Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
...lls and escalates the immune response. The pivotal role of NFAT in T cell activation and immunosuppressionmakes it an active area of current research. Two groups of Harvard investigatorsreported the structure of NFAT bound to DNA in the March 5 Nature and the March6 Cell. Using x-ray crystallography ......d Co. sponsored research study,which UCSF played a pivotal role in coordinating. It was designed primarily toevaluate the effect of raloxifene on bone mineral density (BMD) and spinalfractures in women with osteoporosis. MORE investigators found that the osteoporosis prevention drug, raloxifene,significantl...Neurotransmission Machinery Visualized For The First Time
...rreconstructions that provide clues about how this pivotal protein complex mayaccomplish its mission. Within the neuron, vesicles fill up with neurotransmitters, such as dopamine orserotonin. They then travel out into the neuron's extensions (axons), where theydock at the membrane and await an electrochemic...Promising New Drug Uses Antibody Targeted Chemotherapy To Fight Leukemia
.... Promising data arenow emerging from the current pivotal Phase II trial in the U.S. that involvespatients following relapse after initial AML chemotherapy. A preliminaryanalysis of these data show that CMA-676 given alone produces a remission rate of approximately 40 percent - arate comparable to that of ......ents with early, active RA." The Phase III pivotal study evaluated 633 RA patients with early, activedisease who received ENBREL or methotrexate, using two primary endpoints: To study the ability of ENBREL to slow the progression of RA, thestudy utilized digitized x-ray data evaluation to monitor ...Breakthrough New Therapy Uses Antibody-Targeted Chemotherapy To Fight Leukemia
...cated. Promising results continue to emerge from a pivotal Phase II trial in the U.S.,which involves patients who experienced a relapse following initial AMLchemotherapy. CMA-676 given alone appears to produce remission among 36 percentof patients- a rate comparable to that of standard combination chemother...Abgenix Reports Positive Survival Data From A Phase II Trial Of ABX-CBL In Graft Versus Host Disease
...cutive officer of Abgenix. "We plan to initiate a pivotal Phase IIIclinical trial for ABX-CBL as soon as feasible after we have approval from theFDA to proceed." In March, at the International Bone Marrow Transplant Registry ("IBMTR")meeting, it was reported that, among patients in the three higher dose coh...Immunex Files Supplemental NDA for NOVANTRONE
...DA for priorityreview." The results of the pivotal NOVANTRONE Phase III data submitted to theFDA today showed that NOVANTRONE had a statistically significant impact onrelapse rate and disability progression in patients with secondary progressiveMS. These clinical data were corroborated by positive m...... final results from an international,multi-center, pivotal Phase II clinical trial of CAMPATHR for the treatm...be treatment related. Although notobserved in the pivotal trial, rare instances of vascular leak syndrome associated withcytokine release/infusion, marrow apl......egulatory approvalsubmitted today. The Phase III pivotal study evaluated 632 RA patients for one year. Allpatients in this study had RA for less than three years and had never beentreated with methotrexate. The study participants were randomized to receiveeither 25 mg or 10 mg of ENBREL, or methotrexate,...NOVANTRONE application for multiple sclerosis granted priority review by FDA
...eyevaluate these data." The results of the pivotal NOVANTRONE Phase III study showed thatNOVANTRONE had a statistically significant impact on reduction of relapse rateand delay in disability progression in patients with secondary progressive MS. Additional follow-up data presented at a recent interna......'s group found, if PKR isover-produced, it plays a pivotal role in the steps that lead to apoptosis orprogrammed cell death. If PKR is suppressed in a cell, that delays cell death. The scientists tested what would happen if they suppressed the action of PKR ina group of cells and exposed them to encephali...Estrogen-driven gene activates human pituitary tumors, Cedars-Sinai Medical Center researchers find
...variety of disorders by generating excess hormones pivotal to growth and reproduction, thyroid and adrenal function. This finding builds on the landmark 1997 discovery in Dr. Melmed's laboratory of the oncogene PTTG1 (pituitary tumor-transforming gene). Dr. Lin Pei, now a research endocrinologist at Cedars-S......versity, Austria and principal investigator of the pivotal NOVANTRONE Phase III study. There are 350,000 MS patients in the U.S. and approximately half will eventually develop an active progressive form of the disease which is characterized by a progression of disability that significantly impacts functionin...AIDS researchers get $10 million to continue studies
... the Adult AIDS Clinical Trials Group has played a pivotal role in defining the standard of care for adults infected with HIV. The group's trials have evolved from early studies with single-drug regimens to the current drug "cocktails" that make up high active antiretroviral therapy. Other recent studies ha......Once this is complete, a dose will be selected for pivotal efficacy trials, which will aim to evaluate the effect of TA-CD on reducing patient cocaine use. Cocaine is the second most commonly abused drug after alcohol and the average age of a cocaine user is 42. Most cocaine addicts are treated by physicians...Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia
... and then rejoin strands of DNA, a process that is pivotal for various cell functions. Leukemia can result when these normal DNA breaks are not properly reconnected, part of topo-II's mission. MLL is a promiscuous gene. Once broken, it can reconnect with any of more than 40 other genes in a translocati..."Radical" Discovery Advances Medicine and Plastics
...More recently, organic free radicals have played a pivotal role in basic research. They explain why some oxidation processes support life and others cause disease. They enhance our understanding of how the cardiovascular system functions, how DNA is synthesized in the body, and other scientific phenomena, in...First pivotal studies for new alzheimer's treatment published in Neurology
...two studies, conducted in the US, form part of the pivotal trials programme for galantamine which are now being reviewed by regulatory authorities worldwide. Reminyl was recently approved for the treatment of mild to moderate Alzheimer's disease in Sweden and Switzerland. "There are at least two victims in ...... hyperlipoproteinemia. A pooled analysis of three pivotal trials that were 24 weeks in duration showed median LDL-C reductions ranging from 35-38 percent in patients with dyslipidemia. LESCOL XL 80 mg produced a median reduction in TG of 19 percent in patients with dyslipidemia and 25 percent in patients w...