Beyond Viagra: other phosphodiesterase inhibitors are candidates for potential therapies
...uccess has raised interest in the growing study of phosphodiesterase (PDE) inhibitors, says Joseph Beavo, Ph.D., a professor of pharmacology at the University of Washington School of Medicine. Viagra works by inhibiting one specific type of enzyme called a cyclic GMP phosphodiesterase. "There is not just one, but m...Viagra helps men with heart failure
...chi. Sildenafil blocks the activity of the enzyme phosphodiesterase type 5 (PDE5), which is active in multiple tissues and cells. The effects of PDE5 inhibition include increased production of nitric oxide, which is associated with improved function of the heart and blood vessels. The cardiovascular effects of silde...CREST study finds cilostazol reduces restenosis by almost 40 percent
...(which prevents clot formation) plus cilostazol (a phosphodiesterase III inhibitor) or placebo after successful coronary stent implantation. Treatment with study medication (cilostazol or placebo) was continued for six months, when coronary angiography was performed to determine the presence of restenosis. In addition...Rolipram - a potential new treatment for Alzheimer disease
...that brief treatment of a mouse model of AD with a phosphodiesterase 4 inhibitor, rolipram, improves memory in both lon...suggests that drugs, such as rolipram, the inhibit phosphodiesterase have the potential to prevent the memory loss characteristic of Alzheimer disease....Sildenafil effectively treats enlarged hearts, mouse study shows
...earch because it blocks or stops an enzyme, called phosphodiesterase 5 (PDE5A), involved in the breakdown of a key molecule, cyclic GMP, which serves as a "natural brake" to stresses and overgrowth in the heart. "We thought we could more strongly apply the brake on hypertrophy in the heart if we used sildenafil to pr...