havior of schizophrenics, Dr. Jerry J. Buccafusco, pharmacologist and director of the MCG Alzheimer's Research Cente...ties," says Dr. Buccafusco, who is also a research pharmacologist at the Department of Veterans Affairs Medical Center in Augusta. "We hope this new appreciation for...UGA, MCG study impact of long-term use of schizophrenia drugs
...ember, says Dr. Alvin V. Terry Jr., pharmacist and pharmacologist at UGA and MCG. "Cognitive dysfunction has become a hot issue in schizophrenia research," says Dr. Terry, principal investigator on a $1.1 million National Institute of Mental Health grant to compare the cognitive effects of typical antipsychotics ...Preventing misuse of performance-enhancing substances a growing and difficult task
... of skill," Yesalis says. "The use of chemical and pharmacologist agents is cheating just like using a corked baseball bat. But unlike the bat, doping is shrouded in mystery. Athletes and their advisors are constantly seeking 'gray areas" surrounding the rules, and if something is not explicitly banned, then why n...Research confirms safety and efficacy of RemiFemin for menopausal symptoms
...al symptoms in women," said Steven Weisman, PhD, a pharmacologist and herbal expert. Study Design and Methods This controlled, randomized, double blind, multi-center trial was conducted at four gynecological clinics in Poland in accordance with the Good Clinical Practice Guideline. The study included 150 peri-...UT Southwestern Nobel laureate leads bold project changing way scientists conduct research
...it lots of data very quickly." Dr. Rochell Long, a pharmacologist with the NIGMS, said, "Advances in genomics, proteomics and informatics make the timing right for this bold experiment in how science is conducted. Al Gilman's vision is to transform the way cell signaling research is done, and he's dedicating his ca...Connecticut researchers receive national award
...e azithromycin. Animal studies conducted by Pfizer pharmacologist Arthur Girard confirmed the drugs effectiveness. When asked how he became interested in science, Bright said, "I had a real chemistry set as a kid, not like the ones today. And I had a lot of support from my parents." The Heroes of Chemistry program,...Drug blocks opioid side effects: Could improve palliative care
...invented in 1979 by the late University of Chicago pharmacologist Leon Goldberg, who wanted to help a dying friend who suffered from morphine-induced constipation. Goldberg started with naltrexone, an established drug that completely blocks the effects of morphine. He altered the drug slightly by attaching a methyl...Revived drug prevents malaria, skirts drug resistance
... says Theresa A.Shapiro, M.D., Ph.D., the clinical pharmacologist who led the Hopkins team. Further, pairing atovaquone with proguanil, an older malaria-fighting drug,"should greatly raise our chances of preventing malaria while avoiding the drugresistance that now plagues its treatment. Clobbering parasites at tw...Is drug abuse, not brutality, behind some deaths in custody?
... Together with Deborah Mash, a neurologist and pharmacologist at theUniversity of Miami School of Medicine, and Charles Wetli, medical examiner ofSuffolk County, New York, Karch has compared brain tissue taken at autopsy fromcocaine abusers who died of ED with tissue from people killed by cocaineoverdoses. They...Duke/Novalon researchers identify potential mechanism behind tamoxifen resistance in breast cancers
...are quite exciting," said Donald McDonnell, a Duke pharmacologist and leadauthor of the study report. "What this means is we can develop new drugs thattarget the estrogen receptor but don't form this new pocket when they attach toit. On the other hand, we can also develop a drug that will bind to this pocketand blo...Keep an eye on the weather if you take herbal antidepressants
...ch or while skiing. Ivor Roots, a clinical pharmacologist at Humboldt University in Berlin,agrees that people must exercise caution when using the herb. "One should notassume that herbal drugs are not without potential side effects," he says. "InGermany, it is recommended to avoid tanning beds while taking ...Far Few Drugs Are Tested On Children
...rk may be immature," says Robert Ward,a paediatric pharmacologist at the University of Utah in Salt Lake City. Market forces There are two main reasons why pharmaceuticals companies are reluctant to testtheir drugs on children. First, there is not much money to be made. Childrenconsume small quantities of drugs a...ACE-Inhibitors Score High In Reducing Heart Attack Deaths
...fter 30 days, says Maria Grazia Franzosi, Ph.D., a pharmacologist atthe Istituto di Ricerche Farmacologiche "Mario Negri" in Milan, Italy, who ledthe collaborative analysis. "For most individuals, ACE-inhibitor therapy may be started immediately --during the first few hours of a heart attack," she says. "Most of t...Scientists Produce New Anti-Malarial Compound
...ool of Arts and Sciences, andTheresa A. Shapiro, a pharmacologist and associate professor inthe School of Medicine. After figuring out artemisinin's Plasmodium-killing chemistry,the organic chemists were able to make the new compounds. Thecentral component of the mechanism is a ring of atoms, present inatemisinin a...Duke Study Suggests New Class Of Drugs Could Bypass Leptin Loop
...s might help in weight loss," said Collins, a Duke pharmacologist and co-author ofthe study. "These drugs could bypass the leptin system altogether and work at the fat cell site itself.The B3-adrenergic agonist would stimulate the receptor on fat cells and initiate the burning of storedfat." Based on results of t...