Protein that promotes survival of stem cells might be key to poor leukemia prognosis
...he survival of these cells." Progenitor cells are precursors arising from HSCs; these cells produce daughter cells that become increasingly specialized and then produce specific types of blood cells, such as B lymphocytes--immune cells that produce antibodies. "Understanding the role of Mcl-1 in apoptosis and ...Leukemia drug breakthrough study in New England Journal of Medicine
...at the agent improved the growth of red blood cell precursors from MDS bone marrow. Celgene will submit the seminal findings of List's phase I trial - along with data from two recent confirmatory phase II clinical trials performed nationwide involving more than 350 patients with red blood cell transfusion-depen...Blocking molecules protects health of implants
...ble for the recruitment of foreign body giant cell precursors to the implant site. This study examined what would happen if the expression or function of CCL2 was eliminated both in mice genetically engineered without the molecule and in other mice where the function of CCL2 was blocked by means of a protein de...Antibiotic rifampicin shows promise for fighting Parkinson's disease in lab tests
...hemselves are toxic, and the other is that smaller precursors of the fibrils formed earlier in the process are toxic and cause the neurons to die," he said. Fink's group found that rifampicin stabilized alpha-synuclein in a soluble form, both as single molecules and in small, soluble clumps of the protei...Hong Kong think tank calls for pollution standards
...could lower the amount of fine particles and ozone precursors in the region by about 20 to 30 percent. And it would add only three-tenths of a percent to the cost of each good. A $100 DVD player, for instance, would only cost 30 cents more after emissions standards were put in place. Lead was one chemical part...New study lays to rest concerns about virtual colonoscopy as a screening tool
...59 flat lesions were adenomas, which are potential precursors to cancer, said Dr. Pickhardt. Virtual colonoscopy detected 83% of the flat adenomas. It detected 86% (156 of 181) non-flat adenomas, he added. "It is apparent that virtual colonoscopy is equally good for detecting both flat and non-flat types of ...Study showed vitamin D inadequacy highly prevalent among women treated for osteoporosis
.... 25(OH) D is produced by the body from vitamin D precursors and its level in the blood serum generally indicates the level of the body's vitamin D reserves. In this study, vitamin D inadequacy was defined as 25 (OH) D <30 ng/mL. Of the women studied, 52 percent had 25(OH)D <30 ng/mL and 36 percent ...New class of compounds promises to revive failing hearts
... class of NO-based compounds called nitroxyl (HNO) precursors that produce HNO. In early studies, these compounds seem to play a role in protecting the cardiovascular system from further damage during heart failure and in restoring function to organs affected by the debilitating condition. Scientists will annou...Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
...zymes. Niacin, or vitamin B3, a mixture of the NAD precursors nicotinic acid and nicotinamide, which were discovered in 1938, prevents pellagra and can help control cholesterol. A class of anti-cancer drugs including tiazofurin and benzamide riboside is converted to toxic NAD analogs. And, more recently, protei...Researchers define mechanism that enables stem cells to track migrating brain tumor cells
... The researchers also found that these astrocytic precursors expressed significant levels of a "chemokine recep...ariety of cell types, including neuronal and glial precursors in the developing brain. The only known chemokine that binds with CXCR4 is stromal-cell derived fact...Spinal disc repair start-up orthonics receives funding from Viscogliosi Brothers, LLC
... the surface properly, we can cause cells that are precursors to bone cells to become bone cells and start making bone, and we can cause cells that are precursors to cartilage cells to become cartilage cells and start making cartilage." The ability to control cel...Hormonal response to stress alters immune system function and alters mental and physical disease
...e stress-induced inflammatory immune responses are precursors to the chronic diseases of aging, says Dr. Malarkey. As the immune system modifies in response to hormones produced by stress as perceived by the brain, it produces soluble factors that affect the brain itself. Dr. Andrew H. Miller, Emory Universit...Fatty acid pathway, glucose combine to produce triacetic acid lactone
...oorganism to produce compounds that could serve as precursors to explosives or components in everyday devices such as liquid crystal displays or anti-cancer agents. In a presentation at the 227th National Meeting of the American Chemical Society, Illinois doctoral student Wenjuan Zha reported how the fatty acid...A new hypothesis about Alzheimer's disease
...h the disease. These fibrils and plaques and their precursors are implicated in neuronal loss. The inflammation process that creates these metabolites can be triggered by numerous stimuli, including infections that precede the onset of Alzheimer's disease by a significant amount of time -- perhaps years. "If...New eggs continue to develop in adult mice
... they proved to be germ cells (stem cells that are precursors to oocytes and are not associated with follicles). They also found signs in adult animals of meiosis, the specialized cell division that only occurs in the formation of sex cells, which, according to traditional thinking, should have stopped before ...UCSD's Dr. Leon Thal to receive Potamkin Prize, one of neurosciences' highest honors
... clinical trials using choline, lecithin and other precursors of acetylcholine. In 1981, he published his finding that choline chloride failed to improve cognition in Alzheimer's disease. This lack of initial success challenged him to explore alternative and novel ways to treat the cholinergic deficit of Alzh...Study moves in on why astronauts suffer bone loss
...and phosphorous slows, and production of bone-cell precursors called osteoprogenitor cells diminishes. All these changes result in weakened, brittle bones prone to fracture. While the bones of children may be able to eventually recover from such changes, adult bones have a harder time of it. Studies of Skylab a......developed progressive FNDI due to retention of AVP precursors in the hypothalamus, which causes cellular toxicity and progressive loss of AVP-producing neurons. In an accompanying commentary, John A. Philips III from Vanderbilt University discusses FNDI and other endocrine disorders that may be caused by simila...Nov/Dec 2003 Annals of Family Medicine tip sheet
...t human papillomavirus, one of the strongest known precursors of cervical cancer? The November/December issue a...n papillomavirus (HPV), one of the strongest known precursors of cervical cancer. According to a randomized trial of 103 women, a self-sampling technique using tw......se 1 (PC1) cleaves large inactive secreted protein precursors in order to release their bioactive fragments. In an earlier study, Stephen O'Rahilly and colleagues from the University of Cambridge described the only reported case of human PC1 deficiency. In the November 14 issue of the Journal of Clinical Invest...