UCI resarchers create first living model to exhibit
...uman genes that foster lesion growth: beta-amyloid precursor protein (APP), presenilin-1 and tau. APP is the source of the beta-amyloid protein that forms into brain plaques, while presenilin-1 is needed for this protein to form. Tau is the critical component of tangles. Using the triple-transgenic mouse, the...FDA-approved drugs shown to lower Alzheimer diseaserelated protein levels in mice
... of Abeta42 are generated from the Abeta42 protein precursor (APP) following cleavage with enzymes known as b- and gamma-secretases. Abeta40 is the most abundant, however Abeta42 is deposited earlier and more consistently than Abeta40 and is therefore more toxic. Of the NSAIDs tested, meclofenamic acid and flu...JCI table of contents, 1 August 2003
... of Abeta42 are generated from the Abeta42 protein precursor (APP) following cleavage with enzymes known as bet...is expansion involves the differentiation of early precursor fat cells, known as preadipocytes, into mature fat cells. Researchers at Rockefeller University in N...Vitamins C and E improve cardiovascular health in children with high cholesterol, study says
...lood flow is reduced. Endothelial dysfunction is a precursor to atherosclerosis, or the plaque build-up characteristic of cardiovascular disease. Endothelial function can be easily measured using ultrasound of a major artery in the arm, called the brachial artery. "These measurements are good indicators of blo......ndings explain how anxiety and depression may be a precursor that triggers this difficult-to-diagnose syndrome, according to a new report that will be published in the September/October 2003 issue of General Dentistry, the Academy of General Dentistry's (AGD) clinical, peer-reviewed journal. Oral habits of an...Pancreatic cancer linked to developmental cell signaling pathway
... of abnormal pancreatic cells that resembled human precursor lesions, suggesting that this pathway may have a role in the initiation of this cancer," said Thayer, an instructor in surgery at Harvard Medical School. "However, its true role in pancreatic cancer remains to be determined." The researchers also ex...Sphingosine kinase inhibitors may hold key to halting growth of some tumors
...ll growth. Cell membranes contain sphingomyelin, a precursor of two lipids: ceramide, which causes programmed cell death (apoptosis), and sphingosine 1-phosphate (S1P), which causes cell proliferation. The balance of ceramide and S1P determine whether cells multiply or die. A chain reaction with other enzymes...New clinical research study evaluates novel cell therapy
...to microcarriers. RPE cells produce levodopa, the precursor of dopamine. Dopamine is a neurotransmitter produced by nerve cells in the brain that progressively declines as the disease progresses. The RPE cells, which are normally found in the back of the eye, are cultured under standardized conditions and a...Childhood abuse related to alcoholism in Native Americans
... learned in tribal sobriety programs and was not a precursor to alcoholism," Koss says. Based on their findings, the researchers highlight the need to develop social programs for reservation-based families to lessen exposure to adult drinking and to establish intensive preventive education on childhood sexual ...Will stop-smoking patch help slow memory loss?
...by the American Academy of Neurology that may be a precursor of Alzheimer's disease. Often difficult to diagnose because of the mild nature of memory changes, MCI is characterized by symptoms such as increased forgetfulness, but is not accompanied by the disorientation, confusion and impaired judgment typical...Elementary signs of heart disease found in children
... or more risk factors of the metabolic syndrome, a precursor of cardiovascular disease, researchers reported today at the American Heart Association's Scientific Sessions 2003. "The risk was about 1.6 times higher for girls than boys," said the study's lead author Joanne S. Harrell, Ph.D., professor of nursing...New vaccine tested in animals may hold hope for Alzheimer's patients
...eered to express either mutated human amyloid beta precursor protein alone or in combination with mutated presenilin1. Mutations in these two genes are responsible for causing inherited forms of Alzheimer's disease in humans. Mouse brains from both groups showed decreased amyloid beta deposits and decreased gl...Regeneration of insulin-producing islets may lead to diabetes cure
... replacing diseased organs and tissues using adult precursor cells. "We have found that it is possible to rapidly regrow islets from adult precursor cells, something that many thought could not be done," says Denise Faustman, MD, PhD, director of th...USP's hospital medication error report supports key patient safety goals
...ach the patient. Participating hospitals use these precursor events to identify and strengthen safeguards that prevent errors from reaching patients, thus providing safer patient care. Currently, 20,000 records per month--an increase of 5,000 records per month from last year--are being entered into the MEDMARX...'Sunshine vitamin' shines in colon study
...rious colon polyps, or tumors, which are often the precursor to cancer. Another significant association with reduced risk was the use of non-steroidal anti-inflammatory drugs: Men who took a daily aspirin were about two-thirds as likely to have a tumor. Lieberman said further study is needed before recommendi...Study examines risk factors associated with colorectal cancer
...death due to colorectal cancer and that removal of precursor tumors may reduce the incidence of colorectal cancer. Identification of important risk factors for advanced colonic tumors could inform both risk stratification and development of risk reduction strategies. Few studies have evaluated risk factors for...Gene targeting prevents memory loss in Alzheimer's disease model
...to lack the enzyme but to also overproduce amyloid precursor protein, which BACE1 "clips" into fragments of beta-amyloid that eventually form the notorious plaques associated with Alzheimer's disease. The mice were healthy and had no serious neurological abnormalities, suggesting that BACE1 inhibition is a r...Carnegie Mellon uses AFM to discover effects of experimental drugs on Alzheimer's plaques
...made of beta amyloid (A), a peptide derived from a precursor protein found in cell membranes. Once cleaved from its parent protein, the A peptide readily aggregates into fibrils that are rich in insoluble stacked structures called beta sheets. These fibrils then congeal into tangled plaques. For the past few ...Newborn brain injuries stem from infections, not delivery
...ries to the white matter of a newborn's brain -- a precursor to cerebral palsy and other disorders -- to the baby's delivery, though a new Johns Hopkins study demonstrates that such injuries are more closely associated with neonatal infections. White matter, the tracts of nerve fibers that communicate messa......l stroke risk. "Metabolic syndrome looks like the precursor for a number of health problems," Najarian said. "Because the prevalence of the syndrome is so high, we need to start thinking about how to prevent the condition, particularly since it appears to be a factor in the continuum that leads to outright d...