OHSU scientists test medication to treat involuntary weight loss
... stimulates appetite and reduces metabolic rate in preclinical trials. Neurocrine, which developed the test medication for this research, is now developing a related medication that will likely be tested in patients suffering from a common, disease-related form of malnutrition and involuntary weight loss called ...Neurobehavioral function during coma, stroke rehabilitation effective for elderly
...n the urethra. This animal model may be useful for preclinical testing of medications and other protocols aimed at rehabilitation or prevention of stress urinary incontinence. Education, social ties linked to quality of life in tracheoesophageal speakers, pg 115 This study investigates quality of life in adul...Penn study shows how next-generation diabetic drugs could work more selectively
...ide effects such as weight gain and edema. Indeed, preclinical research is already underway to design drugs called SPPARMs, selective PPAR modulators, which would specifically target genes in fat cells that can turn off the molecular pathways that may lead to these serious side effects. Working with mouse fat c...UGA researchers receive NIH contract to create a stem cell-based drug assay for SMA
...oal of the SMA Project is to identify and complete preclinical research and development of candidate therapeutics for treating SMA by late 2007. The UGA team hopes to have the first assay ready in one year. "All the talk surrounding stem cell research has focused on cell therapy," said Steven Stice, one of UGA'...Lab study: Protein delivered via genetically engineered virus slowed glioblasoma multiforme growth
...unt both the effectiveness of the treatment in the preclinical GBM animal model and also the lack of overt adverse side effects to the surrounding normal brain, we hope to start clinical trials using this combined immune and suicide gene therapy approach within the next three years," said Dr Castro. Amo...Novel drugs help solve Gleevec resistance
... fact that clinical responses matched very well to preclinical testing in animal models. A specific mutation that...-fold greater potency to inhibit BCR-ABL, based on preclinical tests that compared it to Gleevec, Talpaz says. Such experiments also have shown that it can treat 1...Molecular tailoring of chemotherapy with novel imaging techniques
...ith the bioluminescence imaging is in accelerating preclinical drug development. The gene silencing allows precise molecular characterization of targets that are relevant for therapeutic response while the imaging allows non-invasive assessment of drug activity towards implanted tumors. This approach saves time ...Mouse model gives insight to human hair loss
..."Our mouse model has proven to be very useful as a preclinical model to test new treatments for alopecia areata before being used in humans," states lead researcher, John P. Sundberg, D.V.M., Ph.D., of The Jackson Laboratory inBar Harbor, Maine. The study further provided the opportunity to use newly available ...St. Jude scientist to lead NCI Pediatric Preclinical Testing Program
...10-15 agents or combinations of agents annually in preclinical models of common childhood cancers. The PPTP is su... will develop procedures for generating sufficient preclinical information to allow pediatric oncology researchers to reliably prioritize new agents for study in c...South Florida's Small wins The Gerontological Society of America's 2004 Margret M. Baltes Award
...ch area of behavioral and cognitive aspects of the preclinical phase of Alzheimer's Disease. Beginning in 2000, he has published a programmatic set of empirical variables in which he shows the gradual and remarkably lengthy period of cognitive decline occurring prior to diagnosis of AD. In the nine years since r...NIAID launches program to improve medical tools against emerging infectious diseases
...tutions will evaluate newly discovered epitopes in preclinical or clinical studies, where feasible, for their capacity to elicit immune responses. For a list of NIAID category A, B and C biodefense pathogens, visit http://www2.niaid.nih.gov/Biodefense/bandc_priority.htm . NIAID is a component of the National In...M. D. Anderson receives SPORE grant for melanoma research
... these findings to the patient is this next step - preclinical and early research. There's a huge collection of ideas that need to be expedited. With the SPORE's translational emphasis, clinician-scientists and laboratory-scientists are able to truly partner together for the sake of getting these findings direct...Promising results for malaria vaccine trial
...ly long process. Decades are often needed from the preclinical testing of candidate vaccines to licensing and public availability. The current unprecedented public-private partnership for the development of malaria vaccines, with national and international agencies sharing the goals, should speed this process as...Department of Energy announces new agreement with USC, national labs and private company
... version of the implant, with 60 electrodes, is in preclinical trials. Despite having more electrodes, the implant itself is actually smaller than its predecessor, and requires a less invasive surgery to implant. The hope is to quickly move up to a significantly larger array in the next few years, and then-perha...DOE labs, universities and second sight partner to speed development of 'artificial retina'
... The next prototype, with 50-100 electrodes, is in preclinical trials. The project's "next generation" device would have 1,000 electrodes and hopefully would allow the user to see images. The Department of Energy-supported project is a collaboration of DOE national laboratories, universities and the private sec...Angiogenesis therapy successful for peripheral arterial disease
...ss of apoptosis. "The results of these preclinical studies demonstrate for the first time that stimulating innate VEGF gene expression leads to the creation of multiple forms of VEGF that appear to provide therapeutic angiogenesis," Annex said. ...Researchers develop better understanding of tamoxifen resistance in breast cancer patients
...Clarke and his Georgetown colleagues will next use preclinical studies to test the effects of adding interferon to tamoxifen treatment. "Used as a primary treatment, interferon can be extremely toxic, so we will need to carefully study doses and timing of drug delivery before this can be tested in patients," sa...Zengen reports positive phase I/II trial results of its peptide molecule for vaginal yeast infection
...ge of life-threatening diseases and disorders. In preclinical and clinical studies, CZEN 002 has been shown to directly kill pathological fungi, including Candida albicans, gram-negative and gram-positive bacteria, and to inhibit replication of HIV-1, the virus responsible for AIDS. About Vulvovaginal Candidi...Could autoantibodies predict future disease in healthy people?
...cate that autoimmune disease is preceded by a long preclinical phase in which individuals can be identified by the presence of autoantibodies. Such identification might allow immunological treatment whereby disease is prevented, as is already being studied in diabetes. Alternatively, even if disease cannot be pr...Cancer gene therapy news backgrounder: New ideas fuel next generation gene therapy research
... D. Anderson with the concept, vector development, preclinical trials and the first phase of testing," says Roth. "This agent has clinical benefit, and because of its novelty and lack of interest by major pharmaceutical companies, the only way to make it available to patients was to start a biotech company. But ...