Both inherited traits and tumor mutations affect response to treatment of leukemia
...treat ALL, such as etoposide and cyclophosphamide, preventing them from killing cancer cells. "The presence of the GSTM1 non-null polymorphism in a child means that the child has inherited the mechanism to more rapidly degrade some drugs," said Jose Claudio C. Rocha, M.D. Ph.D., a postdoctoral fellow on the pr...New laparoscopic hysterectomy offers quicker recovery time than traditional surgery
...vix in place also preserves pelvic floor function, preventing the usual incontinence most women experience after conventional hysterectomies. "For women who have a medical indication for a hysterectomy but who have been afraid of losing the support that the pelvic structure gives or fear losing sexual function,...Natural mentors help mold lives of teens, study says
...high level of monitoring -- an important factor in preventing substance abuse -- when they have only periodic contact with teens. Mentors may also inadvertently model negative behaviors such as smoking or drinking. The study concluded that the benefits of having a mentor generally were not enough to outweigh th...Columbia study finds hemophilia therapy dramatically improves outcomes for bleeding stroke
...," noted Dr. Mayer. "I was stunned to find that by preventing just 5 ml of additional blood about one teaspoon of bleeding in the brain, we were able to increase chances of patient survival by nearly 40%."The third highest cause of death in the United States, stroke is the leading source of permanent disabili...CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
...cide. This proved the important role CK2 played in preventing TRAIL-induced cell suicide. However, DRB did not have an effect on normal cells, which strongly suggests that CK2 blocks apoptosis only in cancer cells. Because DRB can also interfere with other cellular reactions, the researchers blocked CK2 using ...Hormone therapy increases risk of urinary incontinence
... using estrogen and progestin or estrogen alone in preventing coronary heart disease and hip fractures in postmenopausal women. Both trials ended prematurely because more harm than benefit was observed. The researchers found that menopausal hormone therapy increased the incidence of all types of UI at 1 year am...Investigational transplant drug effectively preserves kidneys while avoiding toxic side effects
...velop a medication as effective as cyclosporine in preventing initial rejection, while at the same time preserving the kidney and providing better patient outcomes." Dr. Larsen and Thomas Pearson, MD, DPhil, with colleagues at Bristol-Myers Squibb Pharmaceutical Research Institute, developed LEA29Y to selectiv...Gene signature can predict breast cancer spread
...werful tool to identify those patients at low risk preventing overtreatment in substantial numbers of patients. If confirmed in further studies, the recommendation of additional hormone or chemotherapy in patients with lymph-node negative breast cancer could be guided by this prognostic signature." In an accomp...Medication helps alcoholics control drinking
...f NTX for alcoholism gives a meaningful benefit in preventing a relapse," the review said, citing an 18 percent ...that the benefits of naltrexone lie not so much in preventing a patient from having one drink, but rather in breaking the cycle where one drink leads to many more...Researchers track program's success in curbing aggressive behavior
...iology and biostatistics whose research focuses on preventing mental health problems in youth. "Their rates of criminal activity, delinquency and antisocial behaviors were much lower compared to aggressive boys who did not receive the intervention The Good Behavior Game also increases the likelihood that these...Changing trends in herbal supplement use
...ns and minerals that may be lacking in the diet to preventing chronic disease, such as macular degeneration and cancer." "Approximately one quarter of adults in the United States use multivitamins, and this prevalence may increase following the recent recommendation that all adults take a multivitamin daily," t...Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
...ects," Dr. Hooper says. "It's incredibly useful in preventing the damage related to peroxynitrite as a toxic mol...ortantly, it stops the secondary injury cascade by preventing the neutrophils from getting into spinal cord tissues through the blood-brain barrier." Dr. Hooper a...Study shows protective equipment not very effective for rugby players
...us attempts to get a ball across a goal line while preventing the opposing team from doing likewise. And, of cou...d in rugby union has only limited effectiveness in preventing injuries. "We found that the risk of concussion was not reduced by the use of padded headgear or mou...Mount Sinai stroke prevention trial published in JAMA
...rd level of anticoagulation intensity, INR 2-3) in preventing all strokes and systemic embolic events. Results showed that patients treated with ximelagatran (n=1,960) had a 1.6 percent per year chance of having a stroke or systemic embolic event (51 events), compared to a 1.2 percent chance for 1,962 patients ...Simpler blood thinning medication effective for preventing blood clots and stroke
...d to be as effective as other common therapies for preventing stroke and recurrent blood clots, according to studies in the February 9 issue of JAMA. Ximelagatran is currently approved for use in some European countries but it has not been approved in the United States because of concerns about adverse effects...New stroke-prevention drug unlikely to be cost-effective except in patients at high risk of bleeding
... evidence that it was as effective as warfarin for preventing strokes. "Warfarin is extremely effective," says ...spirin, which is not nearly as good as warfarin at preventing blood clots and strokes. "Physicians would like to have a drug that's as effective as warfarin but d...Aetiology of congenital heart disease explained
... proved to restrict the extent of the damage, thus preventing pacemaker dependence or foetal death. "We believe that the antibody we've identified can be used as a marker for identifying the mothers who are at a high risk of developing this complication during pregnancy," says associate professor Marie Wahren-H...Varicella vaccine effective on chicken pox; Impact on herpes zoster unclear
...varicella. The vaccine may also have a key role in preventing zoster. "Even though it has been shown that varicella vaccine has had a major impact on the epidemiology of chickenpox in the U.S., we do not know what impact, if any, the widespread use of varicella vaccine will have on the epidemiology of herpes zo...World-first living donor islet cell transplant a success
...rtage of donor islet cells is the biggest obstacle preventing implementation for all patients who need it, Shapiro added. The mother of the diabetic daughter was in perfect health, while her daughter has been on the cadaver donors transplant list since September 2004. Before the surgery, the woman had been subj......le online. Although the vaccine was ineffective in preventing HIV infection, the trial represents a landmark in ...tudy. The vaccine was found not to be effective in preventing HIV infection; infection rates among those who were given the vaccine and those who were given place...