Partial Liquid Breathing Improves Lung Function, Chances of Survival in Sick Preemies
...have yet to secrete surfactant, the substance that prevents the air sacs from collapsing. Conventional therapy for this condition -- increasing the pressure and oxygen concentration inside the lung in an effort to force more oxygen into the blood stream -- can cause permanent lung damage and result in a chr...Common Drug-Capsule Coating Not As Inert As Previously Thought
...t the material forms an inert, steric barrier that prevents proteinsand other biological materials from sticking to foreign or man-made materials. Recent work at the University of Illinois, however, has revealed that thispolymer is not as inert as researchers thought. Chemical engineering professor Deborah L...Researchers Finding May Boost Effectiveness Of Anti-HIV Drugs
...ain,the researchers were interested in whether Pgp prevents protease inhibitors fromcrossing that barrier. They found that when they injected protease inhibitors into mice thathad been genetically engineered not to express Pgp, brain levels of the drugsclimbed to seven-to-40 times higher than in mice ...Snipping Inflammation In The Bud; New Agents May Provide Relief
...lls toshed the surface protein L-selectin and that prevents the cells from dockingwith each other. "It's a completely different strategy," said Kiessling. "It's like doing surgeryon a really small part of the cell's surface. We're removing a protein thatfacilitates an unwanted inflammatory response. One adva...Researchers Identify Candidate Immunosuppressant With Fewer Side Effects
... clinical application.The newly identified peptide prevents a single, specific step in the immunesystem's signaling pathway, so researchers anticipate that it will not causeserious side effects. Anjana Rao, professor of pathology, Patrick Hogan, investigator, andtheir colleagues at Harvard Medical Sch...Compound In Meat Prevents Diabetes, Study Suggests
...the onset of diabetes for a time or if it actually prevents it from ever occurring. We also want to really nail down the effects on the whole body," Houseknecht says. "We really have a lot to learn about this compound. For one thing, we have not optimized the dose. We picked a dose that is effective in fighti...Drug's Effect On Chromosomes May Explain Second Cancers
...-joinsthe cut ends to repair the break. Etoposide prevents the enzyme from completing its repair step. “Thedrug actually subverts the enzyme into a DNA damaging agent,” saidMuller. The researchers studied etoposide and five other topo II inhibitors onfragments of DNA that contained telomeres. Bas...Drug Prevents Hearing Loss Caused By Brain Tumor Therapy
...rain, helping protect braintissue.However, it also prevents large-molecule drugs such as carboplatin fromreaching a tumor inside the brain. Using a sugar solution to temporarily shrink the barrier cells, therebycreating spaces between them, Neuwelt and his colleagues literally "opened thegate" for d......data to address thequestion of whether finasteride prevents disease. The results are notreassuring," Ross says. In contrast to the NCI study (which is focusing on healthy men), the USC teamstudied 52 men with elevated blood levels of PSA (prostate specific antigen)whose biopsies showed no signs of prostate ca...Scientists Discover How Aspirin Reduces Inflammation
...mmatory process, aspirin inhibition of this kinase prevents NF-kBactivation and suppresses inflammation," Gaynor said. "This kinase is anexcellent target for the development of novel anti-inflammatory agents." In this paper Gaynor and colleagues clearly define a molecular stepwhere aspirin and salicyl...Maternal Tissue Typing Could Improve Selection Of Kidney Transplant Donors
...ey, this state of induced immune tolerance prevents rejection of the mismatched kidney. "Finding ways to induce immune tolerance to foreign tissue is the ‘Holy Grail’ of transplantation researchers," notes Steve Rose, Ph.D., chief of NIAID’s genetics and transp...... white blood cells, is an important mechanism that prevents the immunesystem from effectively fighting cancer. Phagocytes release free-radicals thatinduce T-cells and NK-cells, immune cells that are critical in the fight againstcancer and infectious diseases, into programmed cell death or apoptosis.Cytokines...Views Of Tamoxifen And Synthetic Estrogen In Action Provide Clues For Designing Better Drugs
...s. It delays the buildup of artery-cloggingplaque, prevents bone loss leading to osteoporosis, and may even postpone theonset of Alzheimer's disease. These benefits disappear at menopause, when womenstop making significant amounts of estrogen. Although taking replacementestrogen can restore these benefits, an...UNC Researchers Testing First In New Class Of AIDS Drugs
...HIV. The fusion inhibitor, known as T-20, prevents HIV from fusing with thecell surface membrane. Thus, T-20 attacks HIV in an entirely different way thanthe most potent HIV agents now in use. "HIV resistant to the currently available medications would not beexpected to be resistant to this d......bstance bindsvery tightly to the severed axons and prevents the rejoined axons from pullingapart once the animal recovers from anesthesia. The researchers have now successfully used this technique to rejoin thesevered halves of CNS and PNS axons from crayfish, earthworms, rats, rabbits,and guinea pigs......se the conventional deviceis stress shielding - it prevents force or stress to the bone. Without stress,they said, the bone atrophies, resulting in loosening of the implant. Another problem with the conventional device is that bone and metal are notcompatible. The bone does not integrate or grow into the me......tis, the telltale marker forchronic rejection that prevents air exchange in the lung's bronchioles, occurredin 4.7 percent of the bone marrow patients and 31 percent in those who did notreceive bone marrow. Similarly, the incidence of acute cellular rejection wasmuch lower in the study kidney/pancreas recipi......uced incidenceof chronic rejection, a process that prevents air to pass through the lung'sbronchioles. Chronic rejection occurred in 9 percent of the bone marrowpatients and in 42 percent of those who did not receive bone marrow. Inaddition, those lung patients receiving bone marrow had higher measures ofdo...UI Study Suggests Promising Treatment For Diabetic Pregnancies
...m from interacting with theislet cells and thereby prevents rejection. Unfortunately, the encapsulatedislet cells do not survive for long periods of time because the isolatingmaterial decreases oxygen supply to the cells. However, in the case of arelatively short-term use, such as pregnancy, Hunter thought th...New book on osteoporosis covers preventing and treating 'The Aging Disease' in consumer language
...ng inyouth, maintains bone mass in middle age, and prevents some bone loss withaging. Good sources are dairy products and calcium supplements. Vitamin D is essential for bone health. It promotes calcium intake andmaturation of bone cells. Good sources are sunlight and a daily multiplevitamin. The best di...