Tag: "phosphate" at medical news
Nature's Hardest Puzzle
...e a calcium hydroxy-apatiteformed from calcium and phosphate
ions, which are transported into thenanosphere matrix by ameloblast cells. "At first," Fincham explains, "the elongated apatite crystals will grow solelyon their end faces, becoming ever longer. With the nanospheres acting asspacers, these early cry...
Normal cellular enzyme becomes marker for Alzheimer's disease
...ein called a kinase that adds moleculartags called phosphate
groups to a host of cellular components. The researchershad a suspicion that CK-1 might add phosphate
tags to a protein called "tau,"which is present in AD plaques, tangles, and GVD bodies. Normally, t...
Abstemious mice offer hint at molecular target for treating alcoholism
... PKC enzymesact by "phosphorylating," or adding a phosphate
group, to receptors. In thiscase, the impact of phosphorylation appears to be dampening the brain's responseto alcohol. Other co-authors of the UCSF study were Kristin K. Mehmert, BS, Stephen P.Kelley, MS, Thomas McMahon, BS, and Ashley Haywood, BA,...
Penn researchers announce results of Phase I trial using combretastatin drug
..., 2000 in San Francisco. Combretastatin A4 phosphate
is a drug that is classified as a vascular targeting agent. It selectively targets and reduces or destroys blood vessels supplying malignant tumors while sparing the vasculature of normal tissues. Vascular targeting agents like combretastatin attack...
Purdue 'stealth compounds' attack cancer cells
...y adding another chemical component to the charged phosphate
of the nucleotide. Once the compound enters a cell, enzymes break it apart, releasing the nucleotides into the cell. Because the enzymes needed to break the compound apart are found only in cancer cells, the new method may allow researchers to deve...
Chemical found in computer can cause allergy, sickness
... the world's largest scientific society. Triphenyl phosphate
- a chemical compound widely used as a flame retar...ant compound. The presence and levels of triphenyl phosphate
in monitors varied with the place where they were manufactured, he explained....
UCSD and Japanese researchers identify new gene involved in development and function of central nervous system
...olecules. NUDEL is activated by the addition of a phosphate
group via an enzyme complex called CdK5/p35, which has been shown in previous studies to be essential for neural migration. NUDEL is closely linked to LIS1 on human chromosome 17 and mouse chromosome 11. In studies of mice, the researchers show t...
Material could lead to self-healing cavities
..., as a bioactive filler. ACP releases calcium and phosphate
ions, which "in the right proportions, can form the natural mineral [hydroxyapatite] that is found in teeth and bones." While researchers have known for several years about ACPs restorative powers, the NIST/ADA research group is unique in trying to...
Late-onset schizophrenia found to be distinct condition
...led hyper-phosphorylated. There are some groups of phosphate
molecules that attach to it and make it insoluble. When that happens, there is nothing to keep the microtubules going straight and carrying out their function." The researchers found this tauopathy not only in the majority of patients who had been di...
New drug linked to fewer deaths among kidney patients undergoing hemodialysis
... known as dialysis dementia." Other phosphorus or phosphate
binding agents were then used, including calcium c...cium levels, prompting a search for other types of phosphate
binders. Recently, a non-calcium phosphate
binder, Renagel, has come into use. Its maker, Genzyme ...
48-week results for the SOLO trial comparing GW433908/r QD to nelfinavir BID
...ith 908 The investigational PI 908 is the calcium phosphate
ester pro-drug of amprenavir. 908 is being studied in several dosing regimens: QD in combination with ritonavir in SOLO, BID in the NEAT trial, and BID and QD with ritonavir in the CONTEXT trial. 908 is being studied in regimens with or without foo...
Chemical turns stem cells into neurons say scientists at Scripps Research Institute
... whereby it modulates other enzymes by attaching a phosphate
group to them. The fact that modulating GSK-3beta leads the cells to become neurons reveals basic information on the complicated signaling cascade that turns a stem cell into a neuron. And the fact that TWS119 modulates the activity of GSK-3beta sug...
Consumers endorse researchers' enhancements to lower-quality beef
...ers also says that beef enhanced with a sodium and phosphate
solution pass the dinner-table quality test. The s...of enhancement -- 0.4 percent salt and 0.4 percent phosphate
-- used in the study even elevated often tough and less tasty standard-grade round roasts to a quali...
JCI table of contents, 1 August 2003
... condition is not caused by changes in calcium and phosphate
homeostasis, but by the decreased inhibitory activity of the remaining serum proteins on mineral formation. These findings demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide novel therapeutic targets for preven...
Existing anti-inflammatory drug could help children suffering from an inherited bone disease
...cin, keeps the body from wasting needed amounts of phosphate
without causing the potentially life-threatening c...s senior author. Children with rickets have vital phosphate
washed out of the body through urine. Too little phosphate
not only leads to rickets but also causes...
Vision-producing cells fail 'taste-test,' treat key light-detecting molecules identically
... The real off-switch turns out to be addition of a phosphate
group to the activated pigment, and subsequent binding by a protein called arrestin, says Yingbin Fu, Ph.D., a Howard Hughes postdoctoral fellow in neuroscience. Even though rods and cones each have their own phosphate-adding enzyme, the rod version ...
Fosrenol shows significant reduction in serum phosphate in Chinese end-stage kidney disease patients
...um carbonate) significantly reduced and maintained phosphate
levels in a study of Chinese end-stage renal disea...placebo (7.24 mg/dL, p < 0.001). This reduced phosphate
level was well within the phosphorus range of 3.5 to 5.5 mg/dL recommended in the new Kidney Disease...
Alzheimer's researchers begin unique study of tangles
...Alzheimer's patients, a stringy cluster of tau and phosphate
molecules form, leading to dysfunction that impairs the cell's ability to communicate with neighboring cells. This eventually leads to cell death, contributing to the confusion, disorientation and forgetfulness associated with Alzheimer's disease. ...
UCSD researchers describe cell activity leading to disruption of neuron migration
...tion protein called doublecortin. When Cdk5 adds a phosphate
molecule to doublecortin, the doublecortin is inac...ine that Cdk5 interacts with doublecortin to add a phosphate
molecule to a precise site on the protein. Next, the team inactivated Cdk5 in one group of neurons,...
Univ. of Pittsburgh to lead international trial for vocal cord paralysis and paresis
...cting voice production. CaHA is a form of calcium phosphate
present in bones and teeth, and has been used for bone replacement. CaHA acts as scaffolding for soft tissue ingrowth with the calcium/phosphate particles providing a strong, long-lasting foundation that allows local cellular infiltration. The result...